Novel polyphosphazene/poly(lactide-co-glycolide) blends: miscibility and degradation studies.

abstract：:In order to develop a more effective self-etching primer, with a longer lasting shelf life, we designed a self-etching primer comprised of methacrylamide, N-methacryloyl glycine, NMGly. In this study, the hydrolytic stability of the amide portion in the NMGly was examined. The difference in the hydrolytic stability be...

journal_title：Biomaterials

authors： Nishiyama N,Suzuki K,Yoshida H,Teshima H,Nemoto K

更新日期：2004-03-01 00:00:00

abstract：:Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-based gene therapies are hampered by our current inability to control w...

journal_title：Biomaterials

authors： Yin PT,Shah S,Pasquale NJ,Garbuzenko OB,Minko T,Lee KB

更新日期：2016-03-01 00:00:00

abstract：:Lung fibrosis is a poor prognostic factor for pulmonary adenocarcinoma, and the effect of a rigid microenvironment on cancer behavior is unclear. We cultured A549 cells on matrices of 0.2, 2, and 25 kPa to mimic the rigidities of normal lung parenchyma, progressive fibrotic change, and lung fibrosis, respectively. Lun...

journal_title：Biomaterials

authors： Chang CC,Hsieh TL,Tiong TY,Hsiao CH,Ji AT,Hsu WT,Lee OK,Ho JH

更新日期：2015-08-01 00:00:00

abstract：:Scaffolds derived from naturally occurring extracellular matrix (ECM) have found extensive use in the fields of tissue engineering and regenerative medicine. Many of these scaffolds are designed to degrade rapidly as they are replaced by new host tissue. Other scaffolds are chemically crosslinked to slow the rate of d...

journal_title：Biomaterials

authors： Gilbert TW,Stewart-Akers AM,Badylak SF

更新日期：2007-01-01 00:00:00

abstract：:The recreation of an in vitro microenvironment to understand and manipulate the proliferation and migration of invasive breast cancer cells may allow one to put a halt to their metastasis capacity. Invasive cancer cells have been linked to embryonic stem (ES) cells as they possess certain similar characteristics and g...

journal_title：Biomaterials

authors： Raof NA,Raja WK,Castracane J,Xie Y

更新日期：2011-06-01 00:00:00

abstract：:The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

journal_title：Biomaterials

authors： Wang X,Ma J,Feng Q,Cui F

更新日期：2002-12-01 00:00:00

abstract：:Carbon nanotube (CNT) possesses excellent properties as a drug carrier. To overcome the challenge of drug functionalization with CNT, we have developed a lipid-drug approach for efficient drug loading onto CNT, in which a long chain lipid molecule is conjugated to the drug molecule so that the lipid-drug can be loaded...

journal_title：Biomaterials

authors： Shao W,Paul A,Zhao B,Lee C,Rodes L,Prakash S

更新日期：2013-12-01 00:00:00

abstract：:Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, a...

journal_title：Biomaterials

authors： Kobayashi K,Ichihara Y,Sato N,Umeda N,Fields L,Fukumitsu M,Tago Y,Ito T,Kainuma S,Podaru M,Lewis-McDougall F,Yamahara K,Uppal R,Suzuki K

更新日期：2019-07-01 00:00:00

abstract：:There is extensive experimental and surgical experience with the use of bone tissue to fill defects in the skeleton, to bridge non-union sites, and to pack defects in bone created from cyst curettage. DP-bioactive glass with a chemical composition of Na2O 8.4%, SiO2 39.6%, P2O5 12% and CaO 40% has been reported as an ...

journal_title：Biomaterials

authors： Lin FH,Lin CC,Liu HC,Huang YY,Wang CY,Lu CM

更新日期：1994-10-01 00:00:00

abstract：:In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to reduce in-stent restenosis, the nonspecific inhibitory effects of anti-proliferative drugs, such as rapamycin, result in delayed re-endothelialization and fatal late stent t...

journal_title：Biomaterials

authors： Zhang H,Ren KF,Chang H,Wang JL,Ji J

更新日期：2017-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), as the fifth most common malignant cancer, develops and progresses mostly in a cirrhotic liver where stiff nodules are separated by fibrous bands. Scaffolds that can provide a 3D cirrhotic mechanical environment with complex native composition and biomimetic architecture are necessary f...

journal_title：Biomaterials

authors： Ma X,Yu C,Wang P,Xu W,Wan X,Lai CSE,Liu J,Koroleva-Maharajh A,Chen S

更新日期：2018-12-01 00:00:00

abstract：:The main challenge for neural progenitor cell (NPC)-mediated repair of spinal cord injury (SCI) is lack of favorable environment to direct its differentiation towards neurons rather than glial cells. The myelin associated inhibitors have been demonstrated to promote NPC differentiation into glial lineage. Herein, to i...

journal_title：Biomaterials

authors： Li X,Xiao Z,Han J,Chen L,Xiao H,Ma F,Hou X,Li X,Sun J,Ding W,Zhao Y,Chen B,Dai J

更新日期：2013-07-01 00:00:00

abstract：:At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release from AuNPs was de...

journal_title：Biomaterials

authors： Bhang SH,Han J,Jang HK,Noh MK,La WG,Yi M,Kim WS,Kwon YK,Yu T,Kim BS

更新日期：2015-07-01 00:00:00

abstract：:Canonical transient receptor potential channel 6 (TRPC6) can play an important role in governing how cells perceive the surrounding material environment and regulate Ca(2+) signaling. We have designed a TRPC6 reporter based on fluorescence resonance energy transfer (FRET) to visualize the TRPC6-mediated calcium entry ...

journal_title：Biomaterials

authors： Lei L,Lu S,Wang Y,Kim T,Mehta D,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:The hydrophilic nature of hydrogel matrices makes them disadvantageous to entrap poorly soluble therapeutic agents and greatly restricts their applications as drug-delivery systems. In this study, we demonstrated that sustained delivery of lipophilic drugs in hydrogel-based devices can be readily achieved by enhancing...

journal_title：Biomaterials

authors： Chen MC,Tsai HW,Liu CT,Peng SF,Lai WY,Chen SJ,Chang Y,Sung HW

更新日期：2009-04-01 00:00:00

abstract：:The advancement in gene therapy relies upon the discovery of safe and efficient delivery agents and methods. In this study, we report the design and synthesis of a cationic bolaamphiphile as a non-viral gene delivery agent. The bolaamphiphile is composed of 1,12-diaminododecane as the central hydrophobic unit linked t...

journal_title：Biomaterials

authors： Khan M,Ang CY,Wiradharma N,Yong LK,Liu S,Liu L,Gao S,Yang YY

更新日期：2012-06-01 00:00:00

abstract：:Type I collagen constitutes a major portion of the extracellular matrix (ECM) in arterial wall and it is the major substrate for cell growth and differentiation. The goal of this study was to evaluate the differentiation and proliferation of placenta-derived multipotent cells (PDMCs) on polymerized type I collagen fib...

journal_title：Biomaterials

authors： Chou MT,Chang SN,Ke C,Chang HI,Sung ML,Kuo HC,Chen CN

更新日期：2010-05-01 00:00:00

abstract：:Interest in the identification and isolation of circulating tumor cells (CTCs) has been growing since the introduction of CTCs as an alternative to the tumor tissue biopsy, which can potentially be important indices for prognosis and cancer treatment. However, the contamination of non-specific binding of normal hemato...

journal_title：Biomaterials

authors： Wu JC,Tseng PY,Tsai WS,Liao MY,Lu SH,Frank CW,Chen JS,Wu HC,Chang YC

更新日期：2013-07-01 00:00:00

abstract：:Palladium additions to a dispersed phase high-copper amalgam have been shown recently to suppress markedly the eta' (Cu6Sn5) concentration and decrease creep. A detailed study of the dental and 24 h creep for Pd containing high-copper amalgams and six commercial controls as a function of applied temperature and stress...

journal_title：Biomaterials

authors： Greener EH,Chung KH,Lin JH

更新日期：1988-05-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disability and death worldwide. An effective therapeutic approach is urgently needed. Stroke-induced angiogenesis and neurogenesis are essential mechanisms in the long-term repair. Extracellular matrix proteins are also involved in tissue self-repair. Recently, a PHSRN (Pro-His-...

journal_title：Biomaterials

authors： Wu CC,Wang LC,Su YT,Wei WY,Tsai KJ

更新日期：2018-12-01 00:00:00

abstract：:In order to improve the administration of drugs for all pathology of the oral cavity, we have developed an intraoral controlled release delivering system, permitting to reach high enough local concentrations for desirable therapeutic effect with minimal side effects. We have formulated tablets of 200 mg intended to be...

journal_title：Biomaterials

authors： Diarra M,Pourroy G,Muster D,Zingraff M,Boymond C

更新日期：1998-08-01 00:00:00

abstract：:Compression, tension and torsion tests were designed and completed successfully on a brushite and a precipitated hydroxyapatite cement in moist condition. Elastic and strength properties were measured for these three loading cases. For each cement, the full set of strength data was fitted to an isotropic Tsai-Wu crite...

journal_title：Biomaterials

authors： Charrière E,Terrazzoni S,Pittet C,Mordasini PH,Dutoit M,Lemaître J,Zysset PH

更新日期：2001-11-01 00:00:00

abstract：:Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...

journal_title：Biomaterials

authors： Crapo PM,Gilbert TW,Badylak SF

更新日期：2011-04-01 00:00:00

abstract：:Bone morphogenetic protein-2/absorbable collagen sponge (BMP-2/ACS) implants have been approved for clinical use to induce bone regeneration. We previously showed that exaggerated inflammation characterized by elevated level of inflammatory cytokines including TNF-α, IL-1β, and IL-6 has been shown to inhibit BMP-2/ACS...

journal_title：Biomaterials

authors： Huang RL,Chen G,Wang W,Herller T,Xie Y,Gu B,Li Q

更新日期：2015-10-01 00:00:00

abstract：:DNA that encodes tumor-specific antigens represents potential immunostimulatory agents. However, rapid enzymatic degradation and fragmentation of DNA during administration can result in limited vector expression and, consequently, poor efficacy. These challenges have necessitated the use of novel strategies for DNA de...

journal_title：Biomaterials

authors： Medina SH,Li S,Howard OM,Dunlap M,Trivett A,Schneider JP,Oppenheim JJ

更新日期：2015-01-01 00:00:00

abstract：:Nitric oxide (NO) is widely known as an effective vasodilator at low concentrations. Drug delivery systems combined with NO can dilate blood vessels surrounding tumor tissues, and the drug accumulation in tumors is accelerated by the enhanced permeability and retention effect, leading to an improvement in the anti-tum...

journal_title：Biomaterials

authors： Kang Y,Kim J,Park J,Lee YM,Saravanakumar G,Park KM,Choi W,Kim K,Lee E,Kim C,Kim WJ

更新日期：2019-10-01 00:00:00

abstract：:Semiconductor quantum dots and upconversion nanoparticles have been broadly used for live cell imaging due to their color tunability and photostability etc. However, these inorganic materials often contain heavy metals and potentially have metabolism problems. To overcome these issues, herein, we report a type of orga...

journal_title：Biomaterials

authors： Xu R,Huang L,Wei W,Chen X,Zhang X,Zhang X

更新日期：2016-07-01 00:00:00

abstract：:Previously we have formulated a new cationic emulsion, composed of 3beta [N-(N',N'-dimethylaminoethane) carbamoyl] cholesterol and dioleoylphosphatidyl ethanolamine, castor oil and Tween 80, and it efficiently delivered plasmid DNA into various cancer cells with low toxicity. Chitosan is a natural cationic polysacchar...

journal_title：Biomaterials

authors： Lee MK,Chun SK,Choi WJ,Kim JK,Choi SH,Kim A,Oungbho K,Park JS,Ahn WS,Kim CK

更新日期：2005-05-01 00:00:00

abstract：:Particle-based vaccine delivery systems are under exploration to enhance antigen-specific immunity against safe but poorly immunogenic polypeptide antigens. Chitosan is a promising biomaterial for antigen encapsulation and delivery due to its ability to form nano- and microparticles in mild aqueous conditions thus pre...

journal_title：Biomaterials

authors： Koppolu B,Zaharoff DA

更新日期：2013-03-01 00:00:00

abstract：:Membranes, clinically used to improve bone regeneration according to the osteopromotion principle, have primarily been made of expanded polytetrafluoroethylene (Gore-Tex Membrane). Recently, different types of biodegradable membranes have become available. This investigation explored the osteopromotive potential of 10...

journal_title：Biomaterials

authors： Zellin G,Gritli-Linde A,Linde A

更新日期：1995-05-01 00:00:00