Abstract:
:Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of topical antimicrobial agents was needed to complete the eradication of H. pylori in the infected fundal area. In the present study, we combined fucose-conjugated chitosan and genipin-cross-linking technologies in preparing multifunctional genipin-cross-linked fucose-chitosan/heparin nanoparticles to encapsulate amoxicillin of targeting and directly make contact with the region of microorganism on the gastric epithelium. The results show that the nanoparticles effectively reduced drug release at gastric acids and then released amoxicillin in an H. pylori survival situation to inhibit H. pylori growth and reduce disruption of the cell-cell junction protein in areas of H. pylori infection. Furthermore, with amoxicillin-loaded nanoparticles, a more complete H. pylori clearance effect was observed, and H. pylori-associated gastric inflammation in an infected animal model was effectively reduced.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Lin YH,Tsai SC,Lai CH,Lee CH,He ZS,Tseng GCdoi
10.1016/j.biomaterials.2013.02.028subject
Has Abstractpub_date
2013-06-01 00:00:00pages
4466-79issue
18eissn
0142-9612issn
1878-5905pii
S0142-9612(13)00197-Xjournal_volume
34pub_type
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