3-D physiomimetic extracellular matrix hydrogels provide a supportive microenvironment for rodent and human islet culture.

abstract：:Natural materials exhibit anisotropy with variations in soluble factors, cell distribution, and matrix properties. The ability to recreate the heterogeneity of the natural materials is a major challenge for investigating cell-material interactions and for developing biomimetic materials. Here we present a generic flui...

journal_title：Biomaterials

authors： Du Y,Hancock MJ,He J,Villa-Uribe JL,Wang B,Cropek DM,Khademhosseini A

更新日期：2010-03-01 00:00:00

abstract：:An oxygen-permeable membrane bioreactor utilizing human hepatocytes has been tested in this study. In the bioreactor, human hepatocytes were cultured between flat-sheet gas-permeable polymeric membranes, which ensure the diffusion of O(2) and CO(2) providing a support for cell anchorage and growth and permit the onlin...

journal_title：Biomaterials

authors： De Bartolo L,Salerno S,Morelli S,Giorno L,Rende M,Memoli B,Procino A,Andreucci VE,Bader A,Drioli E

更新日期：2006-09-01 00:00:00

abstract：:The management of trauma-associated nerve defects is difficult because of the absence of autologous donor motor or sensory nerves. Pre-clinical development and clinical experience has shown that damaged nerves can be surgically repaired using a tubular conduit interposed across the defect. Acceptable patient outcomes ...

journal_title：Biomaterials

authors： Sierpinski P,Garrett J,Ma J,Apel P,Klorig D,Smith T,Koman LA,Atala A,Van Dyke M

更新日期：2008-01-01 00:00:00

abstract：:Immunotherapy has shown promising treatment effects for a variety of cancers. However, the immune treatment efficiency for solid tumors is limited owing to insufficient infiltration of immune cells into solid tumors. The conversion of tumor-supportive macrophages to tumor-suppressive macrophages, inducing the function...

journal_title：Biomaterials

authors： Wang Y,Lin YX,Qiao SL,An HW,Ma Y,Qiao ZY,Rajapaksha RP,Wang H

更新日期：2017-01-01 00:00:00

abstract：:The development of topical microbicides is a valid approach to protect the genital mucosa from sexually transmitted infections that cannot be contained with effective vaccination, like HSV and HIV infections. A suitable target of microbicides is the interaction between viral proteins and cell surface heparan sulfate p...

journal_title：Biomaterials

authors： Donalisio M,Quaranta P,Chiuppesi F,Pistello M,Cagno V,Cavalli R,Volante M,Bugatti A,Rusnati M,Ranucci E,Ferruti P,Lembo D

更新日期：2016-04-01 00:00:00

abstract：:Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen ...

journal_title：Biomaterials

authors： Kumosa LS,Routh TL,Lin JT,Lucisano JY,Gough DA

更新日期：2014-09-01 00:00:00

abstract：:Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six ...

journal_title：Biomaterials

authors： Watson E,Smith BT,Smoak MM,Tatara AM,Shah SR,Pearce HA,Hogan KJ,Shum J,Melville JC,Hanna IA,Demian N,Wenke JC,Bennett GN,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2020-10-01 00:00:00

abstract：:To prevent bone metastasis, we developed polyethylene glycol (PEG)-conjugated aspartic acid (Asp)-modified liposomes (PEG-Asp-Lipo) as a bone-targeting carrier of paclitaxel (PTX) by using Asp-modified 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE-Asp). The affinity of Asp-modified liposomes to hydroxyapatite...

journal_title：Biomaterials

authors： Yamashita S,Katsumi H,Hibino N,Isobe Y,Yagi Y,Tanaka Y,Yamada S,Naito C,Yamamoto A

更新日期：2018-02-01 00:00:00

abstract：:Surface microroughness increases osteoblast differentiation and enhances responses of osteoblasts to 1,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3]. The observations that beta1 integrin expression is increased in osteoblasts grown on Ti substrates with rough microarchitecture, and that it is regulated by 1alpha,25(OH)2D3...

journal_title：Biomaterials

authors： Wang L,Zhao G,Olivares-Navarrete R,Bell BF,Wieland M,Cochran DL,Schwartz Z,Boyan BD

更新日期：2006-07-01 00:00:00

abstract：:Microbial polyhydroxyalkanoates (PHA) including poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) were found to induce chondrogenesis of mesenchymal stem cells (MSCs) and preserve chondrocytic phenotype as well as support chondrocytes-specific extracellular matrix (ECM) secretion. In this study, mouse MSCs cultur...

journal_title：Biomaterials

authors： Yan C,Wang Y,Shen XY,Yang G,Jian J,Wang HS,Chen GQ,Wu Q

更新日期：2011-09-01 00:00:00

abstract：:The clinical application of calcium phosphate cements (CPCs) composed of tetracalcium phosphate and dicalcium phosphate anhydrous has been limited because of its longer setting time, so that we developed the CPC in which the setting time was shortened to approximately 10 min. Aiming at clinical application, we evaluat...

journal_title：Biomaterials

authors： Hoshikawa A,Fukui N,Fukuda A,Sawamura T,Hattori M,Nakamura K,Oda H

更新日期：2003-12-01 00:00:00

abstract：:The purpose of this study was to compare the osseointegration of 4 different kinds of bioactive ceramic-coated screws with uncoated screws by biomechanical and histomorphometric analysis. Calcium pyrophosphate (CPP), apatite-wollastonite 1:3 glass ceramic (W3G), apatite-wollastonite 1:1 glass ceramic (WAG) and bioacti...

journal_title：Biomaterials

authors： Lee JH,Ryu HS,Lee DS,Hong KS,Chang BS,Lee CK

更新日期：2005-06-01 00:00:00

abstract：:Solid tissues in the body possess a range of stiffness and provide cells with an instructive microenvironment. Scaffolds in tissue engineering should be rationally designed to become an adhesion substrate friendly to cells. Schwann cells are the principal glial cell in the peripheral nervous system and used as support...

journal_title：Biomaterials

authors： Gu Y,Ji Y,Zhao Y,Liu Y,Ding F,Gu X,Yang Y

更新日期：2012-10-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) are the vital, life-long source of all blood cell types. They are found in stem cell niches, specific anatomic locations that offer all the factors and signals necessary for the maintenance of the stem cell potential of HSCs. Much attention has been paid to the biochemical composition o...

journal_title：Biomaterials

authors： Altrock E,Muth CA,Klein G,Spatz JP,Lee-Thedieck C

更新日期：2012-04-01 00:00:00

abstract：:A major cross-cutting problem for glioma therapy is the poor extravasation and penetration of the payload drug in target glioma parenchyma. Here, to overcome these obstacles, a tumor vessel recognizing and tumor penetrating system is developed by functionalizating the poly (ethyleneglycol)-poly (L-lactic-co-glycolic a...

journal_title：Biomaterials

authors： Kang T,Gao X,Hu Q,Jiang D,Feng X,Zhang X,Song Q,Yao L,Huang M,Jiang X,Pang Z,Chen H,Chen J

更新日期：2014-05-01 00:00:00

abstract：:The ability to precisely pattern embryonic stem (ES) cells in vitro into predefined arrays/geometries may allow for the recreation of a stem cell niche for better understanding of how cellular microenvironmental factors govern stem cell maintenance and differentiation. In this study, a new gelatin-based laser direct-w...

journal_title：Biomaterials

authors： Raof NA,Schiele NR,Xie Y,Chrisey DB,Corr DT

更新日期：2011-03-01 00:00:00

abstract：:Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mito...

journal_title：Biomaterials

authors： Yang J,Cao Q,Zhang H,Hao L,Zhou D,Gan Z,Li Z,Tong YX,Ji LN,Mao ZW

更新日期：2018-09-01 00:00:00

abstract：:Metal particles and ions from hip prostheses have the potential to induce the production of reactive oxygen species (ROS), making them prime suspects for disturbing the cellular balance of oxidants/antioxidants (redox state of the cell). To better understand the cellular effect of metal ions from metal-on-metal prosth...

journal_title：Biomaterials

authors： Petit A,Mwale F,Tkaczyk C,Antoniou J,Zukor DJ,Huk OL

更新日期：2005-07-01 00:00:00

abstract：:In vitro solubility tests of hydroxyapatite, tetracalcium phosphate or tricalcium phosphate particles were performed in lactate, citrate, Gomoris or Michaelis buffer with pH 6.2 or 7.2 and in aqua destillata. The results showed that in general the solubility decreased in the order tetracalcium phosphate greater than t...

journal_title：Biomaterials

authors： Klein CP,de Blieck-Hogervorst JM,Wolke JG,de Groot K

更新日期：1990-09-01 00:00:00

abstract：:We design a class of water-dispersible hybrid nanogels for intracellular delivery of hydrophobic curcumin. The core-shell structured hybrid nanogels were synthesized by coating the Ag/Au bimetallic nanoparticles (NPs) with a hydrophobic polystyrene (PS) gel layer as inner shell, and a subsequent thin hydrophilic nonli...

journal_title：Biomaterials

authors： Wu W,Shen J,Banerjee P,Zhou S

更新日期：2011-01-01 00:00:00

abstract：:Sintering reactions and fine structures of the biocomposites prepared from powder mixtures of titanium ( alpha -Ti), hydroxyapatite (HA) and bioactive glass (BG) (SiO2-CaO-P2O5-B2O3-MgO-TiO2-CaF2) were investigated by X-ray diffraction and transmission electron microscopy. The results showed that complex reactions amo...

journal_title：Biomaterials

authors： Ning CQ,Zhou Y

更新日期：2004-08-01 00:00:00

abstract：:We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 microm dependin...

journal_title：Biomaterials

authors： Ferreira L,Gil MH,Cabrita AM,Dordick JS

更新日期：2005-08-01 00:00:00

abstract：:The application of non-viral gene delivery vectors is often accompanied with the poor correlation between transfection efficiency and the safety profiles of vectors. Vectors with high transfection efficiencies often suffer from high toxicities, making it unlikely to improve their efficiencies by increasing the DNA dos...

journal_title：Biomaterials

authors： Zheng N,Yin L,Song Z,Ma L,Tang H,Gabrielson NP,Lu H,Cheng J

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer disease (AD) is a neurodegenerative disorder and the most common form of dementia. Histopathologically is characterized by the presence extracellular neuritic plaques and with a large number of neurons lost. In this paper, we design a new nanomaterial, graphene quantum dots (GQDs) conjugated neuroprotective ...

journal_title：Biomaterials

authors： Xiao S,Zhou D,Luan P,Gu B,Feng L,Fan S,Liao W,Fang W,Yang L,Tao E,Guo R,Liu J

更新日期：2016-11-01 00:00:00

abstract：:Different families of functionalized polymers with potential as biomaterials, or for biomaterial modification, have been investigated. In particular, degradation studies have been performed on poly(amidoamines), a family of polymers obtained by polyaddition of amines to bisacrylamides, and endowed with heparin-complex...

journal_title：Biomaterials

authors： Ferruti P,Ranucci E,Sartore L,Bignotti F,Marchisio MA,Bianciardi P,Veronese FM

更新日期：1994-12-01 00:00:00

abstract：:The creep strain rate and fracture of several dental amalgams has been shown to be markedly dependent on the type of loading applied. Cyclic loading typical of the in vivo situation increases creep rates and reduces times to fracture when analysis is based on a Mechanical Equation of State. The cyclic strain rate enha...

journal_title：Biomaterials

authors： Williams KR

更新日期：1983-10-01 00:00:00

abstract：:Theranostics, the integration of diagnostics and therapies, has become a new concept in the battles with various major diseases such as cancer. Here, we report a multifunctional nanoplatform, which is developed by covalently grafting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO...

journal_title：Biomaterials

authors： Wang Y,Wang H,Liu D,Song S,Wang X,Zhang H

更新日期：2013-10-01 00:00:00

abstract：:Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA nanotechnology and basic medical study. Here, we present a driving primer (DP)-triggered polymerization-mediated metastable assembly (PMA) stra...

journal_title：Biomaterials

authors： Xu J,Wu ZS,Wang Z,Le J,Zheng T,Jia L

更新日期：2017-03-01 00:00:00

abstract：:We have synthesized a series of coumarins (1-3) that can emit fluorescence in a turn-on manner through a Michael-type reaction with thiol-containing compounds. The only difference among the coumarins is the position of a carboxyl group on its benzene ring moiety near the double-bond conjugated coumarin. Their selectiv...

journal_title：Biomaterials

authors： Jung HS,Pradhan T,Han JH,Heo KJ,Lee JH,Kang C,Kim JS

更新日期：2012-11-01 00:00:00

abstract：:We recently showed that the highly organized architecture of the corneal stroma could be reproduced using scaffolds consisting of orthogonally aligned multilayers of collagen fibrils prepared using a high magnetic field. Here we show that such scaffolds permit the reconstruction in vitro of human hemi-corneas (stroma ...

journal_title：Biomaterials

authors： Builles N,Janin-Manificat H,Malbouyres M,Justin V,Rovère MR,Pellegrini G,Torbet J,Hulmes DJ,Burillon C,Damour O,Ruggiero F

更新日期：2010-11-01 00:00:00