Abstract：
:A novel asymmetric chitosan membrane has been prepared by immersion-precipitation phase-inversion method and evaluated as wound covering. This new type of chitosan wound dressing which consists of skin surface on top-layer supported by a macroporous sponge-like sublayer was designed. The thickness of the dense skin surface and porosity of sponge-like sublayer could be controlled by the modification of phase-separation process using per-evaporation method. The asymmetric chitosan membrane showed controlled evaporative water loss, excellent oxygen permeability and promoted fluid drainage ability but could inhibit exogenous microorganisms invasion due to the dense skin layer and inherent antimicrobial property of chitosan. Wound covered with the asymmetric chitosan membrane was hemostatic and healed quickly. Histological examination confirmed that epithelialization rate was increased and the deposition of collagen in the dermis was well organized by covering the wound with this asymmetric chitosan membrane. The results in this study indicate that the asymmetric chitosan membrane thus prepared could be adequately employed in the future as a wound dressing.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Mi FL,Shyu SS,Wu YB,Lee ST,Shyong JY,Huang RNdoi
10.1016/s0142-9612(00)00167-8keywords:
subject
Has Abstractpub_date
2001-01-01 00:00:00pages
165-73issue
2eissn
0142-9612issn
1878-5905pii
S0142-9612(00)00167-8journal_volume
22pub_type
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