Single cell derived spheres of umbilical cord mesenchymal stem cells enhance cell stemness properties, survival ability and therapeutic potential on liver failure.

abstract：:Tissue engineering therapies targeted at nerve regeneration in spinal cord injuries (SCI) have broad social and economic benefits to the American population. Due to the complicated pathophysiology of SCI, there are very few options available for functional regeneration of the spinal column. Nanotechnology offers inter...

journal_title：Biomaterials

authors： Bechara SL,Judson A,Popat KC

更新日期：2010-05-01 00:00:00

abstract：:Small-diameter vascular grafts made of biomedical polytetrafluoroethylene (PTFE) suffer from the poor long-term patency rate originating from thrombosis and intimal hyperplasia, which can be ascribed to the insufficient endothelialization and chronic inflammation of the materials. Hence, bio-functionalization of PTFE ...

journal_title：Biomaterials

authors： Gao A,Hang R,Li W,Zhang W,Li P,Wang G,Bai L,Yu XF,Wang H,Tong L,Chu PK

更新日期：2017-09-01 00:00:00

abstract：:Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for cancer applications owing to their innate ability to home to tumors. However, traditional stem cell-based gene therapies are hampered by our current inability to control w...

journal_title：Biomaterials

authors： Yin PT,Shah S,Pasquale NJ,Garbuzenko OB,Minko T,Lee KB

更新日期：2016-03-01 00:00:00

abstract：:The role of albumin in the mineralisation process of commercial hydroxyapatite (HAp) and synthesised biphasic (HAp-tricalcium phosphate) ceramics in a bufferless simulated inorganic plasma (HBSS) was investigated by conventional in vitro tests and static and dynamic wettability measurements. Albumin was either pre-ads...

journal_title：Biomaterials

authors： Marques PA,Serro AP,Saramago BJ,Fernandes AC,Magalhães MC,Correia RN

更新日期：2003-02-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:Biomedical alloys may release nickel ions during corrosion phenomena and, in addition to their interaction with oral tissues, these ions may also influence characteristic properties of the immune system cells. The aim of this study was to evaluate the effect of nickel chloride on the expression of functionally distinc...

journal_title：Biomaterials

authors： D'Antò V,Eckhardt A,Hiller KA,Spagnuolo G,Valletta R,Ambrosio L,Schmalz G,Schweikl H

更新日期：2009-03-01 00:00:00

abstract：:Based on the hydrophobic interaction with biomembranes, PFVYLI (PFV), a hydrophobic penetration peptide (HPP), was initially introduced to modify doxorubicin-loaded stealth-sustained liposomes (PFV-SSLs-DOX) against different breast cancer cell phenotypes irrespective of their receptor expression or antigen presence. ...

journal_title：Biomaterials

authors： Cai D,Gao W,He B,Dai W,Zhang H,Wang X,Wang J,Zhang X,Zhang Q

更新日期：2014-02-01 00:00:00

abstract：:The successful delivery of anti-cancer drugs relies on the simultaneous capability to actively target a specific location, a sufficient lifetime in the active form in the circulation, and traceability and quantification of drug distribution via in vivo medical imaging. Herein, a highly magnetic nanocarrier (HMNC) comp...

journal_title：Biomaterials

authors： Yang HW,Hua MY,Liu HL,Huang CY,Tsai RY,Lu YJ,Chen JY,Tang HJ,Hsien HY,Chang YS,Yen TC,Chen PY,Wei KC

更新日期：2011-09-01 00:00:00

abstract：:Micro/nanotopographical modification of biomaterials constitutes a promising approach to direct stem cell osteogenic differentiation to promote osseointegration. In this work, titania nanotubes (NTs) 25 and 80 nm in size with the acid-etched Ti topography (AcidTi) and hierarchical hybrid micropitted/nanotubular topogr...

journal_title：Biomaterials

authors： Zhao L,Liu L,Wu Z,Zhang Y,Chu PK

更新日期：2012-03-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) has been extensively investigated to promote vascularization at damaged or diseased sites and in tissue implants. Here we are interested in determining if the manner in which VEGF is presented from a scaffold to endothelial cells influences the architecture of the blood vessel...

journal_title：Biomaterials

authors： Anderson SM,Siegman SN,Segura T

更新日期：2011-10-01 00:00:00

abstract：:New light-activation units equipped with high-illuminant blue light-emitting diodes (LEDs) have recently been proposed as a replacement for the halogen units that are widely used in dentistry to polymerize light-cured resins. The photoinitiators in light-cured dental resins, typified by the camphorquinone (CQ)/amine p...

journal_title：Biomaterials

authors： Teshima W,Nomura Y,Tanaka N,Urabe H,Okazaki M,Nahara Y

更新日期：2003-05-01 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:In vivo and in vitro degradation of high molecular weight poly(L-lactide) used for internal bone fixation has been investigated. Within 3 months as-polymerized, microporous PLLA (Mv = 6.8-9.5 X 10(5] exhibited a massive strength-loss (sigma b = 68-75 MPa to sigma b = 4 MPa) and decrease of Mv (90-95%). At week 39, the...

journal_title：Biomaterials

authors： Leenslag JW,Pennings AJ,Bos RR,Rozema FR,Boering G

更新日期：1987-07-01 00:00:00

abstract：:The porous TiO2/perlite composite Ecopore is a synthetic biomaterial with possible clinical application in bone substitution. In our previous work, we demonstrated that surface modification of Ecopore with fibronectin (FN) enhanced spreading and growth of human osteoblasts in vitro. In the present study, we implanted ...

journal_title：Biomaterials

authors： Erli HJ,Rüger M,Ragoss C,Jahnen-Dechent W,Hollander DA,Paar O,von Walter M

更新日期：2006-03-01 00:00:00

abstract：:Effective antimicrobial agents are important arsenals in our perennial fight against communicable diseases, hospital-acquired and surgical site multidrug-resistant infections. In this study, we devise a strategy for the development of highly efficacious and skin compatible yet inexpensive water-soluble macromolecular ...

journal_title：Biomaterials

authors： Liu S,Ono RJ,Wu H,Teo JY,Liang ZC,Xu K,Zhang M,Zhong G,Tan JP,Ng M,Yang C,Chan J,Ji Z,Bao C,Kumar K,Gao S,Lee A,Fevre M,Dong H,Ying JY,Li L,Fan W,Hedrick JL,Yang YY

更新日期：2017-05-01 00:00:00

abstract：:Three-dimensional gelatin-chondroitin 6 sulphate-hyanuronic acid (gelatin-C6S-HA) biomatrices were used as the scaffold to investigate the phenotypic and molecular expression of basement membrane (BM) and extracellular matrix (ECM) proteins in vitro. The cells were cultured in three different culture conditions: kerat...

journal_title：Biomaterials

authors： Wang TW,Sun JS,Huang YC,Wu HC,Chen LT,Lin FH

更新日期：2006-10-01 00:00:00

abstract：:Metal sensitivity (MS) reactions to implant metals represent a rare but well-documented complication following total joint arthroplasty (TJA). Although 20-25% of post-TJA patients develop MS, only a few highly susceptible patients (< 1%) exhibit symptoms. Whether surgeons should perform screening for MS is currently a...

journal_title：Biomaterials

authors： Niki Y,Matsumoto H,Otani T,Yatabe T,Kondo M,Yoshimine F,Toyama Y

更新日期：2005-03-01 00:00:00

abstract：:Si, Mg-substituted hydroxyapatites, alone and co-substituted, have been prepared to obtain biomaterials having an improved biocompatibility. From FT-IR, XRD and ICP analyses, it was confirmed that single phases of hydroxyapatite substituted by Si alone or co-substituted by Si, Mg. The XRD data indicated the absence of...

journal_title：Biomaterials

authors： Kim SR,Lee JH,Kim YT,Riu DH,Jung SJ,Lee YJ,Chung SC,Kim YH

更新日期：2003-04-01 00:00:00

abstract：:Current materials used for maxillofacial prostheses are far from ideal and there is a need for new improved materials which better simulate the tissues they are replacing. This study was based on a mixed experimental/analytical/numerical approach. A new polymeric material was developed to provide a better alternative ...

journal_title：Biomaterials

authors： Bellamy K,Limbert G,Waters MG,Middleton J

更新日期：2003-12-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, the immobilization of hTM was investigated in detail using surface modified polymers. As the basis of imm...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Maruyama I,Akashi M

更新日期：1994-11-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells protect vertebrates by killing infected or transformed cells using granzyme B (GrB) to induce apoptosis. However, GrB-induced apoptosis of target cells causes inflammatory disease and chronic transplant rejection and so is an important disease target. The aim...

journal_title：Biomaterials

authors： Cheng W,Yang C,Hedrick JL,Williams DF,Yang YY,Ashton-Rickardt PG

更新日期：2013-05-01 00:00:00

abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

journal_title：Biomaterials

authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

更新日期：2012-10-01 00:00:00

abstract：:A surface functionalization strategy that produces substrates with well-controlled ligand density is critical to investigating the role of cell-substrate interactions in regulating cell adhesion, viability, migration, proliferation and differentiation. Towards this end, we have designed and synthesized a triblock prot...

journal_title：Biomaterials

authors： Fischer SE,Liu X,Mao HQ,Harden JL

更新日期：2007-08-01 00:00:00

abstract：:Water uptake characteristics of BisGMA-based composites incorporating untreated and surface-treated hydroxyapatite (HA) with a silane coupling agent have been investigated. The water absorption and desorption behaviour of these composites obeyed the classical diffusion theory. The diffusion coefficients of the composi...

journal_title：Biomaterials

authors： Santos C,Clarke RL,Braden M,Guitian F,Davy KW

更新日期：2002-04-01 00:00:00

abstract：:Silica nanoparticles (SiO2-NPs) has been extensively exploited in biomedical fields and mostly designed to enter the circulatory system, however, few studies focused on the potential adverse effects of SiO2-NPs exposure on the blood-brain barrier (BBB) that serves as a critical barrier between the central nervous syst...

journal_title：Biomaterials

authors： Liu X,Sui B,Sun J

更新日期：2017-03-01 00:00:00

abstract：:In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to reduce in-stent restenosis, the nonspecific inhibitory effects of anti-proliferative drugs, such as rapamycin, result in delayed re-endothelialization and fatal late stent t...

journal_title：Biomaterials

authors： Zhang H,Ren KF,Chang H,Wang JL,Ji J

更新日期：2017-02-01 00:00:00

abstract：:Photoacoustic tomography (PAT) also referred to as optoacoustic tomography (OAT) is a hybrid imaging modality that employs nonionizing optical radiation and ultrasonic detection. Here, we describe the application of a new class of optical contrast agents based on mesoscopic hollow gold nanospheres (HAuNS) to PAT. HAuN...

journal_title：Biomaterials

authors： Lu W,Huang Q,Ku G,Wen X,Zhou M,Guzatov D,Brecht P,Su R,Oraevsky A,Wang LV,Li C

更新日期：2010-03-01 00:00:00

abstract：:We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost constant. Our observations rev...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Yamane S,Hashimoto M,Takatori Y,Ishihara K

更新日期：2013-10-01 00:00:00

abstract：:Multi-layered poly(glycerol-sebacate) (PGS) scaffolds with controlled pore microarchitectures were fabricated, combined with heart cells, and cultured with perfusion to engineer contractile cardiac muscle constructs. First, one-layered (1L) scaffolds with accordion-like honeycomb shaped pores and elastomeric mechanica...

journal_title：Biomaterials

authors： Park H,Larson BL,Guillemette MD,Jain SR,Hua C,Engelmayr GC Jr,Freed LE

更新日期：2011-03-01 00:00:00