当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.

A free-standing multilayer film as a novel delivery carrier of platelet lysates for potential wound-dressing applications.

Abstract：

:Great efforts have been made to develop suitable bioactive constructs that release growth factors (GFs) in a controlled manner for tissue-regeneration applications. Platelet lysates (PLs) are an affordable source of multiple GFs and other proteins, and show great potential in the wound-healing process. Herein, poly-l-lysine (PLL) and hyaluronic acid (HA) were applied to build free-standing polyelectrolyte multilayer films (PEMs) using the PH-amplified layer-by-layer self-assembly method. Molecular simulations were performed, which showed that in the end layer of PEMs, HA was more attractive to PLs than was PLL. The HA/PLL films constructed with or without 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) cross-linking both absorbed PLs successfully, exhibiting high hydrophilicity and GF absorptivity. The release profile of the EDC30 film lasted up to 2 weeks, and PL-loaded films supported cell proliferation, adhesion, migration, and angiogenesis in vitro. Moreover, due to sustained delivery of PLs, the membranes (especially the crosslinked film) helped to promote granulation-tissue formation, collagen deposition, and neovascularization in the region of the defect, resulting in rapid re-epithelialization and regeneration of skin. Mechanistically, the beneficial effects of a PL-loaded PEM coating might be related to activation of the hypoxia-inducible factor-1(Hif-1α)/vascular endothelial growth factor (VEGF) axis. As an off-the-shelf and cell-free treatment option, these biomimetic multilayers have great potential for use in the fabrication of devices that allow stable incorporation of PLs, thereby exerting synergistic effects for efficient wound healing.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Tang Q,Lim T,Wei XJ,Wang QY,Xu JC,Shen LY,Zhu ZZ,Zhang CQ

doi

10.1016/j.biomaterials.2020.120138

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

120138

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(20)30384-7

journal_volume

255

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • The effect of cerium valence states at cerium oxide nanoparticle surfaces on cell proliferation.

    abstract：:Understanding and controlling cell proliferation on biomaterial surfaces is critical for scaffold/artificial-niche design in tissue engineering. The mechanism by which underlying integrin ligates with functionalized biomaterials to induce cell proliferation is still not completely understood. In this study, poly-l-lac...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.01.074

    authors： Naganuma T,Traversa E

    更新日期：2014-05-01 00:00:00

  • Surface modification of electrospun fibres for biomedical applications: A focus on radical polymerization methods.

    abstract：:The development of electrospun ultrafine fibres from biodegradable and biocompatible polymers has created exciting opportunities for biomedical applications. Fibre meshes with high surface area, suitable porosity and stiffness have been produced. Despite desirable structural and topographical properties, for most synt...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2016.08.011

    authors： Duque Sánchez L,Brack N,Postma A,Pigram PJ,Meagher L

    更新日期：2016-11-01 00:00:00

  • Neutrophil polarization and immunoelectrophoresis assays in the study of complement activation by biomaterials.

    abstract：:The neutrophil polarization assay, a technique used to measure chemotaxis, was adapted to examine complement activation. Complement activation in serum which had been incubated with metallic and polymeric biomaterials was examined using the neutrophil polarization assay and immunoelectrophoresis assay. In agreement wi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(91)90060-n

    authors： Remes A,Williams DF

    更新日期：1991-08-01 00:00:00

  • Metabolic glycan labeling and chemoselective functionalization of native biomaterials.

    abstract：:Decellularized native extracellular matrix (ECM) biomaterials are widely used in tissue engineering and have reached clinical application as biomesh implants. To enhance their regenerative properties and postimplantation performance, ECM biomaterials could be functionalized via immobilization of bioactive molecules. T...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.08.012

    authors： Ren X,Evangelista-Leite D,Wu T,Rajab TK,Moser PT,Kitano K,Economopoulos KP,Gorman DE,Bloom JP,Tan JJ,Gilpin SE,Zhou H,Mathisen DJ,Ott HC

    更新日期：2018-11-01 00:00:00

  • Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells.

    abstract：:Fibronectin (Fn) forms a fibrillar network that controls cell behavior in both physiological and diseased conditions including cancer. Indeed, breast cancer-associated stromal cells not only increase the quantity of deposited Fn but also modify its conformation. However, (i) the interplay between mechanical and confor...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.03.019

    authors： Wang K,Andresen Eguiluz RC,Wu F,Seo BR,Fischbach C,Gourdon D

    更新日期：2015-06-01 00:00:00

  • Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications.

    abstract：:Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2019.119706

    authors： Cheng R,Liu L,Xiang Y,Lu Y,Deng L,Zhang H,Santos HA,Cui W

    更新日期：2020-02-01 00:00:00

  • Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models.

    abstract：:An increasing number of treatments of metastases rely on diagnostics and imaging these days. The facts that the activity of cathepsin B (CB) is markedly linked to the metastatic process and that CB is found highly expressed in the pericellular regions in this process make CB an attractive target for diagnosing metasta...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.11.080

    authors： Ryu JH,Na JH,Ko HK,You DG,Park S,Jun E,Yeom HJ,Seo DH,Park JH,Jeong SY,Kim IS,Kim BS,Kwon IC,Choi K,Kim K

    更新日期：2014-02-01 00:00:00

  • Adsorption of amphiphilic hyperbranched polyglycerol derivatives onto human red blood cells.

    abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.01.021

    authors： Liu Z,Janzen J,Brooks DE

    更新日期：2010-04-01 00:00:00

  • Gel-impregnated pore membranes with mesh-size asymmetry for biohybrid artificial organs.

    abstract：:Membranes based on mechanically supported poly(vinyl alcohol) (PVA) hydrogels with mesh-size asymmetry were developed for potential application in biohybrid artificial organs. The pores of cellulose ester microfiltration membranes were impregnated with a PVA solution, which was lightly crosslinked with glutaraldehyde ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00022-3

    authors： Dai WS,Barbari TA

    更新日期：2000-07-01 00:00:00

  • Chemical and physical properties of a hydrogel wound dressing.

    abstract：:Geliperm hydrogel provides optimal physiological conditions for wound healing. The material is composed of two interlaced networks, one of polyacrylamide and one of agar, and contains about 96% firmly bound water. It is supplied in smooth, elastic, transparent sheets which are impermeable to bacteria but permeable to ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(86)90092-x

    authors： Kickhöfen B,Wokalek H,Scheel D,Ruh H

    更新日期：1986-01-01 00:00:00

  • Influence of soluble suture factors on in vitro macrophage function.

    abstract：:Suture materials may interact with immune competent cells and thereby affect localized immunity. Macrophages are central to the inflammatory response and coordinate wound healing. They are also involved in the clearance of foreign material, bacteria and malignant cells. We studied the influence of soluble factors asso...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(95)93852-5

    authors： Uff CR,Scott AD,Pockley AG,Phillips RK

    更新日期：1995-03-01 00:00:00

  • In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-based hydrogels.

    abstract：:In this in vitro study, the biocompatibility of acrylamide-based hydrogels such as acrylamide/crotonic and acrylamide/itaconic acid, prepared by using gamma-rays, has been investigated against some biochemical parameters of human serum. The swelling kinetics of acrylamide/crotonic and acrylamide/itaconic acid hydrogel...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)80757-5

    authors： Karadağ E,Saraydin D,Cetinkaya S,Güven O

    更新日期：1996-01-01 00:00:00

  • Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA.

    abstract：:A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using these pol...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.06.021

    authors： Kainthan RK,Gnanamani M,Ganguli M,Ghosh T,Brooks DE,Maiti S,Kizhakkedathu JN

    更新日期：2006-11-01 00:00:00

  • Recombinant spider silk matrices for neural stem cell cultures.

    abstract：:Neural stem cells (NSCs) have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes. Accordingly, NSCs hold great promise in drug screening and treatment of several common diseases. However, a major obstacle in applied stem cell research is the limitation of synthetic matrices for culturing stem...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.07.021

    authors： Lewicka M,Hermanson O,Rising AU

    更新日期：2012-11-01 00:00:00

  • A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo.

    abstract：:B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal cen...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.02.039

    authors： Roh KH,Song HW,Pradhan P,Bai K,Bohannon CD,Dale G,Leleux J,Jacob J,Roy K

    更新日期：2018-05-01 00:00:00

  • Controlled degradation of hydrogels using multi-functional cross-linking molecules.

    abstract：:Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have hypothesized that utilization...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.09.030

    authors： Lee KY,Bouhadir KH,Mooney DJ

    更新日期：2004-06-01 00:00:00

  • In vivo measurement of anodic polarization of orthopaedic implant alloys: comparative study of in vivo and in vitro experiments.

    abstract：:A new system of single piece electrodes was applied to in vivo and in vitro measurements of anodic polarization of several alloys used in orthopaedic implants. The tested surface was scrutinized with a stereomicroscope after each experiment. This confirmed pit formation and excluded the possibility of other sudden inc...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(89)90134-8

    authors： Nakayama Y,Yamamuro T,Kotoura Y,Oka M

    更新日期：1989-08-01 00:00:00

  • A porous tissue engineering scaffold selectively degraded by cell-generated reactive oxygen species.

    abstract：:Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic breakdown products that trigger an accelerated, autocatalytic degradation mechanism that can create mismatched rates of biomateria...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.01.026

    authors： Martin JR,Gupta MK,Page JM,Yu F,Davidson JM,Guelcher SA,Duvall CL

    更新日期：2014-04-01 00:00:00

  • In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3).

    abstract：:Elimination of leukemia stem cells (LSCs) is necessary for the destruction of malignant cell populations. Owing to the very small number of LSCs in leukemia cells, xenotransplantation studies are difficult in terms of functionally and pathophysiologically replicating clinical conditions of cell culture experiments. Th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.02.009

    authors： Zhang B,Shimada Y,Kuroyanagi J,Ariyoshi M,Nomoto T,Shintou T,Umemoto N,Nishimura Y,Miyazaki T,Tanaka T

    更新日期：2015-06-01 00:00:00

  • Skeletal repair in rabbits with calcium phosphate cements incorporated phosphorylated chitin.

    abstract：:The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00205-3

    authors： Wang X,Ma J,Feng Q,Cui F

    更新日期：2002-12-01 00:00:00

  • Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth.

    abstract：:A total of 60 cylindrical 6 x 6 mm samples of a macroporous biphasic calcium phosphate (MBCP) ceramic were implanted into a distal femoral site in 30 rabbits. These samples represented six kinds of implants with two different macropore diameters and three different macroporosity percentages. Analysis of backscattered ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(97)00180-4

    authors： Gauthier O,Bouler JM,Aguado E,Pilet P,Daculsi G

    更新日期：1998-01-01 00:00:00

  • Scaffold vascularization in vivo driven by primary human osteoblasts in concert with host inflammatory cells.

    abstract：:Successful cell-based tissue engineering requires a rapid and thorough vascularization in order to ensure long-term implant survival and tissue integration. The vascularization of a scaffold is a complex process, and is modulated by the presence of transplanted cells, exogenous and endogenous signaling proteins, and t...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2011.07.041

    authors： Ghanaati S,Unger RE,Webber MJ,Barbeck M,Orth C,Kirkpatrick JA,Booms P,Motta A,Migliaresi C,Sader RA,Kirkpatrick CJ

    更新日期：2011-11-01 00:00:00

  • In vitro assessment of bacterial adhesion to Hydromer-coated cerebrospinal fluid shunts.

    abstract：:The adherence of five strains of Staphylococcus epidermidis and one strain of S. aureus to both untreated and Hydromer-coated silicone rubber cerebrospinal fluid shunts was studied in vitro using epifluorescent image analysis. All five strains of S. epidermidis showed similar levels of adherence to untreated shunts, w...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(93)90021-s

    authors： Bridgett MJ,Davies MC,Denyer SP,Eldridge PR

    更新日期：1993-02-01 00:00:00

  • The effect of micronscale anisotropic cross patterns on fibroblast migration.

    abstract：:Cell movement on adhesive surfaces is a complicated process based on myriad cell-surface interactions. Although both micron and nanoscale surface topography have been known to be important in understanding cell-materials interactions, typically only simple patterns (e.g., parallel lines or aligned posts) have been use...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.01.103

    authors： Jeon H,Hidai H,Hwang DJ,Healy KE,Grigoropoulos CP

    更新日期：2010-05-01 00:00:00

  • The in vivo degradation of a ruthenium labelled polysaccharide-based hydrogel for bone tissue engineering.

    abstract：:In this paper we report a new method that permitted for the first time to selectively track a polysaccharide-based hydrogel on bone tissue explants, several weeks after its implantation. The hydrogel, which was developed for bone healing and tissue engineering, was labelled with a ruthenium complex and implanted into ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2008.11.031

    authors： Laïb S,Fellah BH,Fatimi A,Quillard S,Vinatier C,Gauthier O,Janvier P,Petit M,Bujoli B,Bohic S,Weiss P

    更新日期：2009-03-01 00:00:00

  • Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films.

    abstract：:The objective of this study was to investigate the moisture absorption, physical-mechanical and bioadhesive properties of hot-melt extruded hydroxypropylcellulose (HPC) films containing polymer additives. These additives included polyethylene glycol (PEG) 5%, polycarbophil 5%, carbomer 5%, Eudragit E-100 5%, and sodiu...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00046-6

    authors： Repka MA,McGinity JW

    更新日期：2000-07-01 00:00:00

  • Enhancement of electrical signaling in neural networks on graphene films.

    abstract：:One of the key challenges for neural tissue engineering is to exploit supporting materials with robust functionalities not only to govern cell-specific behaviors, but also to form functional neural network. The unique electrical and mechanical properties of graphene imply it as a promising candidate for neural interfa...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.05.024

    authors： Tang M,Song Q,Li N,Jiang Z,Huang R,Cheng G

    更新日期：2013-09-01 00:00:00

  • The in vivo performance of a sol-gel glass and a glass-ceramic in the treatment of limited bone defects.

    abstract：:The in vivo evaluation, in New Zealand rabbits, of a SiO(2)-P(2)O(5)-CaO sol-gel glass and a SiO(2)-P(2)O(5)-CaO-MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5mm in diameter and 4mm in depth, wer...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.12.009

    authors： Gil-Albarova J,Garrido-Lahiguera R,Salinas AJ,Román J,Bueno-Lozano AL,Gil-Albarova R,Vallet-Regí M

    更新日期：2004-08-01 00:00:00

  • Synthesis, bioactivity and specificity of glucagon-like peptide-1 (7-37)/polymer conjugate to isolated rat islets.

    abstract：:In order to increase the functionality of islets encapsulated in a biohybrid artificial pancreas (BAP), it was proposed that co-encapsulation with insulinotropic agents would improve insulin secretion from islets. To prevent agents from leaking out, conjugation with high-molecular-weight polymers was inevitable. In th...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2004.09.045

    authors： Kim S,Wan Kim S,Bae YH

    更新日期：2005-06-01 00:00:00

  • Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with beta-cyclodextrin.

    abstract：:The aim of this study was to evaluate the physical-chemical properties, in vivo biocompatibility and antimicrobial activity of bioactive glasses (BG) used as a controlled release device for tetracycline hydrochloride and an inclusion complex formed by tetracycline and beta-cyclodextrin at 1:1 molar ratio. The BG as we...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00524-6

    authors： Domingues ZR,Cortés ME,Gomes TA,Diniz HF,Freitas CS,Gomes JB,Faria AM,Sinisterra RD

    更新日期：2004-01-01 00:00:00