Abstract:
:Modified high shear homogenization and ultrasound techniques were employed to produce solid lipid nanoparticles (SLNs). Model drug mifepristone had been incorporated in SLNs. The mean particle size measured by laser diffractometry (LD) was found to be 106 nm with a narrow particle distribution of polydispersity index, 0.278. Differential scanning calorimetry and X-ray diffraction measurements suggested that the majority of the SLNs were less ordered arrangement of crystals, and this was favorable for increasing the drug loading capacity. The drug entrapment efficiency (EE%) of SLNs was more than 87 percent and showed relatively long-term physical stability as the leakage was very small after being stored for one month. Therefore, seemed this modified method could prepare high quality SLNs loading lipophilic drugs. It is a simple, available and effective method to produce SLNs.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Hou D,Xie C,Huang K,Zhu Cdoi
10.1016/s0142-9612(02)00578-1keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
1781-5issue
10eissn
0142-9612issn
1878-5905pii
S0142961202005781journal_volume
24pub_type
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