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Surface functionalization of polycaprolactone films via surface-initiated atom transfer radical polymerization for covalently coupling cell-adhesive biomolecules.

Abstract：

:The ability to manipulate and control the surface properties, without altering the substrate properties, is of crucial importance in the designing of biomedical materials. In this work, surface-initiated atom transfer radical polymerization (ATRP) is employed to tailor the functionality of polycaprolactone (PCL) film surfaces in a well-controlled manner. Functional polymer brushes of glycidyl methacrylate (GMA) were prepared via surface-initiated ATRPs from the PCL film surfaces. Kinetics study revealed that the chain growth from the PCL films was consistent with a controlled process. The dense and reactive epoxide groups of the grafted P(GMA) brushes were used for the direct coupling of cell-adhesive collagen and Arg-Gly-Asp-Ser (RGDS) peptides to improve the cell-adhesion properties of the PCL film surface. These modified surfaces were evaluated by culturing of a cell line, 3T3 fibroblasts. The cell attachment and proliferation were improved remarkably on the collagen (or RGDS) functionalized PCL film surfaces. The adhesion results also indicated that the collagen-coupled PCL film surface is better for the cell-adhesion process. With the versatility of surface-initiated ATRP and the good biocompatibility nature of biomolecules, the PCL films with desirable surface functionalities can be precisely tailored to cater to various biomedical applications.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Xu FJ,Wang ZH,Yang WT

doi

10.1016/j.biomaterials.2010.01.032

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

3139-47

issue

12

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(10)00048-7

journal_volume

31

pub_type

杂志文章

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