A microchip filter device incorporating slit arrays and 3-D flow for detection of circulating tumor cells using CAV1-EpCAM conjugated microbeads.

abstract：:Although synergistic therapy for tumors has displayed significant promise for effective treatment of cancer, developing a simple and effective strategy to build a multi-functional nanoplatform is still a huge challenge. By virtue of the characteristics of tumor microenvironment, such as hypoxia, slight acidity and H2O...

journal_title：Biomaterials

authors： Wang M,Chang M,Chen Q,Wang D,Li C,Hou Z,Lin J,Jin D,Xing B

更新日期：2020-09-01 00:00:00

abstract：:Membranes based on mechanically supported poly(vinyl alcohol) (PVA) hydrogels with mesh-size asymmetry were developed for potential application in biohybrid artificial organs. The pores of cellulose ester microfiltration membranes were impregnated with a PVA solution, which was lightly crosslinked with glutaraldehyde ...

journal_title：Biomaterials

authors： Dai WS,Barbari TA

更新日期：2000-07-01 00:00:00

abstract：:Cell detachment by laminar shear stresses was used to characterize cellular interactions with hydrophilic glass and hydrophobic silane. In this study, we examined whether smaller, rounder cells were preferentially detached by laminar flow, and whether cell detachment occurred by dissociation of adhesion proteins and t...

journal_title：Biomaterials

authors： Truskey GA,Proulx TL

更新日期：1993-01-01 00:00:00

abstract：:The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically...

journal_title：Biomaterials

authors： Märtson M,Viljanto J,Hurme T,Laippala P,Saukko P

更新日期：1999-11-01 00:00:00

abstract：:Membranes of 75% and 100% benzyl hyaluronate esters (percentage of total carboxylate groups esterified) were prepared and their water vapour, oxygen and carbon dioxide transmission rates determined. The values of these properties were compared with the values obtained for several commercial wound dressings under the s...

journal_title：Biomaterials

authors： Ruiz-Cardona L,Sanzgiri YD,Benedetti LM,Stella VJ,Topp EM

更新日期：1996-08-01 00:00:00

abstract：:Dacron velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to ...

journal_title：Biomaterials

authors： Paquay YC,de Ruijter JE,van der Waerden JP,Jansen JA

更新日期：1996-06-01 00:00:00

abstract：:The hydrophilic nature of hydrogel matrices makes them disadvantageous to entrap poorly soluble therapeutic agents and greatly restricts their applications as drug-delivery systems. In this study, we demonstrated that sustained delivery of lipophilic drugs in hydrogel-based devices can be readily achieved by enhancing...

journal_title：Biomaterials

authors： Chen MC,Tsai HW,Liu CT,Peng SF,Lai WY,Chen SJ,Chang Y,Sung HW

更新日期：2009-04-01 00:00:00

abstract：:We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost constant. Our observations rev...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Yamane S,Hashimoto M,Takatori Y,Ishihara K

更新日期：2013-10-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, ...

journal_title：Biomaterials

authors： Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

更新日期：2012-01-01 00:00:00

abstract：:To evaluate whether cytokeratin expression in human oral epithelial cells could be influenced by implant materials used in dental surgery, passaged human oral gingival epithelial cells were seeded on commercially pure titanium (CP-Ti) or on Ti6Al4V titanium alloy. Confluence was achieved after about 15 days on both su...

journal_title：Biomaterials

authors： Lagneau C,Farges JC,Exbrayat P,Lissac M

更新日期：1998-06-01 00:00:00

abstract：:Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined gene/photothermal ...

journal_title：Biomaterials

authors： Tang J,Li B,Howard CB,Mahler SM,Thurecht KJ,Wu Y,Huang L,Xu ZP

更新日期：2019-09-01 00:00:00

abstract：:Inorganic phosphate (Pi) is a physiological regulator of osteoblasts and chondrocytes, suggesting that phosphate may contribute to the biological response of these cells to bioactive glasses like Bioglass 45S5, which is composed of 45% SiO2, 24.5% CaO, 24.5% Na2O, and 6% P2O5. We investigated the effect of varying the...

journal_title：Biomaterials

authors： Lossdörfer S,Schwartz Z,Lohmann CH,Greenspan DC,Ranly DM,Boyan BD

更新日期：2004-06-01 00:00:00

abstract：:Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth factor is known to enhance chondrocyte differentiation and endochondral ossification during development, yet whether PGRN also plays a role in bone regeneration remains un...

journal_title：Biomaterials

authors： Zhao YP,Tian QY,Frenkel S,Liu CJ

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this research was to develop porous poly(D,L-lactide-co-glycolide) (PLGA) scaffolds from which ascorbate-2-phosphate (AsAP) and dexamethasone (Dex) are continuously released for a month for osteogenesis of mesenchymal stem cells for bone tissue engineering. Porous PLGA matrices containing AsAP and Dex w...

journal_title：Biomaterials

authors： Kim H,Kim HW,Suh H

更新日期：2003-11-01 00:00:00

abstract：:Thermosensitive "micellar hydrogel" is prepared based on poly(ε-caprolactone-co- 1,4,8-trioxa[4.6]spiro-9-undecanone)-b-poly(ethylene glycol)- b-poly(ε-caprolactone- co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) triblock copolymer. Fluorescence resonance energy transfer (FRET) is adopted to explore its assembly (form...

journal_title：Biomaterials

authors： Huang P,Song H,Zhang Y,Liu J,Cheng Z,Liang XJ,Wang W,Kong D,Liu J

更新日期：2017-11-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:We have used a new synthetic injectable composite constituted of hydroxyapatite/tricalcium phosphate (HA/TCP) particles in suspension in a self-hardening Si-hydroxypropylmethylcellulose (HPMC) hydrogel. The aim of this study was to evaluate in vivo the biocompatibility and the new bone formation efficacy of this scaff...

journal_title：Biomaterials

authors： Trojani C,Boukhechba F,Scimeca JC,Vandenbos F,Michiels JF,Daculsi G,Boileau P,Weiss P,Carle GF,Rochet N

更新日期：2006-06-01 00:00:00

abstract：:A novel class of multiblock poly(epsilon-caprolactone)-based polymers containing hydrophilic trioxyethylene segments and potentially relevant to the delivery of drugs is described in this work. L-phenylalanine residues may also be inserted into the hydrophilic blocks to generate peptide bonds susceptible to enzymatic ...

journal_title：Biomaterials

authors： Barbato F,La Rotonda MI,Maglio G,Palumbo R,Quaglia F

更新日期：2001-06-01 00:00:00

abstract：:Human cell therapy applications in tissue engineering, such as the ex vivo production of hematopoietic cells for transplantation, have recently entered the clinic. Although considerable effort has been focused on the development of biological processes to generate therapeutic cells, little has been published on the de...

journal_title：Biomaterials

authors： Koller MR,Palsson MA,Manchel I,Maher RJ,Palsson BO

更新日期：1998-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic/stromal reaction, which contributes to the poor clinical outcome of this disease. Therefore, greater understanding of the stroma development and tumor-stroma interactions is highly required. Pancreatic stellate cells (PSC) are myofibr...

journal_title：Biomaterials

authors： Ware MJ,Keshishian V,Law JJ,Ho JC,Favela CA,Rees P,Smith B,Mohammad S,Hwang RF,Rajapakshe K,Coarfa C,Huang S,Edwards DP,Corr SJ,Godin B,Curley SA

更新日期：2016-11-01 00:00:00

abstract：:Bioactive glasses are potentially useful as bone defect fillers, and vascular endothelial growth factor (VEGF) has demonstrated benefit in bone regeneration as well. We hypothesized that the specific combination of prolonged localized VEGF presentation from a matrix coated with a bioactive glass may enhance bone regen...

journal_title：Biomaterials

authors： Leach JK,Kaigler D,Wang Z,Krebsbach PH,Mooney DJ

更新日期：2006-06-01 00:00:00

abstract：:Helicobacter pylori is a significant human pathogen that recognizes specific carbohydrate receptors, such as the fucose receptor, and produces the vacuolating cytotoxin, which induces inflammatory responses and modulates the cell-cell junction integrity of the gastric epithelium. The clinical applicability of topical ...

journal_title：Biomaterials

authors： Lin YH,Tsai SC,Lai CH,Lee CH,He ZS,Tseng GC

更新日期：2013-06-01 00:00:00

abstract：:Methyl methacrylate (MMA) is a volatile liquid widely used in the manufacture of acrylic polymers. In modern dentistry, MMA is the mainstream material in denture bases. MMA has been implicated as primary irritant and sensitizer, which can cause allergic eczematous reaction on the oral mucosa as well as skin. To date, ...

journal_title：Biomaterials

authors： Yang HW,Chou LS,Chou MY,Chang YC

更新日期：2003-08-01 00:00:00

abstract：:Reverse phase protein microarrays (RPMA) enable high throughput screening of posttranslational modifications of important signaling proteins within diseased cells. One limitation of protein-based molecular profiling is the lack of a PCR-like intrinsic amplification system for proteins. Enhancement of protein microarra...

journal_title：Biomaterials

authors： Nijdam AJ,Ming-Cheng Cheng M,Geho DH,Fedele R,Herrmann P,Killian K,Espina V,Petricoin EF 3rd,Liotta LA,Ferrari M

更新日期：2007-01-01 00:00:00

abstract：:Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stab...

journal_title：Biomaterials

authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoit JP

更新日期：2003-10-01 00:00:00

abstract：:Retinal pigment epithelial (RPE) cellular morphology and function are vital to the health of the retina. In age-related macular degeneration, RPE dysfunction and changes in Bruch's membrane occur. Thus, a potential cure is a dual-layer biomimetic transplant consisting of a layer of healthy RPE cells cultured on a supp...

journal_title：Biomaterials

authors： Lee CJ,Fishman HA,Bent SF

更新日期：2007-04-01 00:00:00

abstract：:Biodegradable and pH-sensitive hydrogels containing azoaromatic moieties were synthesized from the same polymeric precursors by two synthetic methods, namely a polymer-polymer reaction and cross-linking of polymeric precursors. The effect of the synthetic route employed and the detailed network structure on in vitro d...

journal_title：Biomaterials

authors： Ghandehari H,Kopecková P,Kopecek J

更新日期：1997-06-01 00:00:00

abstract：:Because of the ability to induce cell death in certain conditions, the fullerenes (C(60)) are potential anticancer and toxic agents. The colloidal suspension of crystalline C(60) (nano-C(60), nC(60)) is extremely toxic, but the mechanisms of its cytotoxicity are not completely understood. By combining experimental ana...

journal_title：Biomaterials

authors： Markovic Z,Todorovic-Markovic B,Kleut D,Nikolic N,Vranjes-Djuric S,Misirkic M,Vucicevic L,Janjetovic K,Isakovic A,Harhaji L,Babic-Stojic B,Dramicanin M,Trajkovic V

更新日期：2007-12-01 00:00:00

abstract：:Surface plasmon resonance (SPR) sensing has long been used to study biomolecular binding events and their kinetics in a label-free way. This approach has recently been extended to SPR microscopy, which is an ideal tool for probing large microarrays of biomolecules for their binding interactions with various partners a...

journal_title：Biomaterials

authors： Campbell CT,Kim G

更新日期：2007-05-01 00:00:00

abstract：:Dextran derivatives are biosynthetic polyanionic polymers which exert some of the heparin properties such as regulating the activity of several heparin-binding growth factors. Based on a reproducible synthetic procedure, we have synthesized a new generation of dextran derivatives named dextran methylcarboxylate benzyl...

journal_title：Biomaterials

authors： Vercoutter-Edouart AS,Dubreucq G,Vanhoecke B,Rigaut C,Renaux F,Dahri-Correia L,Lemoine J,Bracke M,Michalski JC,Correia J

更新日期：2008-05-01 00:00:00