Abstract:
:An in vitro perfusion system was used to study the platelet reactivity of the following vascular graft materials when tested with human blood: expanded polytetrafluoroethylene (ePTFE), crimped Dacron Bionit (DB) and preclotted Dacron Bionit (DB/PC). These materials were simultaneously compared to silicone rubber (SR) using an identical perfusion circuit with the same donor's blood. All vascular graft materials tested in this in vitro perfusion system caused some degree of platelet activation as shown by a decrease in platelet count, an increase in platelet factor 3 activity, elevation of plasma levels of both platelet factor 4 and beta-thromboglobulin and decreased platelet aggregability. The observed platelet activation was striking for Dacron and especially preclotted Dacron, with ePTFE showing low levels of platelet activation. Platelet activation by Dacron was initially rapid and then levelled off, whereas the platelet activation with preclotted Dacron began more slowly, but reached much greater levels after three hours of in vitro perfusion.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Kottke-Marchant K,Anderson JM,Rabinovitch Adoi
10.1016/0142-9612(86)90032-3subject
Has Abstractpub_date
1986-11-01 00:00:00pages
441-8issue
6eissn
0142-9612issn
1878-5905pii
0142-9612(86)90032-3journal_volume
7pub_type
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