On the microstructure of biocomposites sintered from Ti, HA and bioactive glass.

abstract：:This study was conducted to determine the interaction of individual corrosion products from biodegradable iron stents with cells from the adjacent tissue. The response of human umbilical venous smooth muscle cells (SMCs) to an excess of ferrous ions was investigated in a cell culture model at the phenotypic and at the...

journal_title：Biomaterials

authors： Mueller PP,May T,Perz A,Hauser H,Peuster M

更新日期：2006-04-01 00:00:00

abstract：:This study reports the effect of varying the thickness of a commercial zinc polycarboxylate dental cement on its adhesion in a metal-to-metal single lap joint. The thickness was controlled externally in a specially designed apparatus, rather than by the inclusion of isodimensional glass spheres, as has been done previ...

journal_title：Biomaterials

authors： Akinmade AO,Nicholson JW

更新日期：1995-01-01 00:00:00

abstract：:This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed ar...

journal_title：Biomaterials

authors： Heller J

更新日期：1980-01-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:Silica nanoparticles are widely used platform materials for the immobilization of proteins to realize applications in biomedicine and biotechnology. We here report on the use of a highly delicate protein for the systematic evaluation of routes for the surface modification of multifunctional silica nanoparticles. To in...

journal_title：Biomaterials

authors： Leidner A,Bauer J,Ebrahimi Khonachah M,Takamiya M,Strähle U,Dickmeis T,Rabe KS,Niemeyer CM

更新日期：2019-01-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:An in vitro perfusion system was used to study the platelet reactivity of the following vascular graft materials when tested with human blood: expanded polytetrafluoroethylene (ePTFE), crimped Dacron Bionit (DB) and preclotted Dacron Bionit (DB/PC). These materials were simultaneously compared to silicone rubber (SR) ...

journal_title：Biomaterials

authors： Kottke-Marchant K,Anderson JM,Rabinovitch A

更新日期：1986-11-01 00:00:00

abstract：:One of the major limitations of studying cancer-bone metastasis has been the lack of an appropriate ex-vivo model which can be used under defined conditions that simulates closely the in vivo live bone microenvironment in response to cancer-bone interactions. We have developed and utilized a three-dimensional (3D) can...

journal_title：Biomaterials

authors： Curtin P,Youm H,Salih E

更新日期：2012-02-01 00:00:00

abstract：:Colloidal nanoparticle drug delivery systems have attracted much interest for their ability to enable effective formulation and delivery of therapeutic agents. The selective delivery of these nanoparticles to the disease site can be enhanced by coating the surface of the nanoparticles with targeting moieties, such as ...

journal_title：Biomaterials

authors： Fay F,McLaughlin KM,Small DM,Fennell DA,Johnston PG,Longley DB,Scott CJ

更新日期：2011-11-01 00:00:00

abstract：:Among the many applications for carbon nanotubes (CNTs), their use in medicine has drawn special attention due to their potential for a variety of therapeutic and diagnostic applications. As progress toward clinical applications continues, monitoring CNTs in vivo will be essential to evaluate their biodistribution, po...

journal_title：Biomaterials

authors： Hernández-Rivera M,Zaibaq NG,Wilson LJ

更新日期：2016-09-01 00:00:00

abstract：:For chronic non-viral gene therapy, biodegradable carriers with low cytotoxicity are essential. To create a series of non-toxic and biodegradable gene carriers, hyperbranched polymers based on 2,2-bis-(methylol)propionic acid (bis-MPA); (Boltorn H) were modified by introducing tertiary amines. The terminal OH groups w...

journal_title：Biomaterials

authors： Reul R,Nguyen J,Kissel T

更新日期：2009-10-01 00:00:00

abstract：:Integrins represent the primary mechanism of cell-extracellular matrix interactions and control cell morphology, proliferation, and differentiation. We have previously shown that substrate-dependent modulation of adsorbed fibronectin (Fn) conformation alters alpha5beta1 integrin binding to Fn and directs C2C12 myoblas...

journal_title：Biomaterials

authors： Stephansson SN,Byers BA,García AJ

更新日期：2002-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibr...

journal_title：Biomaterials

authors： Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

更新日期：2016-11-01 00:00:00

abstract：:Amphiphilic block terpolymer conetworks composed of butyl methacrylate (BMA), 2,3 propandiol-1-methacrylate (GMMA) and ethandiol dimethacrylate (EDMA) were synthesized. Telechelic oligomers with the carboxylic acid end groups were made via ozonolysis of poly(BMA-co-butadiene) and then these were reacted with glycidyl ...

journal_title：Biomaterials

authors： Sun Y,Collett J,Fullwood NJ,Mac Neil S,Rimmer S

更新日期：2007-02-01 00:00:00

abstract：:Endocytosis is a fundamental biological process and is also the key mechanism for drug and non-viral gene delivery. The importance of topographical cues in modulating cell behaviors has become increasingly evident, but the influence of topography on endocytosis has however only been sparsely studied. We hypothesize th...

journal_title：Biomaterials

authors： Teo BK,Goh SH,Kustandi TS,Loh WW,Low HY,Yim EK

更新日期：2011-12-01 00:00:00

abstract：:Alginate/aminopropyl-silicate/alginate (Alg/AS/Alg) membrane was prepared on Ca-alginate gel beads by a sol-gel process. The membrane has identical to Si-O-Si identical to bonds as well as electrostatic bonds between amino groups of AS and carboxyl groups of alginate. Permeability and stability were investigated for t...

journal_title：Biomaterials

authors： Sakai S,Ono T,Ijima H,Kawakami K

更新日期：2002-11-01 00:00:00

abstract：:This paper completes the model of biodegradation for biodegradable polymers that was previously developed by Wang et al. (Wang Y, Pan J, Han X, Sinka, Ding L. A phenomenological model for the degradation of biodegradable polymers. Biomaterials 2008;29:3393-401). Crystallisation during biodegradation was not considered...

journal_title：Biomaterials

authors： Han X,Pan J

更新日期：2009-01-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:Amorphous carbon films have attracted much attention recently due to their good biocompatibility. Diamond-like carbon (DLC), one form of amorphous carbon that is widely used in many kinds of industries, has been proposed for use in blood contacting medical devices. However, the blood coagulation mechanism on DLC in a ...

journal_title：Biomaterials

authors： Yang P,Huang N,Leng YX,Chen JY,Fu RK,Kwok SC,Leng Y,Chu PK

更新日期：2003-08-01 00:00:00

abstract：:Polylactide (PLA) microspheres were coated with collagen for cell culture and injectable cell carriers. Utilizing a method of emulsion-solvent evaporation, PLA microspheres with diameter ranging from 180 to 280 microm were prepared, followed with aminolysis in hexanediamine/n-propanol solution to introduce free amino ...

journal_title：Biomaterials

authors： Hong Y,Gao C,Xie Y,Gong Y,Shen J

更新日期：2005-11-01 00:00:00

abstract：:The aim of this in vitro study was to evaluate the antimicrobial activity, the substantivity, and surface effects of the inclusion compound tetracycline: beta-cyclodextrin on bovine roots. The antimicrobial activity was assessed by dentine slabs which had been immersed in the inclusion complex in concentrations 8.0%, ...

journal_title：Biomaterials

authors： Pataro AL,Franco CF,Santos VR,Cortés ME,Sinisterra RD

更新日期：2003-03-01 00:00:00

abstract：:Macrophages are multifunctional immune cells with diverse physiological functions such as fighting against infection, influencing progression of pathologies, maintaining homeostasis, and regenerating tissues. Macrophages can be induced to adopt distinct polarized phenotypes, such as classically activated pro-inflammat...

journal_title：Biomaterials

authors： Kang H,Zhang K,Wong DSH,Han F,Li B,Bian L

更新日期：2018-09-01 00:00:00

abstract：:Decellularization techniques have been widely used as an alternative strategy for organ reconstruction. However, the compliance of tracheal or laryngeal tissues can be increased during the decellularization process, which might cause postoperative stenosis due to elimination of chondrocytes. The purpose of our study w...

journal_title：Biomaterials

authors： Ma R,Li M,Luo J,Yu H,Sun Y,Cheng S,Cui P

更新日期：2013-02-01 00:00:00

abstract：:The phenomenon of light-induced cell detachment is reported. Mouse calvaria-derived, pre-osteoblastic (MC3T3-E1) cells were cultured on a TiO(2) nanodot-coated quartz substrate. After 20 min of UV365 illumination, over 90% of the cells would detach from the surface. Moreover, intact cell sheets could be obtained in th...

journal_title：Biomaterials

authors： Hong Y,Yu M,Weng W,Cheng K,Wang H,Lin J

更新日期：2013-01-01 00:00:00

abstract：:The regeneration of large bone defects remains an unsolved clinical problem, which could benefit from recent findings on the biology of skeletal stem and progenitor cells. The elucidation of conditions to specifically control their dynamic and function will likely enable the development of novel treatment strategies. ...

journal_title：Biomaterials

authors： Papageorgiou P,Vallmajo-Martin Q,Kisielow M,Sancho-Puchades A,Kleiner E,Ehrbar M

更新日期：2019-10-01 00:00:00

abstract：:Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were developed for targeted drug delivery and positron emission tomography/magnetic resonance imaging (PET/MRI) dual-modality imaging of tumors with integrin α(v)β₃ expression. An anticancer drug was conjugated onto the PEGylated SPIO n...

journal_title：Biomaterials

authors： Yang X,Hong H,Grailer JJ,Rowland IJ,Javadi A,Hurley SA,Xiao Y,Yang Y,Zhang Y,Nickles RJ,Cai W,Steeber DA,Gong S

更新日期：2011-06-01 00:00:00

abstract：:Inherent neuronal and circulating progenitor cells play important roles in facilitating neuronal and functional recovery post stroke. However, this endogenous repair process is rather limited, primarily due to unfavorable conditions in the infarcted brain involving reactive oxygen species (ROS)-mediated oxidative stre...

journal_title：Biomaterials

authors： Petro M,Jaffer H,Yang J,Kabu S,Morris VB,Labhasetwar V

更新日期：2016-03-01 00:00:00

abstract：:The objective of this research was to investigate whether immobilized anti-inflammatory cytokines will signal changes in the inflammatory profile of cultured monocytes. A fusion protein of recombinant human IL-1 receptor antagonist and elastin-like peptide (IL-1ra-ELP) was expressed in Escherichia coli. THP-1 human mo...

journal_title：Biomaterials

authors： Kim DH,Smith JT,Chilkoti A,Reichert WM

更新日期：2007-08-01 00:00:00

abstract：:Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stab...

journal_title：Biomaterials

authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoit JP

更新日期：2003-10-01 00:00:00

abstract：:Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

journal_title：Biomaterials

authors： Kim MH,Kino-oka M

更新日期：2014-07-01 00:00:00