A technique for preparing protein gradients on polymeric surfaces: effects on PC12 pheochromocytoma cells.

abstract：:Most urgent health problems are related to a blood vessel formation failure. The use of stem cells from different sources or species for both in vitro and in vivo engineering of endothelium does not necessarily imply their direct commitment towards a vascular phenotype. In the present study, we used human amniotic flu...

journal_title：Biomaterials

authors： Mirabella T,Cilli M,Carlone S,Cancedda R,Gentili C

更新日期：2011-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have gained increasing attention as a potential approach for the treatment of bone injuries due to their multi-lineage differentiation potential and also their ability to recognize and home to damaged tissue sites, secreting bioactive factors that can modulate the immune system and enhanc...

journal_title：Biomaterials

authors： Bunpetch V,Zhang ZY,Zhang X,Han S,Zongyou P,Wu H,Hong-Wei O

更新日期：2019-03-01 00:00:00

abstract：:Elasticity of cellular microenvironments strongly influences cell motility, phagocytosis, growth and differentiation. Currently, the relationship between the cell behaviour and matrix stiffness is being studied for cells seeded on planar substrates, however in three-dimensional (3D) microenvironments cells may experie...

journal_title：Biomaterials

authors： Kumachev A,Greener J,Tumarkin E,Eiser E,Zandstra PW,Kumacheva E

更新日期：2011-02-01 00:00:00

abstract：:In the traditional Chinese medicine, Gu-Sui-Bu [Drynaria fortunei (kunze) J. Sm] has been reported as a good enhancer for bone healing. In this experiment, we investigate the biochemical effects of this traditional Chinese medicine on the bone cells culture. Different concentrations of crude extract of Gu-Sui-Bu were ...

journal_title：Biomaterials

authors： Sun JS,Lin CY,Dong GC,Sheu SY,Lin FH,Chen LT,Wang YJ

更新日期：2002-08-01 00:00:00

abstract：:Although silicones possess many useful properties as biomaterials, their hydrophobicity can be problematic. To a degree, this issue can be addressed by surface modification with hydrophilic polymers such as poly(ethylene glycol), but the resulting structures are usually not conducive to cell growth. In the present wor...

journal_title：Biomaterials

authors： Alauzun JG,Young S,D'Souza R,Liu L,Brook MA,Sheardown HD

更新日期：2010-05-01 00:00:00

abstract：:RNA interference induced by double-stranded, small interfering RNA (siRNA) molecules has attracted great attention as a genetic therapeutic approach. Despite major advances in this field, new nanoparticle formulations are required for in vivo delivery of siRNA, particularly for tissue-specific delivery of siRNA reagen...

journal_title：Biomaterials

authors： Tagalakis AD,He L,Saraiva L,Gustafsson KT,Hart SL

更新日期：2011-09-01 00:00:00

abstract：:Although PEGylated TNF-related apoptosis-inducing ligand (PEG-TRAIL) has good tumor cell specificity and stability, its therapeutic potential is restricted by the development of tumor cell resistance. The purpose of this study was to develop an effective combination therapy with sustained biological activity based on ...

journal_title：Biomaterials

authors： Jiang HH,Kim TH,Lee S,Chen X,Youn YS,Lee KC

更新日期：2011-11-01 00:00:00

abstract：:Porous calcium phosphate ceramics consisting of hydroxyapatite (HA) and tricalcium phosphate (TCP) with different HA to TCP ratio were implanted intramuscularly in rabbits for six months in order to carry out a comparative study on osteogenic activity of the ceramics. Bone formation was detected only in HT73 (HA to TC...

journal_title：Biomaterials

authors： Kurashina K,Kurita H,Wu Q,Ohtsuka A,Kobayashi H

更新日期：2002-01-01 00:00:00

abstract：:We investigated the hypothesis that immobilizing TGF-β1 within fibrin hydrogels may act in synergy with cyclic mechanical stimulation to enhance the properties of vascular grafts. To this end, we engineered a fusion TGF-β1 protein that can covalently anchor to fibrin during polymerization upon the action of factor XII...

journal_title：Biomaterials

authors： Liang MS,Koobatian M,Lei P,Swartz DD,Andreadis ST

更新日期：2013-10-01 00:00:00

abstract：:The development of biocompatible photopolymerizing polymers for biomedical and tissue engineering applications has the potential to reduce the invasiveness and cost of biomaterial implants designed to repair or augment tissues. However, more information is needed about the cellular toxicity of the compounds and initia...

journal_title：Biomaterials

authors： Williams CG,Malik AN,Kim TK,Manson PN,Elisseeff JH

更新日期：2005-04-01 00:00:00

abstract：:The main challenge for neural progenitor cell (NPC)-mediated repair of spinal cord injury (SCI) is lack of favorable environment to direct its differentiation towards neurons rather than glial cells. The myelin associated inhibitors have been demonstrated to promote NPC differentiation into glial lineage. Herein, to i...

journal_title：Biomaterials

authors： Li X,Xiao Z,Han J,Chen L,Xiao H,Ma F,Hou X,Li X,Sun J,Ding W,Zhao Y,Chen B,Dai J

更新日期：2013-07-01 00:00:00

abstract：:Current tissue engineering strategies are focused on the restoration of pathologically altered tissue architecture by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable attention has been given to chitosan (CS)-based materials and their applications in the...

journal_title：Biomaterials

authors： Di Martino A,Sittinger M,Risbud MV

更新日期：2005-10-01 00:00:00

abstract：:In vitro protein adsorption, platelet adhesion and activation on new hydrogel surfaces, composed of poly(ethylene oxide) (PEO) and poly(tetramethylene oxide) (PTMO) or poly(dimethyl siloxane) (PDMS), were investigated. By varying PEO length (MW = 2000 or 3400), hydrophobic components (PTMO or PDMS) or polymer topology...

journal_title：Biomaterials

authors： Park JH,Bae YH

更新日期：2002-04-01 00:00:00

abstract：:Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine the feasibility of this technology for producing scaffolds for tissue engineering an aortic valve and the optimal concentration of collagen processed in this man...

journal_title：Biomaterials

authors： Taylor PM,Sachlos E,Dreger SA,Chester AH,Czernuszka JT,Yacoub MH

更新日期：2006-05-01 00:00:00

abstract：:A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phos...

journal_title：Biomaterials

authors： Ibim SE,Ambrosio AM,Kwon MS,El-Amin SF,Allcock HR,Laurencin CT

更新日期：1997-12-01 00:00:00

abstract：:Thermosensitive polymers poly(N-isopropylacrylamide) (PNIPAM), poly(N-vinylcaprolactam) (PVCL) and PVCL grafted with amphiphilic poly(ethylene oxide) (PEO) chains (PVCL-graft-C11EO42) were prepared and characterized and their putative cytotoxicity was evaluated. The cytotoxicity of these thermosensitive polymers and t...

journal_title：Biomaterials

authors： Vihola H,Laukkanen A,Valtola L,Tenhu H,Hirvonen J

更新日期：2005-06-01 00:00:00

abstract：:Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the important component in biofilm extracellular polymeric substances (EPS), extracellular DNA (eDNA) has been manifested to connect different EPS components and bacteria together, leading biofilms hard to eliminate. Herein a serie...

journal_title：Biomaterials

authors： Liu Z,Wang F,Ren J,Qu X

更新日期：2019-07-01 00:00:00

abstract：:Expansion of hematopoietic stem cells (HSCs) from cord blood is highly desired for treatment and transplantation of adult patients for hematologic diseases. For efficient proliferation of HSCs, CD34(+) cells from cord blood were co-cultured with microencapsulated murine stromal cells (HESS-5) or immortalized human mes...

journal_title：Biomaterials

authors： Fujimoto N,Fujita S,Tsuji T,Toguchida J,Ida K,Suginami H,Iwata H

更新日期：2007-11-01 00:00:00

abstract：:Topical therapy is the most favored form of treatment for whitening against hyper-pigmentation and sunburn because it lends itself to self-administration, patient compliance and an absence of systemic adverse effects. However, high-molecular-weight, hydrophilic chemicals are difficult to use as transdermal delivery dr...

journal_title：Biomaterials

authors： Ookubo N,Michiue H,Kitamatsu M,Kamamura M,Nishiki T,Ohmori I,Matsui H

更新日期：2014-05-01 00:00:00

abstract：:Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, po...

journal_title：Biomaterials

authors： Hernández-Rivera M,Zaibaq NG,Wilson LJ

更新日期：2016-09-01 00:00:00

abstract：:Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabrica...

journal_title：Biomaterials

authors： Xie L,Wang G,Zhou H,Zhang F,Guo Z,Liu C,Zhang X,Zhu L

更新日期：2016-10-01 00:00:00

abstract：:Nanoparticle-induced endothelial cell (EC) dysfunction, due to the induction of inflammation and/or the activation of the coagulation system, is associated with pulmonary and ischemic cardiovascular diseases. Although it is contigent on several mechanisms, involving formation of reactive oxygen species and inflammator...

journal_title：Biomaterials

authors： Bauer AT,Strozyk EA,Gorzelanny C,Westerhausen C,Desch A,Schneider MF,Schneider SW

更新日期：2011-11-01 00:00:00

abstract：:Photopolymerizable hydrogels, formed by UV-exposure of photosensitive polymers in the presence of photoinitiators, are widely used materials in tissue engineering research employed for cellular entrapment and patterning. During photopolymerization, the entrapped cells are directly exposed to polymer and photoinitiator...

journal_title：Biomaterials

authors： Fedorovich NE,Oudshoorn MH,van Geemen D,Hennink WE,Alblas J,Dhert WJ

更新日期：2009-01-01 00:00:00

abstract：:One of the key challenges for neural tissue engineering is to exploit supporting materials with robust functionalities not only to govern cell-specific behaviors, but also to form functional neural network. The unique electrical and mechanical properties of graphene imply it as a promising candidate for neural interfa...

journal_title：Biomaterials

authors： Tang M,Song Q,Li N,Jiang Z,Huang R,Cheng G

更新日期：2013-09-01 00:00:00

abstract：:The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6...

journal_title：Biomaterials

authors： Cenni E,Granchi D,Ciapetti G,Verri E,Cavedagna D,Gamberini S,Di Leo A,Pizzoferrato A

更新日期：1996-11-01 00:00:00

abstract：:In this work, an N-varied dissipative particle dynamics (DPD) simulation technique is applied to investigate detailed endocytosis kinetics for ligand-coated nanoparticles with different shapes, including sphere-, rod- and disk-shaped nanoparticles. Our results indicate that the rotation of nanoparticles, which is one ...

journal_title：Biomaterials

authors： Li Y,Yue T,Yang K,Zhang X

更新日期：2012-06-01 00:00:00

abstract：:The present work demonstrates that Cy5.5 conjugated Fe(3)O(4)/SiO(2) core/shell nanoparticles could allow us to control movement of human natural killer cells (NK-92MI) by an external magnetic field. Required concentration of the nanoparticles for the cell manipulation is as low as ~20 μg Fe/mL. However, the relative ...

journal_title：Biomaterials

authors： Jang ES,Shin JH,Ren G,Park MJ,Cheng K,Chen X,Wu JC,Sunwoo JB,Cheng Z

更新日期：2012-08-01 00:00:00

abstract：:Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly...

journal_title：Biomaterials

authors： Balas F,Kawashita M,Nakamura T,Kokubo T

更新日期：2006-03-01 00:00:00

abstract：:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light ...

journal_title：Biomaterials

authors： da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

更新日期：2002-07-01 00:00:00

abstract：:The histology and cytology of the tissue response to intra-articular insertion of particles of acrylic bone cement containing barium sulphate has been studied in the guinea pig knee joint. Following insertion of the acrylic, fibrinous debris admixed with particles became adherent to the synovial membrane. Cell prolife...

journal_title：Biomaterials

authors： Meachim G,Brooke G

更新日期：1984-03-01 00:00:00