Abstract：
:In vivo and in vitro degradation of high molecular weight poly(L-lactide) used for internal bone fixation has been investigated. Within 3 months as-polymerized, microporous PLLA (Mv = 6.8-9.5 X 10(5] exhibited a massive strength-loss (sigma b = 68-75 MPa to sigma b = 4 MPa) and decrease of Mv (90-95%). At week 39, the first signs of resorption were evident (mass-loss 5 wt%). Except for dynamically loaded bone plates no differences between in vivo and in vitro degradation of PLLA were observed. The increase of crystallinity of PLLA upon degradation (up to 83%) is likely to be attributed to recrystallization of tie-chain segments. A more ductile PLLA exhibiting a lower rate of degradation was prepared by extraction of low molecular weight compounds with ethyl acetate.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Leenslag JW,Pennings AJ,Bos RR,Rozema FR,Boering Gdoi
10.1016/0142-9612(87)90121-9subject
Has Abstractpub_date
1987-07-01 00:00:00pages
311-4issue
4eissn
0142-9612issn
1878-5905pii
0142-9612(87)90121-9journal_volume
8pub_type
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