Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles.

abstract：:We report the fabrication of a one-pot antigen system that delivers antigen to dendritic cells (DCs) and tracks their in vivo migration after injection. Multifunctional polymer nanoparticles containing ovalbumin protein, magnetic resonance imaging contrast agents (iron oxide nanoparticles), and near-infrared fluoropho...

journal_title：Biomaterials

authors： Noh YW,Jang YS,Ahn KJ,Lim YT,Chung BH

更新日期：2011-09-01 00:00:00

abstract：:We have developed an ion-sensing nanoparticle that is comprised of a superparamagnetic iron oxide (SPIO) core encapsulated with a porous silica shell. The latter can be readily anchored with ligands capable of coordinating with positron-emitting metal. Evidently, this nanoparticle has a great potential for use in cell...

journal_title：Biomaterials

authors： Patel D,Kell A,Simard B,Deng J,Xiang B,Lin HY,Gruwel M,Tian G

更新日期：2010-04-01 00:00:00

abstract：:Nervous tissue lesions are an important social concern due to their increasing prevalence and their high sanitary costs. Their treatment still remains a challenge because of the reduced ability of nervous tissue to regenerate, its intrinsic structural and functional complexity and the rapid formation of fibroglial sca...

journal_title：Biomaterials

authors： Serrano MC,Nardecchia S,García-Rama C,Ferrer ML,Collazos-Castro JE,del Monte F,Gutiérrez MC

更新日期：2014-02-01 00:00:00

abstract：:The conventional biomimetic apatite coating process can be accelerated by immersing substrates into concentrated simulated body fluid (5 x SBF) at 37 degrees C to form an initial coating of apatite precursor spheres, and transform the precursors into plate-like apatite structures. Depending on processing parameters, d...

journal_title：Biomaterials

authors： Chou YF,Huang W,Dunn JC,Miller TA,Wu BM

更新日期：2005-01-01 00:00:00

abstract：:Biomedical alloys may release nickel ions during corrosion phenomena and, in addition to their interaction with oral tissues, these ions may also influence characteristic properties of the immune system cells. The aim of this study was to evaluate the effect of nickel chloride on the expression of functionally distinc...

journal_title：Biomaterials

authors： D'Antò V,Eckhardt A,Hiller KA,Spagnuolo G,Valletta R,Ambrosio L,Schmalz G,Schweikl H

更新日期：2009-03-01 00:00:00

abstract：:While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or lipid components. Her...

journal_title：Biomaterials

authors： Jackson MA,Bedingfield SK,Yu F,Stokan ME,Miles RE,Curvino EJ,Hoogenboezem EN,Bonami RH,Patel SS,Kendall PL,Giorgio TD,Duvall CL

更新日期：2019-02-01 00:00:00

abstract：:Membranes, clinically used to improve bone regeneration according to the osteopromotion principle, have primarily been made of expanded polytetrafluoroethylene (Gore-Tex Membrane). Recently, different types of biodegradable membranes have become available. This investigation explored the osteopromotive potential of 10...

journal_title：Biomaterials

authors： Zellin G,Gritli-Linde A,Linde A

更新日期：1995-05-01 00:00:00

abstract：:A series of hydrogels composed of varying fractions of dodecyl methacrylate (DM) and 2,3-dihydroxypropyl methacrylate (GM) were prepared using ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. The study found that for a series of gels with the same monomer ratio, bulk hydration could be controlled by ...

journal_title：Biomaterials

authors： Haigh R,Rimmer S,Fullwood NJ

更新日期：2000-04-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:Poly(γ-4-((2-(piperidin-1-yl)ethyl)aminomethyl)benzyl-l-glutamate) (PPABLG), a cationic helical polypeptide, has been recently developed by us as an effective non-viral gene delivery vector. In attempts to elucidate the effect of molecular architecture on the gene delivery efficiencies and thereby identify a potential...

journal_title：Biomaterials

authors： Yin L,Song Z,Kim KH,Zheng N,Tang H,Lu H,Gabrielson N,Cheng J

更新日期：2013-03-01 00:00:00

abstract：:A PCL/hydrogel construct that would mimic the structural organization, biochemistry and anatomy of meniscus was engineered. The compressive (380 ± 40 kPa) and tensile modulus (18.2 ± 0.9 MPa) of the PCL scaffolds were increased significantly when constructs were printed with a shifted design and circumferential strand...

journal_title：Biomaterials

authors： Bahcecioglu G,Bilgen B,Hasirci N,Hasirci V

更新日期：2019-10-01 00:00:00

abstract：:Hyaluronan (HL), a naturally occurring glycosaminoglycan, has been chemically modified through the esterification of its carboxylic groups with different types of alcohol. The physico-chemical properties of these new biopolymers allow the preparation of many biomaterials which may be used in several medical applicatio...

journal_title：Biomaterials

authors： Benedetti L,Cortivo R,Berti T,Berti A,Pea F,Mazzo M,Moras M,Abatangelo G

更新日期：1993-12-01 00:00:00

abstract：:Cell attachment, proliferation and differentiation on different materials depend largely on the surface properties of the materials. This study sheds light on the mechanism by which the modulation of the chemical composition of calcium silicate cements with different Si/Ca molar ratios could produce different cell res...

journal_title：Biomaterials

authors： Shie MY,Ding SJ

更新日期：2013-09-01 00:00:00

abstract：:Collagen has been widely used for tissue engineering. Here, we applied bioactive laminin-derived peptides as an additive for collagen, laminin-111, and fibronectin matrices resulting in peptide/collagen, peptide/laminin-111, and peptide/fibronectin matrices. Several syndecan-binding peptides, including AG73 (RKRLQVQLS...

journal_title：Biomaterials

authors： Yamada Y,Katagiri F,Hozumi K,Kikkawa Y,Nomizu M

更新日期：2011-07-01 00:00:00

abstract：:The reaction of calcium ions and organic phosphate ester monomer at varying pHs was examined. Above pH 10, poorly crystallized hydroxyapatite was formed, which had lower crystallinity than that synthesized with inorganic phosphate as a source of P under the same conditions. On the other hand, the results of X-ray diff...

journal_title：Biomaterials

authors： Okazaki M,Hattori M

更新日期：1989-03-01 00:00:00

abstract：:Biomaterials can potentially influence stem and progenitor cell proliferation and differentiation in both a positive and a negative way. Herein, we report on the expansion and differentiation of rat embryonic (E17) liver (RLC-18) cells on new bioactive membrane made of PEEK-WC-PU, whose surface was grafted with nitrog...

journal_title：Biomaterials

authors： Pavlica S,Piscioneri A,Peinemann F,Keller M,Milosevic J,Staeudte A,Heilmann A,Schulz-Siegmund M,Laera S,Favia P,De Bartolo L,Bader A

更新日期：2009-11-01 00:00:00

abstract：:A new system of single piece electrodes was applied to in vivo and in vitro measurements of anodic polarization of several alloys used in orthopaedic implants. The tested surface was scrutinized with a stereomicroscope after each experiment. This confirmed pit formation and excluded the possibility of other sudden inc...

journal_title：Biomaterials

authors： Nakayama Y,Yamamuro T,Kotoura Y,Oka M

更新日期：1989-08-01 00:00:00

abstract：:It is known that the organic molecules can provide an effective means to manipulate the surface properties of the biodegradable ceramic. There are two ways to modify the surface of the biodegradable ceramic by organic molecules. The first one is through surface adsorption but organic molecules will easily be washed ou...

journal_title：Biomaterials

authors： Dong GC,Sun JS,Yao CH,Jiang GJ,Huang CW,Lin FH

更新日期：2001-12-01 00:00:00

abstract：:Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans (GAGs) to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matr...

journal_title：Biomaterials

authors： Pieper JS,van Wachem PB,van Luyn MJA,Brouwer LA,Hafmans T,Veerkamp JH,van Kuppevelt TH

更新日期：2000-08-01 00:00:00

abstract：:The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxy-phenoxypropane):sebacic acid] 20:80 [P(CPP:Sa)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. Wi...

journal_title：Biomaterials

authors： Domb AJ,Rock M,Schwartz J,Perkin C,Yipchuk G,Broxup B,Villemure JG

更新日期：1994-07-01 00:00:00

abstract：:Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...

journal_title：Biomaterials

authors： Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

更新日期：2007-12-01 00:00:00

abstract：:The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

journal_title：Biomaterials

authors： Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

更新日期：1996-02-01 00:00:00

abstract：:Micro-computed tomography (micro-CT) is an emerging imaging modality, due to the low cost of the imagers as well as their efficiency in establishing high-resolution (1-100 μm) three-dimensional images of small laboratory animals and facilitating rapid, structural and functional in vivo visualization. However use of a ...

journal_title：Biomaterials

authors： Li X,Anton N,Zuber G,Zhao M,Messaddeq N,Hallouard F,Fessi H,Vandamme TF

更新日期：2013-01-01 00:00:00

abstract：:The study is focused on the evaluation of the potential bioadhesive behaviour of chitosan and thiolated chitosan (chitosan-TBA)-coated poly(isobutyl cyanoacrylates) (PIBCA) nanoparticles. Nanoparticles were obtained by radical emulsion polymerisation with chitosan of different molecular weight and with different propo...

journal_title：Biomaterials

authors： Bravo-Osuna I,Vauthier C,Farabollini A,Palmieri GF,Ponchel G

更新日期：2007-04-01 00:00:00

abstract：:This work developed a multimodal imaging system by co-encapsulating superparamagnetic iron oxides (IOs) and quantum dots (QDs) in the nanoparticles of poly (lactic acid) - d-α-tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS) for concurrent imaging of the magnetic resonance imaging (MRI) and the fluorescence im...

journal_title：Biomaterials

authors： Tan YF,Chandrasekharan P,Maity D,Yong CX,Chuang KH,Zhao Y,Wang S,Ding J,Feng SS

更新日期：2011-04-01 00:00:00

abstract：:The use of non-viral nanoparticulate systems for the delivery of therapeutic agents is receiving considerable attention for medical and pharmaceutical applications. This increasing interest results from the fact that these systems can be designed to meet specific physicochemical requirements, and they display low toxi...

journal_title：Biomaterials

authors： Chellat F,Merhi Y,Moreau A,Yahia L

更新日期：2005-12-01 00:00:00

abstract：:Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have hypothesized that utilization...

journal_title：Biomaterials

authors： Lee KY,Bouhadir KH,Mooney DJ

更新日期：2004-06-01 00:00:00

abstract：:The development of more selective delivery systems for cancer diagnosis and chemotherapy is one of the most important goals of current anticancer research. The purpose of this study is to evaluate various self-assembled nanoparticles as candidates to shuttle radionuclide and/or drugs into tumors and to investigate the...

journal_title：Biomaterials

authors： Cho YW,Park SA,Han TH,Son DH,Park JS,Oh SJ,Moon DH,Cho KJ,Ahn CH,Byun Y,Kim IS,Kwon IC,Kim SY

更新日期：2007-02-01 00:00:00

abstract：:We compared the osteogenic response in porous alumni (Al) and hydroxyapatite coated porous alumni ceramic (HA/Al) by grafting rat bone marrow cells with these implants subcutaneously in the back of syngeneic rats. The ceramics did not show any bone formation without marrow, but did when combined with marrow cells. The...

journal_title：Biomaterials

authors： Takaoka T,Okumura M,Ohgushi H,Inoue K,Takakura Y,Tamai S

更新日期：1996-08-01 00:00:00

abstract：UNLABELLED:Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir fo...

journal_title：Biomaterials

authors： Rafat M,Xeroudaki M,Koulikovska M,Sherrell P,Groth F,Fagerholm P,Lagali N

更新日期：2016-03-01 00:00:00