Abstract:
:Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or electromagnetic field. More recently, cryosurgery (also called cryotherapy and cryoablation), destruction of diseased tissues by first cooling/freezing and then warming back, has been used to treat various diseases including cancer in the clinic. Here we developed a cold-responsive nanoparticle for controlled drug release as a result of the irreversible disassembly of the nanoparticle when cooled to below ∼10 °C. Furthermore, this nanoparticle can be used to generate localized heating under near infrared (NIR) laser irradiation, which can facilitate the warming process after cooling/freezing during cryosurgery. Indeed, the combination of this cold-responsive nanoparticle with ice cooling and NIR laser irradiation can greatly augment cancer destruction both in vitro and in vivo with no evident systemic toxicity.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Wang H,Agarwal P,Liang Y,Xu J,Zhao G,Tkaczuk KHR,Lu X,He Xdoi
10.1016/j.biomaterials.2018.07.021subject
Has Abstractpub_date
2018-10-01 00:00:00pages
265-278eissn
0142-9612issn
1878-5905pii
S0142-9612(18)30499-Xjournal_volume
180pub_type
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