Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection.

Abstract:

:Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 °C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Korupalli C,Huang CC,Lin WC,Pan WY,Lin PY,Wan WL,Li MJ,Chang Y,Sung HW

doi

10.1016/j.biomaterials.2016.11.045

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

1-9

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(16)30669-X

journal_volume

116

pub_type

杂志文章
  • Switching between self-renewal and lineage commitment of human induced pluripotent stem cells via cell-substrate and cell-cell interactions on a dendrimer-immobilized surface.

    abstract::Understanding mechanisms that govern cell fate determination of human induced pluripotent stem cells (hiPSCs) could assist in maintenance of the undifferentiated state during cell expansion. We used polyamidoamine dendrimer surfaces with first-generation (G1), third-generation (G3) and fifth-generation (G5) of dendron...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.03.085

    authors: Kim MH,Kino-oka M

    更新日期:2014-07-01 00:00:00

  • Generation of an in vitro 3D PDAC stroma rich spheroid model.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibr...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.08.041

    authors: Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

    更新日期:2016-11-01 00:00:00

  • Three-dimensional microstructured tissue scaffolds fabricated by two-photon laser scanning photolithography.

    abstract::Current tissue engineering scaffolds fabricated via solvent casting and porogen leaching methods suffer from the lack of control over parameters such as interconnectivity and pore geometry, properties that are a function of the fabrication process. The progress of tissue engineering would thus benefit from the ability...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2010.06.029

    authors: Hsieh TM,Ng CW,Narayanan K,Wan AC,Ying JY

    更新日期:2010-10-01 00:00:00

  • Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

    abstract::In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cel...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2017.03.008

    authors: Ragelle H,Naba A,Larson BL,Zhou F,Prijić M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

    更新日期:2017-06-01 00:00:00

  • Thermally responsive core-shell nanoparticles self-assembled from cholesteryl end-capped and grafted polyacrylamides:; drug incorporation and in vitro release.

    abstract::The thermally responsive cholesteryl end-capped poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) and cholesteryl grafted poly[N-isopropylacrylamide-co-N-(hydroxymethyl) acrylamide] amphiphilic polymers were synthesized and utilized to encapsulate cyclosporin A (CyA) and indomethacin (IND) within core-shell nanopa...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2003.10.095

    authors: Chaw CS,Chooi KW,Liu XM,Tan CW,Wang L,Yang YY

    更新日期:2004-08-01 00:00:00

  • Temporally degradable collagen-mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells.

    abstract::Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical complexity of articular cartilage is through the use of recombinant bacterial collagens...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2016.05.011

    authors: Parmar PA,Skaalure SC,Chow LW,St-Pierre JP,Stoichevska V,Peng YY,Werkmeister JA,Ramshaw JA,Stevens MM

    更新日期:2016-08-01 00:00:00

  • Synthesis, characterization, and blood compatibility of polyamidoamines copolymers.

    abstract::This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N'-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to th...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(03)00122-4

    authors: Dey RK,Ray AR

    更新日期:2003-08-01 00:00:00

  • Differentiation of liver progenitor cell line to functional organotypic cultures in 3D nanofibrillar cellulose and hyaluronan-gelatin hydrogels.

    abstract::Physiologically relevant hepatic cell culture models must be based on three-dimensional (3D) culture of human cells. However, liver cells are generally cultured in two-dimensional (2D) format that deviates from the normal in vivo morphology. We generated 3D culture environment for HepaRG liver progenitor cells using w...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.03.020

    authors: Malinen MM,Kanninen LK,Corlu A,Isoniemi HM,Lou YR,Yliperttula ML,Urtti AO

    更新日期:2014-06-01 00:00:00

  • The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro.

    abstract::The effects of chitin [(1 --> 4)-2-acetamido-2-deoxy-beta-D-glucan] and its partially deacetylated derivatives, chitosans, on the proliferation of human dermal fibroblasts and keratinocytes were examined in vitro. Chitosans with relatively high degrees of deacetylation strongly stimulated fibroblast proliferation whil...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(01)00042-4

    authors: Howling GI,Dettmar PW,Goddard PA,Hampson FC,Dornish M,Wood EJ

    更新日期:2001-11-01 00:00:00

  • Potent killing of HBV-related hepatocellular carcinoma by a chimeric protein of anti-HBsAg single-chain antibody and truncated Bid.

    abstract::Targeted therapy is needed for hepatitis B virus (HBV)-mediated hepatocellular carcinoma (HCC) which shows overexpression of HBV surface antigen (HBsAg). We previously developed scFv15, a human single-chain antibody against HBsAg. Here we tested the strategic feasibility of scFv15-mediated delivery of apoptotic effect...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2013.03.046

    authors: Yan B,Ouyang Q,Zhao Z,Cao F,Wang T,Jia X,Meng Y,Jiang S,Liu J,Chen R,Jia L,Zhang R,Wen W,Jin B,Chen S,Zhao J,Yang A

    更新日期:2013-07-01 00:00:00

  • The role of MMP-I up-regulation in the increased compliance in muscle-derived stem cell-seeded small intestinal submucosa.

    abstract::We have previously observed that muscle-derived stem cells (MDSC) seeded onto porcine small intestinal submucosa (SIS) increase the mechanical compliance of the engineered tissue construct [Lu SH, Sacks MS, Chung SY, Gloeckner DC, Pruchnic R, Huard J, et al. Biaxial mechanical properties of muscle-derived cell seeded ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2005.10.011

    authors: Long RA,Nagatomi J,Chancellor MB,Sacks MS

    更新日期:2006-04-01 00:00:00

  • The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat.

    abstract::Combined treatment using nonviral agent-mediated enzyme/prodrug therapy and immunotherapy had been proposed as a powerful alternative method of cancer therapy. The present study was aimed to evaluate the cytotoxicity in vitro and the therapeutic efficacy in vivo when the cytosine deaminase/5-fluorocytosine (CD/5-FC) a...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2009.04.011

    authors: Liang B,He ML,Chan CY,Chen YC,Li XP,Li Y,Zheng D,Lin MC,Kung HF,Shuai XT,Peng Y

    更新日期:2009-08-01 00:00:00

  • Chitosan cross-linked with Mo(VI) polyoxyanions: a new gelling system.

    abstract::A procedure for preparing homogeneous chitosan gels by in situ molybdate cross-linking is described. The gels are obtained by dispersing solid MoO3 in a buffered chitosan solution and the polymer is cross-linked by formation of heavily negatively charged molybdate polyoxyanions. The resulting ionic gels are very trans...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(92)90032-j

    authors: Draget KI,Vårum KM,Moen E,Gynnild H,Smidsrød O

    更新日期:1992-01-01 00:00:00

  • Long-term culture of embryonic rat cardiomyocytes on an organosilane surface in a serum-free medium.

    abstract::Potential applications of engineered, functional, cardiac muscle extends from basic research through drug discovery to engineering heart tissue for transplantation. One of the central questions in cardiac tissue engineering is to understand and control the complex interactions between the cardiac muscle cells and thei...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.01.020

    authors: Das M,Molnar P,Gregory C,Riedel L,Jamshidi A,Hickman JJ

    更新日期:2004-11-01 00:00:00

  • Synthesis and characterization of a new vertebroplasty cement based on gold-containing PMMA microspheres.

    abstract::There are a number of drawbacks to incorporating large concentrations of barium sulfate (BaSO4) as the radiopacifier in PMMA-based bone cements for percutaneous vertebroplasty. These include adverse effects on injectability, viscosity profile, setting time, mechanical properties of the cement and bone resorption. We h...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.12.024

    authors: Jacobs E,Saralidze K,Roth AK,de Jong JJ,van den Bergh JP,Lataster A,Brans BT,Knetsch ML,Djordjevic I,Willems PC,Koole LH

    更新日期:2016-03-01 00:00:00

  • Regeneration of ovine articular cartilage defects by cell-free polymer-based implants.

    abstract::The aim of our study was the evaluation of a cell-free cartilage implant that allows the recruitment of mesenchymal stem and progenitor cells by chemo-attractants and subsequent guidance of the progenitors to form cartilage repair tissue after microfracture. Chemotactic activity of human serum on human mesenchymal pro...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2007.09.005

    authors: Erggelet C,Neumann K,Endres M,Haberstroh K,Sittinger M,Kaps C

    更新日期:2007-12-01 00:00:00

  • Expression of bone matrix proteins during de novo bone formation using a bovine collagen and platelet-rich plasma (prp)--an immunohistochemical analysis.

    abstract::This animal study (domestic pig) examined the bone formation after filling defined defects with autogenous bone or a collagen lyophilisat in combination with Platelet-rich-plasma (PRP) by evaluating bone matrix proteins. Six groups, both materials with and without PRP in two concentrations (+ 1, + 2) were compared to ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2004.07.041

    authors: Thorwarth M,Rupprecht S,Falk S,Felszeghy E,Wiltfang J,Schlegel KA

    更新日期:2005-05-01 00:00:00

  • A microwell array system for stem cell culture.

    abstract::Directed embryonic stem (ES) cell differentiation is a potentially powerful approach for generating a renewable source of cells for regenerative medicine. Typical in vitro ES cell differentiation protocols involve the formation of ES cell aggregate intermediates called embryoid bodies (EBs). Recently, we demonstrated ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2007.10.030

    authors: Moeller HC,Mian MK,Shrivastava S,Chung BG,Khademhosseini A

    更新日期:2008-02-01 00:00:00

  • Characterization of metabolic changes associated with the functional development of 3D engineered tissues by non-invasive, dynamic measurement of individual cell redox ratios.

    abstract::Non-invasive approaches to assess tissue function could improve significantly current methods to diagnose diseases and optimize engineered tissues. In this study, we describe a two-photon excited fluorescence microscopy approach that relies entirely on endogenous fluorophores to dynamically quantify functional metabol...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.04.024

    authors: Quinn KP,Bellas E,Fourligas N,Lee K,Kaplan DL,Georgakoudi I

    更新日期:2012-07-01 00:00:00

  • Comparative proteomic analysis of endothelial cells progenitor cells derived from cord blood- and peripheral blood for cell therapy.

    abstract::Vasculopathy due to ischemia in damaged tissues is a major cause of morbidity and mortality. To treat these conditions, endothelial progenitor cells (EPCs) from various sources, such as umbilical cord or peripheral blood, have been the focus of the regenerative medicine field due to their proliferative and vasculogeni...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2012.11.017

    authors: Kim J,Jeon YJ,Kim HE,Shin JM,Chung HM,Chae JI

    更新日期:2013-02-01 00:00:00

  • Neutrophil polarization and immunoelectrophoresis assays in the study of complement activation by biomaterials.

    abstract::The neutrophil polarization assay, a technique used to measure chemotaxis, was adapted to examine complement activation. Complement activation in serum which had been incubated with metallic and polymeric biomaterials was examined using the neutrophil polarization assay and immunoelectrophoresis assay. In agreement wi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(91)90060-n

    authors: Remes A,Williams DF

    更新日期:1991-08-01 00:00:00

  • A citric acid-based hydroxyapatite composite for orthopedic implants.

    abstract::We describe a novel approach to process bioceramic microparticles and poly(diol citrates) into bioceramic-elastomer composites for potential use in orthopedic surgery. The composite consists of the biodegradable elastomer poly(1,8-octanediol-citrate) (POC) and the bioceramic hydroxyapatite (HA). The objective of this ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2006.07.042

    authors: Qiu H,Yang J,Kodali P,Koh J,Ameer GA

    更新日期:2006-12-01 00:00:00

  • Chemical treatment and tissue selection: factors that influence the mechanical behaviour of porcine pericardium.

    abstract::Calcification and mechanical failure are the major causes of the loss of cardiac bioprostheses. The chemical treatments used to stabilize the tissue employed are considered to play a fundamental role in the development of these two phenomena, although the problem is multifactorial and the underlying causes are yet to ...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(01)00019-9

    authors: Garcia Páez JM,Jorge-Herrero E,Carrera A,Millán I,Rocha A,Calero P,Cordón A,Salvador J,Sainz N,Méndez J,Castillo-Olivares JL

    更新日期:2001-10-01 00:00:00

  • Adsorption of plasma proteins on polyethylene oxide-modified lipid bilayers studied by total internal reflection fluorescence.

    abstract::Distearoylphophatidylcholine (DSPC) mixed with various mole percentages of polyethylene oxide (number average molecular weight 2000)-grafted distearoylphosphatidylethanolamine (PEO2000-DSPE) were deposited on DSPE-coated quartz surfaces by the Langmuir-Blodgett deposition. Structural transitions in PEO2000 from pancak...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(00)00004-1

    authors: Xu Z,Marchant RE

    更新日期:2000-05-01 00:00:00

  • Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes.

    abstract::Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular cell types. This guided transpo...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2015.11.016

    authors: Wayteck L,Dewitte H,De Backer L,Breckpot K,Demeester J,De Smedt SC,Raemdonck K

    更新日期:2016-01-01 00:00:00

  • Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits.

    abstract::Porous calcium phosphate ceramics consisting of hydroxyapatite (HA) and tricalcium phosphate (TCP) with different HA to TCP ratio were implanted intramuscularly in rabbits for six months in order to carry out a comparative study on osteogenic activity of the ceramics. Bone formation was detected only in HT73 (HA to TC...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/s0142-9612(01)00119-3

    authors: Kurashina K,Kurita H,Wu Q,Ohtsuka A,Kobayashi H

    更新日期:2002-01-01 00:00:00

  • The transdermal inhibition of melanogenesis by a cell-membrane-permeable peptide delivery system based on poly-arginine.

    abstract::Topical therapy is the most favored form of treatment for whitening against hyper-pigmentation and sunburn because it lends itself to self-administration, patient compliance and an absence of systemic adverse effects. However, high-molecular-weight, hydrophilic chemicals are difficult to use as transdermal delivery dr...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2014.01.052

    authors: Ookubo N,Michiue H,Kitamatsu M,Kamamura M,Nishiki T,Ohmori I,Matsui H

    更新日期:2014-05-01 00:00:00

  • Bone microstructure by collagenase etching.

    abstract::A novel technique has been developed for microstructural studies of bone. The spatial organizations of the mineral and collagen fibres in bone have been a matter of discussion for some time, with numerous diverse observations arising from various preparative techniques. In this latest investigation details of the mine...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/0142-9612(85)90002-x

    authors: Green M,Isaac DH,Jenkins GM

    更新日期:1985-05-01 00:00:00

  • Plasma-sprayed hydroxyapatite+titania composite bond coat for hydroxyapatite coating on titanium substrate.

    abstract::A two-layer hydroxyapatite (HA)/HA+TiO(2) bond coat composite coating (HTH coating) on titanium was fabricated by plasma spraying. The HA+TiO(2) bond coat (HTBC) consists of 50 vol% HA and 50 vol% TiO(2) (HT). The microstructural characterization of the HTH coatings before and after heat treatment was conducted by usi...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2003.10.092

    authors: Lu YP,Li MS,Li ST,Wang ZG,Zhu RF

    更新日期:2004-08-01 00:00:00

  • Selective uptake of surface-modified phospholipid vesicles by bone marrow macrophages in vivo.

    abstract::An advantage of using vesicles (liposomes) as drug delivery carriers is that their pharmacokinetics can be controlled by surface characteristics, which can permit specific delivery of the encapsulated agents to organs or cells in vivo. Here we report a vesicle formulation which targets the bone marrow after intravenou...

    journal_title:Biomaterials

    pub_type: 杂志文章

    doi:10.1016/j.biomaterials.2007.01.041

    authors: Sou K,Goins B,Takeoka S,Tsuchida E,Phillips WT

    更新日期:2007-06-01 00:00:00