Guinea pig and rabbit model for the histological evaluation of permanent percutaneous implants.

abstract：:Drug carrier particles composed of poly(ethylene glycol)-co-poly(sebacic acid) (PEG-PSA) have been shown capable of efficient aerosolization into model lungs and the ability to rapidly penetrate human mucus. Here, we develop PEG-PSA particles (Etop/PEG-PSA) that encapsulate up to 40% etoposide by weight in a one step ...

journal_title：Biomaterials

authors： Tang BC,Fu J,Watkins DN,Hanes J

更新日期：2010-01-01 00:00:00

abstract：:The clinical usefulness of brain machine interfaces that employ penetrating silicon microelectrode arrays is limited by inconsistent performance at chronic time points. While it is widely believed that elements of the foreign body response (FBR) contribute to inconsistent single unit recording performance, the relatio...

journal_title：Biomaterials

authors： Nolta NF,Christensen MB,Crane PD,Skousen JL,Tresco PA

更新日期：2015-01-01 00:00:00

abstract：:We hypothesized that reduced stem stiffness of orthopaedic implants contributes to a high risk of loosening, since interface stresses and relative motions may exceed a tolerable range. To study this hypothesis, three types of load-bearing implant with different stiffnesses were inserted into the tibia of the goat. His...

journal_title：Biomaterials

authors： Buma P,van Loon PJ,Versleyen H,Weinans H,Slooff TJ,de Groot K,Huiskes R

更新日期：1997-09-01 00:00:00

abstract：:Boiling diluted alkali incubation was found to be an effective way to prepare bioactive Ti6Al4V surfaces, whether polished or not, as indicated in vitro after immersion in two different supersaturated calcification solutions (SCSs). The induction of calcium phosphate (Ca-P) precipitation from the SCSs is most probably...

journal_title：Biomaterials

authors： Wen HB,de Wijn JR,Cui FZ,de Groot K

更新日期：1998-01-01 00:00:00

abstract：:Chlorin-core star-shaped block copolymer (CSBC) may self-assemble to form micelles, which act as nanosized photosensitizing agents for photodynamic therapy (PDT) and further encapsulate hydrophobic drugs. This functionalized micellar delivery system is a potential dual carrier for the synergistic combination of photod...

journal_title：Biomaterials

authors： Peng CL,Lai PS,Lin FH,Yueh-Hsiu Wu S,Shieh MJ

更新日期：2009-07-01 00:00:00

abstract：:Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts o...

journal_title：Biomaterials

authors： Nguyen KT,West JL

更新日期：2002-11-01 00:00:00

abstract：:The fracture toughness of three polymethacrylate contact lens hydrogel materials was measured using the method of Generalized Fracture Mechanics. One hydrogel (SNOFLEX S68) had a significantly higher fracture energy per unit area (Jc) than the others, probably because it undergoes plastic deformation at high strains. ...

journal_title：Biomaterials

authors： Jackson AP

更新日期：1990-08-01 00:00:00

abstract：:A novel biodegradable polymer blend was developed for potential biomedical applications. A 50:50 poly(lactide-co-glycolide) (PLAGA) was blended in a 50:50 ratio with the followiing polyphosphazenes (PPHOS): poly[(25% ethyl glycinato)(75% p-methylphenoxy)phosphazene[, poly[(50% ethyl glycinato)(50% p-methylphenoxy)phos...

journal_title：Biomaterials

authors： Ibim SE,Ambrosio AM,Kwon MS,El-Amin SF,Allcock HR,Laurencin CT

更新日期：1997-12-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:Micropipette aspiration (MA) has been used extensively in biomechanical investigations of un-adhered cells suspended in media. In the current study, a custom MA system is developed to aspirate substrate adhered spread cells. Additionally, the system facilitates immuno-fluorescent staining of aspirated cells to investi...

journal_title：Biomaterials

authors： Reynolds NH,Ronan W,Dowling EP,Owens P,McMeeking RM,McGarry JP

更新日期：2014-04-01 00:00:00

abstract：:A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin su...

journal_title：Biomaterials

authors： Mi FL,Shyu SS,Wu YB,Lee ST,Shyong JY,Huang RN

更新日期：2001-01-01 00:00:00

abstract：:The in vivo cellular microenvironment is regulated by a complex interplay of soluble factors and signaling molecules secreted by cells and it plays a critical role in the growth and development of normal and diseased tissues. In vitro systems that can recapitulate the microenvironment at the cellular level are needed ...

journal_title：Biomaterials

authors： Chandrasekaran S,Giang UB,King MR,DeLouise LA

更新日期：2011-10-01 00:00:00

abstract：:Nanomaterials conjugated with biomacromolecules, including viruses, have great potential for in vivo applications. Therefore, it is important to evaluate the safety of nanoparticle-conjugated macromolecule biomaterials (Nano-mbio). Although a number of studies have assessed the risks of nanoparticles and macromolecule...

journal_title：Biomaterials

authors： Wang M,Zheng Z,Meng J,Wang H,He M,Zhang F,Liu Y,Hu B,He Z,Hu Q,Wang H

更新日期：2015-09-01 00:00:00

abstract：:Great efforts have been made to develop suitable bioactive constructs that release growth factors (GFs) in a controlled manner for tissue-regeneration applications. Platelet lysates (PLs) are an affordable source of multiple GFs and other proteins, and show great potential in the wound-healing process. Herein, poly-l-...

journal_title：Biomaterials

authors： Tang Q,Lim T,Wei XJ,Wang QY,Xu JC,Shen LY,Zhu ZZ,Zhang CQ

更新日期：2020-10-01 00:00:00

abstract：:In this work, analytical transmission electron microscopy (TEM) was used to study the nanostructure of mineralised ivory dentine, in order to gain a clearer understanding of the relationship between the organic (collagen fibrils) and inorganic (calcium phosphate apatite crystals) components. Thin sections prepared by ...

journal_title：Biomaterials

authors： Jantou-Morris V,Horton MA,McComb DW

更新日期：2010-07-01 00:00:00

abstract：:Scaffolds derived from naturally occurring extracellular matrix (ECM) have found extensive use in the fields of tissue engineering and regenerative medicine. Many of these scaffolds are designed to degrade rapidly as they are replaced by new host tissue. Other scaffolds are chemically crosslinked to slow the rate of d...

journal_title：Biomaterials

authors： Gilbert TW,Stewart-Akers AM,Badylak SF

更新日期：2007-01-01 00:00:00

abstract：:Hydrogel materials that display inherent activity against bacteria can be used to directly treat accessible wounds to prevent or kill existing infection. Hydrogels composed of self-assembling β-hairpin peptides, having a high content of arginine, were found to be extremely effective at killing both gram-positive and g...

journal_title：Biomaterials

authors： Veiga AS,Sinthuvanich C,Gaspar D,Franquelim HG,Castanho MA,Schneider JP

更新日期：2012-12-01 00:00:00

abstract：:Native extracellular matrix (ECM) that is secreted and maintained by resident cells is of great interest for cell culture and cell delivery. We hypothesized that specialized bioengineered niches for stem cells can be established using ECM-derived scaffolding materials. Kidney was selected as a model system because of ...

journal_title：Biomaterials

authors： O'Neill JD,Freytes DO,Anandappa AJ,Oliver JA,Vunjak-Novakovic GV

更新日期：2013-12-01 00:00:00

abstract：:Inspired by nature's toughening mechanisms, we designed a new polyhedral oligomeric silsesquioxane (POSS)-derived hybrid glass (PHG) that has covalent interactions on the molecular scale between the inorganic POSS cage and organic phase. These features allow "elastic deformation" of the inorganic POSS cage in limited ...

journal_title：Biomaterials

authors： Zhou X,Sahai N,Qi L,Mankoci S,Zhao W

更新日期：2015-05-01 00:00:00

abstract：:The currently available surgical options to repair the diaphragm are associated with significant risks of defect recurrence, lack of growth potential and restored functionality. A tissue engineered diaphragm has the potential to improve surgical outcomes for patients with congenital or acquired disorders. Here we show...

journal_title：Biomaterials

authors： Gubareva EA,Sjöqvist S,Gilevich IV,Sotnichenko AS,Kuevda EV,Lim ML,Feliu N,Lemon G,Danilenko KA,Nakokhov RZ,Gumenyuk IS,Grigoriev TE,Krasheninnikov SV,Pokhotko AG,Basov AA,Dzhimak SS,Gustafsson Y,Bautista G,Beltrán Ro

更新日期：2016-01-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:Cancer cell metabolism is quite different from normal cells. Targeting cancer metabolism and untuning the tumor metabolic machine has emerged as a promising strategy for cancer therapy. We have developed a multi-functional Re-dca conjugate (Re-dca 2) by conjugating the metabolic modulator dichloroacetate (DCA) to mito...

journal_title：Biomaterials

authors： Yang J,Cao Q,Zhang H,Hao L,Zhou D,Gan Z,Li Z,Tong YX,Ji LN,Mao ZW

更新日期：2018-09-01 00:00:00

abstract：:Poly(trimethylene carbonate) (PTMC) with molecular weights greater than 100 kg/mol is known to degrade readily in vivo while PTMC of less than 70 kg/mol is resistant to degradation. The reason for the molecular weight dependent degradation rate of PTMC is unclear, and may be due to differences in macrophage behavior o...

journal_title：Biomaterials

authors： Vyner MC,Li A,Amsden BG

更新日期：2014-11-01 00:00:00

abstract：:Three proprietary dental resins were found to include acrylates (as distinct from methacrylates). As acrylates are well known to have adverse skin reactions, the nature and content of the acrylates were obtained. One resin contained methyl acrylate, and the other two ethyl acrylate. Also, the extractable free monomer ...

journal_title：Biomaterials

authors： Davy KW,Braden M

更新日期：1991-08-01 00:00:00

abstract：:The recent introduction of microseparation of the components of ceramic-on-ceramic hip prostheses during hip simulations has produced clinically relevant wear rates, wear patterns and wear particles. This provided an opportunity to determine the response of primary human peripheral blood mononuclear cells to clinicall...

journal_title：Biomaterials

authors： Hatton A,Nevelos JE,Matthews JB,Fisher J,Ingham E

更新日期：2003-03-01 00:00:00

abstract：:Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-link...

journal_title：Biomaterials

authors： Vizárová K,Bakos D,Rehákova M,Petríkova M,Panáková E,Koller J

更新日期：1995-11-01 00:00:00

abstract：:Besides as an inert carrier for hydrophobic anticancer agents, polymeric micelles composed of di-block copolymer poly(ethylene glycol)-poly(lactic acid) (PEG-b-PLA) function as biological response modifiers including reversal of multidrug resistance in cancer. However, the uptake mechanisms and the subsequent intracel...

journal_title：Biomaterials

authors： Zhang Z,Xiong X,Wan J,Xiao L,Gan L,Feng Y,Xu H,Yang X

更新日期：2012-10-01 00:00:00

abstract：:Multiwalled carbon nanotubes (MWCNTs) are cut short and grafted with polyethylenimine (PEI) for further covalent conjugation to fluorescein isothiocyanate (FITC) and prostate stem cell antigen (PSCA) monoclonal antibody (mAb). The in vitro and in vivo toxicity data reveal that the as-prepared CNT-PEI(FITC)-mAb has goo...

journal_title：Biomaterials

authors： Wu H,Shi H,Zhang H,Wang X,Yang Y,Yu C,Hao C,Du J,Hu H,Yang S

更新日期：2014-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) induced hypoxia can significantly upregulate the expression of vascular endothelial growth factor (VEGF) at the tumor-stromal interface, resulting in a promoted angiogenesis. Thus, an angiogenesis vessel-targeting nanoparticle (AVT-NP) consisting of photosensitizer, angiogenic vessel-targeti...

journal_title：Biomaterials

authors： Guo D,Xu S,Wang N,Jiang H,Huang Y,Jin X,Xue B,Zhang C,Zhu X

更新日期：2017-11-01 00:00:00

abstract：:There is extensive experimental and surgical experience with the use of bone tissue to fill defects in the skeleton, to bridge non-union sites, and to pack defects in bone created from cyst curettage. DP-bioactive glass with a chemical composition of Na2O 8.4%, SiO2 39.6%, P2O5 12% and CaO 40% has been reported as an ...

journal_title：Biomaterials

authors： Lin FH,Lin CC,Liu HC,Huang YY,Wang CY,Lu CM

更新日期：1994-10-01 00:00:00