Abstract：
:Tetragonal zirconia polycrystal (TZP) is a new interesting ceramic for the manufacture of medical devices. Its wide use in orthopedic and odontoiatric implants was limited till now by the high chemical and radiochemical impurities of the raw materials. Purification processes now available allow to obtain high purity ceramic grade powders suitable for TZP ceramics manufacture, even if their possible mutagenic and transforming effects are still unclear. The aim of this work is to study in vitro the mutagenic and oncogenic effects of a new zirconia ceramic stabilized by yttria (Y-TZP). This ceramic was sintered from high purity powders obtained by a process developed under a project carried out within the Brite EuRam programme. For comparison, ceramics made from unpurified zirconia powder were also tested. Fibroblasts irradiated by a linear accelerator were used as positive control. The results obtained show that Y-TZP ceramic does not elicit either mutagenic or transforming effect on C3H/10T(1/2) (10T(1/2)) cells and demonstrate that ceramic from high purity powders can be considered suitable for biomedical applications from the point of view of the effects of its radioactive impurity content.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Covacci V,Bruzzese N,Maccauro G,Andreassi C,Ricci GA,Piconi C,Marmo E,Burger W,Cittadini Adoi
10.1016/s0142-9612(98)00182-3keywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
371-6issue
4eissn
0142-9612issn
1878-5905pii
S0142-9612(98)00182-3journal_volume
20pub_type
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