Abstract:
:Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood. The local temperature of the NIR-irradiated PANI-GCS NPs is estimated to be approximately 5 °C higher than their ambient tissue temperature, ensuring specific and direct heating of their aggregated bacteria; hence, damage to tissue is reduced and wound healing is accelerated. The above results demonstrate that PANI-GCS NPs are practical for use in the photothermal ablation of focal infections.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Korupalli C,Huang CC,Lin WC,Pan WY,Lin PY,Wan WL,Li MJ,Chang Y,Sung HWdoi
10.1016/j.biomaterials.2016.11.045subject
Has Abstractpub_date
2017-02-01 00:00:00pages
1-9eissn
0142-9612issn
1878-5905pii
S0142-9612(16)30669-Xjournal_volume
116pub_type
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