Abstract：
:Gold nanoparticles have received a great deal of interest due to their unique optical and catalytic properties and biomedical applications. Developing applications as well as assessing associated risks requires an understanding of the interactions between Au nanoparticles (NPs) and biologically active substances. In this paper, electron spin resonance spectroscopy (ESR) was used to investigate the catalytic activity of Au NPs in biologically relevant reactions. We report here that Au NPs can catalyze the rapid decomposition of hydrogen peroxide. Decomposition of hydrogen peroxide is accompanied by the formation of hydroxyl radicals at lower pH and oxygen at higher pH. In addition, we found that, mimicking SOD, Au NPs efficiently catalyze the decomposition of superoxide. These results demonstrate that Au NPs can act as SOD and catalase mimetics. Since reactive oxygen species are biologically relevant products being continuously generated in cells, these results obtained under conditions resembling different biological microenvironments may provide insights for evaluating risks associated with Au NPs.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
He W,Zhou YT,Wamer WG,Hu X,Wu X,Zheng Z,Boudreau MD,Yin JJdoi
10.1016/j.biomaterials.2012.10.010subject
Has Abstractpub_date
2013-01-01 00:00:00pages
765-73issue
3eissn
0142-9612issn
1878-5905pii
S0142-9612(12)01131-3journal_volume
34pub_type
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