The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney.

abstract：:The bulk, surface and blood-contacting properties of a series of polyether polyurethanes, modified with three different polydimethylsiloxane (PDMS) macroglycol segments, were evaluated. The PDMS oligomers were terminated with hydroxy-tipped end groups of varying polarity. The effect of substituting the polytetramethyl...

journal_title：Biomaterials

authors： Okkema AZ,Fabrizius DJ,Grasel TG,Cooper SL,Zdrahala RJ

更新日期：1989-01-01 00:00:00

abstract：:Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of culture conditions enabli...

journal_title：Biomaterials

authors： Ng CP,Sharif AR,Heath DE,Chow JW,Zhang CB,Chan-Park MB,Hammond PT,Chan JK,Griffith LG

更新日期：2014-04-01 00:00:00

abstract：:The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ(1-40) peptides under seed-mediated growth me...

journal_title：Biomaterials

authors： Chan HM,Xiao L,Yeung KM,Ho SL,Zhao D,Chan WH,Li HW

更新日期：2012-06-01 00:00:00

abstract：:To minimize the cytotoxicity of poly (2-(dimethylamino) ethyl methacrylate) (PDMAEMA) as a gene delivery vector, we synthesized PEGylated PDMAEMA by atom transfer radical polymerization (ATRP). Here we report its effects on transfection efficiency in vitro delivered with a GFP expression plasmid and immunogenicity in ...

journal_title：Biomaterials

authors： Qiao Y,Huang Y,Qiu C,Yue X,Deng L,Wan Y,Xing J,Zhang C,Yuan S,Dong A,Xu J

更新日期：2010-01-01 00:00:00

abstract：:The polymerization of N,N' carbonylbis (caprolactam) (CBC) and polyol in the presence of alcoholate as catalyst produced cross-linked poly(ester-urea)s via ring opening addition reaction. In contrast to conventional synthetic routes, the use of non-toxic CBC eliminates the need for toxic isocyanate-based monomers. The...

journal_title：Biomaterials

authors： Zimmermann J,Loontjens T,Scholtens BJ,Mülhaupt RR

更新日期：2004-06-01 00:00:00

abstract：:Copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) are prototypic and well-characterized polymeric drug carriers that have been broadly implemented in the delivery of anticancer therapeutics. To demonstrate that polymers, as liposomes, can be used for simultaneously delivering multiple chemotherapeutic agents to t...

journal_title：Biomaterials

authors： Lammers T,Subr V,Ulbrich K,Peschke P,Huber PE,Hennink WE,Storm G

更新日期：2009-07-01 00:00:00

abstract：:Here we document the complete process of bioresorption and bone replacement of rods made of forged composites of unsintered hydroxyapatite particles/poly l-lactide (F-u-HA/PLLA) implanted in the femoral medullary cavities of rabbits. Bioresorption, osteoconductive bioactivity and bone replacement were compared in thre...

journal_title：Biomaterials

authors： Shikinami Y,Matsusue Y,Nakamura T

更新日期：2005-09-01 00:00:00

abstract：:Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...

journal_title：Biomaterials

authors： Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

更新日期：2012-03-01 00:00:00

abstract：:Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for soft tissue augmentation and reconstruction. The objective of the current study was to investigate the effects of allogeneic adipose-derived stem/stromal cells (ASCs) on in vivo fat regeneration in DAT bioscaffolds using an immunoco...

journal_title：Biomaterials

authors： Han TT,Toutounji S,Amsden BG,Flynn LE

更新日期：2015-12-01 00:00:00

abstract：:Tissue engineering of clinical-relevant large tissue constructs remains a big challenge due to the mass transfer limit. A modular approach via the assembling of modular tissues thus eliminating the mass transfer limit holds great promise for fabricating centimeter-sized constructs. In the present study, we investigate...

journal_title：Biomaterials

authors： Chen M,Wang X,Ye Z,Zhang Y,Zhou Y,Tan WS

更新日期：2011-10-01 00:00:00

abstract：:Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

journal_title：Biomaterials

authors： DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

更新日期：2020-11-01 00:00:00

abstract：:The repair of spinal cord injury (SCI) highly relies on microenvironment remodeling and facilitating the recruitment and neuronal differentiation of endogenous stem/progenitor cells. Decellularized tissue matrices (DTMs) have shown their unique and beneficial characteristics in promoting neural tissue regeneration, es...

journal_title：Biomaterials

authors： Xu Y,Zhou J,Liu C,Zhang S,Gao F,Guo W,Sun X,Zhang C,Li H,Rao Z,Qiu S,Zhu Q,Liu X,Guo X,Shao Z,Bai Y,Zhang X,Quan D

更新日期：2021-01-01 00:00:00

abstract：:Quinacrine and related heterocyclic compounds have antiprion activity. Since the infectious pathogen of prion diseases is composed of multimeric PrP(Sc) assemblies, we hypothesized that this antiprion property could be enhanced by attaching multiple quinacrine-derived chloroquinoline or acridine moieties to a scaffold...

journal_title：Biomaterials

authors： Mays CE,Joy S,Li L,Yu L,Genovesi S,West FG,Westaway D

更新日期：2012-10-01 00:00:00

abstract：:Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...

journal_title：Biomaterials

authors： Rampoldi A,Jha R,Fite J,Boland G,Xu C

更新日期：2021-01-11 00:00:00

abstract：:This paper describes a method of foaming a polymer system comprising poly(ethyl methacrylate)/tetrahydrofurfuryl methacrylate (PEMA/THFMA), characterisation of the resulting porosity and use of the foam for chondrocyte culture. The potential for this polymer system to support cartilage repair has been investigated pre...

journal_title：Biomaterials

authors： Barry JJ,Gidda HS,Scotchford CA,Howdle SM

更新日期：2004-08-01 00:00:00

abstract：:RNA interference holds tremendous potential as a therapeutic approach of malignant tumors. However, safe and efficient nanovectors are extremely lack for systemic delivery of small interfering RNA (siRNA). The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targ...

journal_title：Biomaterials

authors： Ding Y,Wang W,Feng M,Wang Y,Zhou J,Ding X,Zhou X,Liu C,Wang R,Zhang Q

更新日期：2012-12-01 00:00:00

abstract：:Potential applications of engineered, functional, cardiac muscle extends from basic research through drug discovery to engineering heart tissue for transplantation. One of the central questions in cardiac tissue engineering is to understand and control the complex interactions between the cardiac muscle cells and thei...

journal_title：Biomaterials

authors： Das M,Molnar P,Gregory C,Riedel L,Jamshidi A,Hickman JJ

更新日期：2004-11-01 00:00:00

abstract：:There are many ways to influence cell activities, and biomaterials with functional groups attached is an attractive method that clearly has the ability to modulate cell behavior. The evidence is clear that biomaterials, with or without growth factors and cells, have resulted in numerous products for the regenerative m...

journal_title：Biomaterials

authors： Ratcliffe A

更新日期：2011-06-01 00:00:00

abstract：:Ischemic stroke is the leading cause of disability and death worldwide. An effective therapeutic approach is urgently needed. Stroke-induced angiogenesis and neurogenesis are essential mechanisms in the long-term repair. Extracellular matrix proteins are also involved in tissue self-repair. Recently, a PHSRN (Pro-His-...

journal_title：Biomaterials

authors： Wu CC,Wang LC,Su YT,Wei WY,Tsai KJ

更新日期：2018-12-01 00:00:00

abstract：:MicroRNAs (miRNA, miR) have been reported as cancer biomarkers that regulate tumor suppressor genes. Hence, simultaneous detecting and inhibiting of miRNA function will be useful as a cancer theragnostics probe to minimize side effects and invasiveness. In this study, we developed a cancer-targeting therangostics prob...

journal_title：Biomaterials

authors： Kim JK,Choi KJ,Lee M,Jo MH,Kim S

更新日期：2012-01-01 00:00:00

abstract：:Neural stem cells (NSCs) have the capacity to differentiate into neurons, astrocytes, and oligodendrocytes. Accordingly, NSCs hold great promise in drug screening and treatment of several common diseases. However, a major obstacle in applied stem cell research is the limitation of synthetic matrices for culturing stem...

journal_title：Biomaterials

authors： Lewicka M,Hermanson O,Rising AU

更新日期：2012-11-01 00:00:00

abstract：:The ability to manipulate and control the surface properties, without altering the substrate properties, is of crucial importance in the designing of biomedical materials. In this work, surface-initiated atom transfer radical polymerization (ATRP) is employed to tailor the functionality of polycaprolactone (PCL) film ...

journal_title：Biomaterials

authors： Xu FJ,Wang ZH,Yang WT

更新日期：2010-04-01 00:00:00

abstract：:Ectopic expression of heme oxygenase-1 (HO-1) in ischemic tissue protects the tissue from apoptosis and necrosis and promotes angiogenesis. However, apoptosis and necrosis will decrease HO-1 gene transfection efficacy. We hypothesized that fibroblast growth factor-2 (FGF2) would attenuate ischemic damage during the in...

journal_title：Biomaterials

authors： Bhang SH,Kim JH,Yang HS,La WG,Lee TJ,Sun AY,Kim GH,Lee M,Kim BS

更新日期：2009-10-01 00:00:00

abstract：:Pneumonia is a major contributor to infection-based hospitalizations and deaths in the United States. Antibiotics such as azithromycin (AZM), although effective at managing pneumonia, often suffer from off-target diffusion and poor bioavailability when administered orally or via intravenous injection. The formation of...

journal_title：Biomaterials

authors： Wang Q,Mi G,Hickey D,Li Y,Tu J,Webster TJ,Shen Y

更新日期：2018-04-01 00:00:00

abstract：:The clinical application of calcium phosphate cements (CPCs) composed of tetracalcium phosphate and dicalcium phosphate anhydrous has been limited because of its longer setting time, so that we developed the CPC in which the setting time was shortened to approximately 10 min. Aiming at clinical application, we evaluat...

journal_title：Biomaterials

authors： Hoshikawa A,Fukui N,Fukuda A,Sawamura T,Hattori M,Nakamura K,Oda H

更新日期：2003-12-01 00:00:00

abstract：:A multifunctional organic-inorganic hybrid nanocapsule based on Bi2S3-embedded poly (lactic-co-glycolic acid) (PLGA) nanocapsule has been elaborately designed to combine the merits of both polymeric shell structure and Bi2S3 nanoparticles. Hydrophobic Bi2S3 nanoparticles were successfully introduced into the PLGA nano...

journal_title：Biomaterials

authors： Yao MH,Ma M,Chen Y,Jia XQ,Xu G,Xu HX,Chen HR,Wu R

更新日期：2014-09-01 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAAm) is known to be thermally responsive material and has a lower critical solution temperature (LCST, 32 degrees C) at which a macromolecular transition from a hydrophilic to a hydrophobic structure occurs. Chitosan is a useful natural polymeric biomaterial due to its biocompatibility...

journal_title：Biomaterials

authors： Cho JH,Kim SH,Park KD,Jung MC,Yang WI,Han SW,Noh JY,Lee JW

更新日期：2004-11-01 00:00:00

abstract：:Embryonic stem (ES) cells have the ability to replicate themselves and differentiate into various mature cells. Recently, dopaminergic neurons were efficiently induced from ES cells using mouse stromal cells (PA6 cells) as a feeder cell layer. This simple procedure seems to be very efficient to obtain dopamine-releasi...

journal_title：Biomaterials

authors： Yamazoe H,Murakami Y,Mizuseki K,Sasai Y,Iwata H

更新日期：2005-10-01 00:00:00

abstract：:Two types of isoelastic endosseous dental implants were produced and their functionality was tested. One type consisted of a porous sintered TiTa30 alloy, the other had a special surface structure consisting of titanium wire loops. Their mechanical properties were optimized by the production parameter (sintering and d...

journal_title：Biomaterials

authors： Breme J,Biehl V,Schulte W,d'Hoedt B,Donath K

更新日期：1993-10-01 00:00:00

abstract：:Programmable hydrogels are defined as hydrogels that are able to change their properties and functions periodically, reversibly and/or sequentially on demand. They are different from those responsive hydrogels whose changes are passive or cannot be stopped or reversed once started and vice versa. The purpose of this r...

journal_title：Biomaterials

authors： Wang Y

更新日期：2018-09-01 00:00:00