Constitutive models for impacted morsellised cortico-cancellous bone.

abstract：:Given that vascular endothelial growth factor (VEGF) and placental growth factor (PIGF), over-expressed in breast cancer cells and M2-like tumor-associated macrophages (M2-TAMs) within tumor microenvironment (TME), work synergistically and independently in mediating tumor progression and immunosuppression, combinatori...

journal_title：Biomaterials

authors： Song Y,Tang C,Yin C

更新日期：2018-12-01 00:00:00

abstract：:Complement activation by polymeric gene and drug delivery systems has been overlooked in the past. As more reports appear in the literature concerning immunogenicity of polymers and their impact on gene expression patterns, it is important to address possible immune side effects of polymers, namely complement activati...

journal_title：Biomaterials

authors： Merkel OM,Urbanics R,Bedocs P,Rozsnyay Z,Rosivall L,Toth M,Kissel T,Szebeni J

更新日期：2011-07-01 00:00:00

abstract：:Hydrogels, microgels and nanogels have emerged as versatile and viable platforms for sustained protein release, targeted drug delivery, and tissue engineering due to excellent biocompatibility, a microporous structure with tunable porosity and pore size, and dimensions spanning from human organs, cells to viruses. In ...

journal_title：Biomaterials

authors： Jiang Y,Chen J,Deng C,Suuronen EJ,Zhong Z

更新日期：2014-06-01 00:00:00

abstract：:Implant-associated infections represent a significant health problem and financial burden on healthcare systems. Current strategies for the treatment or prevention of such infections are still inadequate and new strategies are needed in this era of antibiotic resistance. Melimine, a synthetic antimicrobial peptide wit...

journal_title：Biomaterials

authors： Chen R,Willcox MD,Ho KK,Smyth D,Kumar N

更新日期：2016-04-01 00:00:00

abstract：:The surface of polyetheretherketone (PEEK) was coated with a pure titanium (Ti) layer using an electron beam (e-beam) deposition method in order to enhance its biocompatibility and adhesion to bone tissue. The e-beam deposition method was a low-temperature coating process that formed a dense, uniform and well crystall...

journal_title：Biomaterials

authors： Han CM,Lee EJ,Kim HE,Koh YH,Kim KN,Ha Y,Kuh SU

更新日期：2010-05-01 00:00:00

abstract：:Water uptake characteristics of BisGMA-based composites incorporating untreated and surface-treated hydroxyapatite (HA) with a silane coupling agent have been investigated. The water absorption and desorption behaviour of these composites obeyed the classical diffusion theory. The diffusion coefficients of the composi...

journal_title：Biomaterials

authors： Santos C,Clarke RL,Braden M,Guitian F,Davy KW

更新日期：2002-04-01 00:00:00

abstract：:Dense, reconstituted collagen membranes, using an optimized cross-linking protocol, were implanted subcutaneously into rats. After implantation, only a mild inflammatory response in the surrounding tissues was observed. The morphology of the fibroblasts around the membranes was seen to go through characteristic stages...

journal_title：Biomaterials

authors： Boon ME,Ruijgrok JM,Vardaxis MJ

更新日期：1995-09-01 00:00:00

abstract：:Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...

journal_title：Biomaterials

authors： Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

更新日期：2011-12-01 00:00:00

abstract：:Porous scaffolds for skin tissue engineering were fabricated by freeze-drying the mixture of collagen and chitosan solutions. Glutaraldehyde (GA) was used to treat the scaffolds to improve their biostability. Confocal laser scanning microscopy observation confirmed the even distribution of these two constituent materi...

journal_title：Biomaterials

authors： Ma L,Gao C,Mao Z,Zhou J,Shen J,Hu X,Han C

更新日期：2003-11-01 00:00:00

abstract：:The recent introduction of microseparation of the components of ceramic-on-ceramic hip prostheses during hip simulations has produced clinically relevant wear rates, wear patterns and wear particles. This provided an opportunity to determine the response of primary human peripheral blood mononuclear cells to clinicall...

journal_title：Biomaterials

authors： Hatton A,Nevelos JE,Matthews JB,Fisher J,Ingham E

更新日期：2003-03-01 00:00:00

abstract：:Carbon nanotubes have shown great potential in various areas of biomedicine. Herein, we synthesize a series of amphiphilic polymers by anchoring polyethylene glycol (PEG) of different lengths at various densities on poly(maleic anhydride-alt-1-octadecene) (PMHC(18)). The blood circulation and biodistribution of those ...

journal_title：Biomaterials

authors： Liu X,Tao H,Yang K,Zhang S,Lee ST,Liu Z

更新日期：2011-01-01 00:00:00

abstract：:Effect of poly(epsilon-caprolactone) (PCL) content on the bioactivity and mechanical properties of PCL/silica hybrid was investigated. The PCL/silica hybrids with different PCL contents were prepared through co-condensation reaction with triethoxysilane end capped PCL and tetraethyl orthosilicate. The higher the PCL c...

journal_title：Biomaterials

authors： Rhee SH

更新日期：2004-03-01 00:00:00

abstract：:Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of topical ...

journal_title：Biomaterials

authors： Lin YH,Tsai SC,Lai CH,Lee CH,He ZS,Tseng GC

更新日期：2013-06-01 00:00:00

abstract：:Biomaterials interface with toll-like receptor (TLR) 9-mediated innate immunity in a wide range of medical applications, such as tissue implants and drug delivery systems. The stimulation of TLR9 can lead to two different signaling pathways, resulting in the generation of proinflammatory cytokines (i.e. IL-6) and/or t...

journal_title：Biomaterials

authors： Chen HC,Sun B,Tran KK,Shen H

更新日期：2011-02-01 00:00:00

abstract：:This study attempted to enhance the efficacy of peripheral nerve regeneration using our previously tested poly(L-lactic acid) (PLLA) conduits by incorporating them with allogeneic Schwann cells (SCs). The SCs were harvested, cultured to obtain confluent monolayers and two concentrations (1 x 10(4) and 1 x 10(6) SC/ml)...

journal_title：Biomaterials

authors： Evans GR,Brandt K,Katz S,Chauvin P,Otto L,Bogle M,Wang B,Meszlenyi RK,Lu L,Mikos AG,Patrick CW Jr

更新日期：2002-02-01 00:00:00

abstract：:Platinum nanoparticle-doped chitosan (CHIT) solution can be easily prepared by treating the CHIT solution with aqueous H2PtCl6 solution followed by chemical reduction of Pt(IV) with NaBH4. Multiwalled carbon nanotubes (MWCNT) are then dispersed in the nanoparticle-doped solution. The resulting Pt-CNT-CHIT material bri...

journal_title：Biomaterials

authors： Yang M,Yang Y,Yang H,Shen G,Yu R

更新日期：2006-01-01 00:00:00

abstract：:The development of multifunctional nanocarrier with each unit functioning at the correct time and location is a challenge for clinical applications. With this in mind, a type of intelligent mesoporous silica nanocarrier (PGFMSN) is proposed for matrix metalloprotease 2 (MMP 2)-triggered tumor targeting and release by ...

journal_title：Biomaterials

authors： Zou Z,He X,He D,Wang K,Qing Z,Yang X,Wen L,Xiong J,Li L,Cai L

更新日期：2015-07-01 00:00:00

abstract：:A lauric acid modified dextran-agmatine bioconjugate (Dex-L-Agm) was prepared by 1,1'-carbonyldiimidazole (CDI) activation and the nucleophilic reaction between tosyl of tosylated dextran and primary amine of agmatine. Dextran-agmatine bioconjugates (Dex-Agm) were capable of condensing DNA into nanocomplexes, and comb...

journal_title：Biomaterials

authors： Yang J,Liu Y,Wang H,Liu L,Wang W,Wang C,Wang Q,Liu W

更新日期：2012-01-01 00:00:00

abstract：:Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...

journal_title：Biomaterials

authors： Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

更新日期：2007-12-01 00:00:00

abstract：:Herein we describe a bio-inspired, affinity binding alginate-sulfate scaffold, designed for the presentation and sustained release of transforming growth factor beta 1 (TGF-β1), and examine its effects on the chondrogenesis of human mesenchymal stem cells (hMSCs). When attached to matrix via affinity interactions with...

journal_title：Biomaterials

authors： Re'em T,Kaminer-Israeli Y,Ruvinov E,Cohen S

更新日期：2012-01-01 00:00:00

abstract：:Multiple ophthalmic pathologies, such as retinal detachment and diabetic retinopathy, require the removal and replacement of the vitreous humor. Clinical tamponades such as silicone oil and fluorinated gases are utilized but limited due to complications and toxicity. Therefore, there is a need for biocompatible, stabl...

journal_title：Biomaterials

authors： Raia NR,Jia D,Ghezzi CE,Muthukumar M,Kaplan DL

更新日期：2020-03-01 00:00:00

abstract：:For a temporomandibular joint prosthesis, an estimation of the wear rate was needed, prior to patient application. Therefore, we determined the in vitro wear rate of the ball-socket articulation of this prosthesis, consisting of a metal head and an ultra-high molecular weight polyethylene (UHMWPE) cup. The basic testi...

journal_title：Biomaterials

authors： Van Loon JP,Verkerke GJ,de Bont LG,Liem RS

更新日期：1999-08-01 00:00:00

abstract：:Resurfacing of cartilage defects using cell-seeded, biomaterial grafts is a promising approach for articular cartilage repair and in this study we investigated the ability of human chondrocytes from osteoarthritic joints to generate cartilage tissue under standard conditions in cultured over 21 days on Hyalograft matr...

journal_title：Biomaterials

authors： Katopodi T,Tew SR,Clegg PD,Hardingham TE

更新日期：2009-02-01 00:00:00

abstract：:The thermally responsive cholesteryl end-capped poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and cholesteryl grafted poly[N-isopropylacrylamide-co-N-(hydroxymethyl) acrylamide] amphiphilic polymers were synthesized and utilized to encapsulate cyclosporin A (CyA) and indomethacin (IND) within core-shell nanopa...

journal_title：Biomaterials

authors： Chaw CS,Chooi KW,Liu XM,Tan CW,Wang L,Yang YY

更新日期：2004-08-01 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:The design of synthetic polymers may affect structural features of inflammatory cells, for example the expression of endogenous sugar receptor molecules like lectins in macrophages and foreign body giant multinucleate cells. This characteristic was studied histochemically by use of biotinylated (neo)glycoproteins. The...

journal_title：Biomaterials

authors： Smetana K Jr,Gabius HJ,Vacík J,Jelínková M,Lukás J

更新日期：1995-10-01 00:00:00

abstract：:pH-sensitive degradable chimaeric polymersomes were developed based on asymmetric poly(ethylene glycol)-b-poly(2,4,6-trimethoxybenzylidene-1,1,1-tris(hydroxymethyl)ethane methacrylate)-b-poly(acrylic acid) (PEG-PTTMA-PAA) triblock copolymers for active loading as well as triggered intracellular release of hydrophilic ...

journal_title：Biomaterials

authors： Du Y,Chen W,Zheng M,Meng F,Zhong Z

更新日期：2012-10-01 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns...

journal_title：Biomaterials

authors： Zhang K,Chooi WH,Liu S,Chin JS,Murray A,Nizetic D,Cheng D,Chew SY

更新日期：2020-10-01 00:00:00

abstract：:Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

journal_title：Biomaterials

authors： Kickhöfen B,Wokalek H,Scheel D,Ruh H

更新日期：1986-01-01 00:00:00

abstract：:One of the most common non-viral methods for the introduction of foreign deoxyribonucleic acid (DNA) into cultured cells is calcium phosphate co-precipitate transfection. This technique involves the encapsulation of DNA within a calcium phosphate co-precipitate, particulate addition to in vitro cell culture, endocytos...

journal_title：Biomaterials

authors： Kofron MD,Laurencin CT

更新日期：2004-06-01 00:00:00