Abstract:
:The role of albumin in the mineralisation process of commercial hydroxyapatite (HAp) and synthesised biphasic (HAp-tricalcium phosphate) ceramics in a bufferless simulated inorganic plasma (HBSS) was investigated by conventional in vitro tests and static and dynamic wettability measurements. Albumin was either pre-adsorbed or solubilised in HBSS. It was found that calcium complexation by albumin plays a key role in early mineralisation kinetics, so that mineralisation is favoured when albumin is pre-adsorbed and hindered when it is dissolved in HBSS. In the biphasic ceramic this picture is complicated by the fact that albumin, in solution, seems to promote the dissolution of tricalcium phosphate, and simultaneously compete for calcium with the ceramic. It also appears that albumin has a stabilising effect of octacalcium phosphate present in deposits on commercial HAp. The same effect may be present in the case of the biphasic ceramic, at earlier mineralisation times, when octacalcium phosphate appears as a precursor of HAp. Octacalcium phosphate formation on commercial apatite is accompanied by carbonate substitution in phosphate positions.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Marques PA,Serro AP,Saramago BJ,Fernandes AC,Magalhães MC,Correia RNdoi
10.1016/s0142-9612(02)00358-7keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
451-60issue
3eissn
0142-9612issn
1878-5905pii
S0142961202003587journal_volume
24pub_type
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