Abstract：
:Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional polyester-based hydrogels. In vivo biocompatibility studies revealed that the in situ formed gels in the subcutaneous layer last for ≈ 21 days, and H&E staining study suggested acceptable biocompatibility of our materials in vivo. Then the hydrogels were tried as injectable implants to encapsulate antitumor drug, paclitaxel (PTX), to assess the in situ anti-tumoral activity using liver cancer xenograft model. The results demonstrated that the PTX-incorporated hydrogels could efficiently suppress the tumor growth, and did not result in obvious damage to normal organs. Therefore, the polypeptide-based thermosensitive hydrogels designed in the present study have great potential to serve as an effective platform for localized anti-cancer drug delivery.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Cheng Y,He C,Ding J,Xiao C,Zhuang X,Chen Xdoi
10.1016/j.biomaterials.2013.09.064subject
Has Abstractpub_date
2013-12-01 00:00:00pages
10338-47issue
38eissn
0142-9612issn
1878-5905pii
S0142-9612(13)01164-2journal_volume
34pub_type
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