Abstract:
:A number of phase separation pHEMA sponge hydrogels have been prepared based on variations in monomer contents, concentration of cross-linking agent, solvent mixture and temperature of polymerization. The loading levels and release profiles of the anti-inflammatory drug prednisolone were examined for each of the pHEMA sponge materials. An effective diffusion coefficient determined by an optimization approach based on the experimental data was used to measure their release characteristics. The effect of morphological variations, revealed by the environmental scanning electron microscopy, and polymer/solvent volume fractions on these properties were discussed.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Lou X,Munro S,Wang Sdoi
10.1016/j.biomaterials.2004.01.058keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
5071-80issue
20eissn
0142-9612issn
1878-5905pii
S0142961204001140journal_volume
25pub_type
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