Modification of layered atelocollagen: enzymatic degradation and cytotoxicity evaluation.


:Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-linked with HMDIC. This should offer the possibility of programmed enzymatic degradation. These materials may be toxicologically acceptable as proven by the short-term test used for cytotoxicity evaluation.






Vizárová K,Bakos D,Rehákova M,Petríkova M,Panáková E,Koller J




Has Abstract


1995-11-01 00:00:00














  • Computer graphics of hydroxyapatite and beta-tricalcium phosphate.

    abstract::Hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) were studied by computer graphics with a personal computer. Crystal models of fluoridated hydroxyapatite and fluorapatite, in which F- ions are substituted into some or all OH- positions, were also drawn. Data on the structural coordinates of the hydroxyapatite a...


    pub_type: 杂志文章


    authors: Okazaki M,Sato M

    更新日期:1990-10-01 00:00:00

  • The promotion of angiogenesis by growth factors integrated with ECM proteins through coiled-coil structures.

    abstract::An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...


    pub_type: 杂志文章


    authors: Assal Y,Mie M,Kobatake E

    更新日期:2013-04-01 00:00:00

  • Therapeutic potential of nanoparticulate systems for macrophage targeting.

    abstract::The use of non-viral nanoparticulate systems for the delivery of therapeutic agents is receiving considerable attention for medical and pharmaceutical applications. This increasing interest results from the fact that these systems can be designed to meet specific physicochemical requirements, and they display low toxi...


    pub_type: 杂志文章,评审


    authors: Chellat F,Merhi Y,Moreau A,Yahia L

    更新日期:2005-12-01 00:00:00

  • The performance of gadolinium diethylene triamine pentaacetate-pullulan hepatocyte-specific T1 contrast agent for MRI.

    abstract::The magnetic resonance (MR) functionalities of pullulan-conjugated gadolinium diethylene triamine pentaacetate (Gd-DTPA-Pullulan) as a new hepatocyte-specific contrast agent were evaluated. Pullulan, which specifically accumulates on hepatocytes via asialoglycoprotein receptors, was chemically linked with Gd-DTPA. Gd-...


    pub_type: 杂志文章


    authors: Yim H,Yang SG,Jeon YS,Park IS,Kim M,Lee DH,Bae YH,Na K

    更新日期:2011-08-01 00:00:00

  • AG73-modified Bubble liposomes for targeted ultrasound imaging of tumor neovasculature.

    abstract::Ultrasound imaging is a widely used imaging technique. The use of contrast agents has become an indispensible part of clinical ultrasound imaging, and molecular imaging via ultrasound has recently attracted significant attention. We recently reported that "Bubble liposomes" (BLs) encapsulating US imaging gas liposomes...


    pub_type: 杂志文章


    authors: Negishi Y,Hamano N,Tsunoda Y,Oda Y,Choijamts B,Endo-Takahashi Y,Omata D,Suzuki R,Maruyama K,Nomizu M,Emoto M,Aramaki Y

    更新日期:2013-01-01 00:00:00

  • Mechanical properties and histological evaluation of sintered beta-Ca2P2O7 with Na4P2O7.10H2O addition.

    abstract::The ultimate goal of implantation of biomaterials in the skeleton is to reach full integration of the non-living implant with the living bone. The biomaterial can be used much as a bone graft, resorbing or dissolving as bone growth occurs, and the end result is a new remoulded bone. Calcium pyrophosphate, Ca2P2O7, is ...


    pub_type: 杂志文章


    authors: Lin FH,Lin CC,Lu CM,Liu HC,Sun JS,Wang CY

    更新日期:1995-07-01 00:00:00

  • Early tumor detection afforded by in vivo imaging of near-infrared II fluorescence.

    abstract::Cell-intrinsic reporters such as luciferase (LUC) and red fluorescent protein (RFP) have been commonly utilized in preclinical studies to image tumor growth and to monitor therapeutic responses. While extrinsic reporters that emit near infrared I (NIR-I: 650-950 nm) or near-infrared II (NIR-II: 1000-1700 nm) optical s...


    pub_type: 杂志文章


    authors: Tao Z,Dang X,Huang X,Muzumdar MD,Xu ES,Bardhan NM,Song H,Qi R,Yu Y,Li T,Wei W,Wyckoff J,Birrer MJ,Belcher AM,Ghoroghchian PP

    更新日期:2017-07-01 00:00:00

  • Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices.

    abstract::Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membr...


    pub_type: 杂志文章


    authors: Weber B,Schoenauer R,Papadopulos F,Modregger P,Peter S,Stampanoni M,Mauri A,Mazza E,Gorelik J,Agarkova I,Frese L,Breymann C,Kretschmar O,Hoerstrup SP

    更新日期:2011-12-01 00:00:00

  • A three-phase, fully resorbable, polyester/calcium phosphate scaffold for bone tissue engineering: Evolution of scaffold design.

    abstract::Bone tissue engineering strategies are fundamentally based upon porous scaffold materials that serve as a support for ingrowth of host cells and/or provide a substrate for exogenously delivered cells. Here we report the application of a surface calcium phosphate (CaP) mineral layer to a macroporous polymeric/CaP compo...


    pub_type: 杂志文章


    authors: Lickorish D,Guan L,Davies JE

    更新日期:2007-03-01 00:00:00

  • MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells.

    abstract::The use of biochemical signaling to derive smooth muscle cells (SMCs) from mesenchymal stem cells (MSCs) has been explored, but the induction of a fully functional SMC phenotype remains to be a major challenge. Cell morphology has been shown to regulate MSC differentiation into various lineages, including SMCs. We eng...


    pub_type: 杂志文章


    authors: Yeh YT,Wei J,Thorossian S,Nguyen K,Hoffman C,Del Álamo JC,Serrano R,Li YJ,Wang KC,Chien S

    更新日期:2019-06-01 00:00:00

  • Optimizing the sterilization of PLGA scaffolds for use in tissue engineering.

    abstract::There are few suitable techniques available to sterilize biodegradable polyester three-dimensional tissue engineering scaffolds because they are susceptible to degradation and/or morphological degeneration by high temperature and pressure. We used a novel polyllactide-co-glycolide) scaffold (Osteofoam) to determine th...


    pub_type: 杂志文章


    authors: Holy CE,Cheng C,Davies JE,Shoichet MS

    更新日期:2001-01-01 00:00:00

  • Poly(ether-ether-ketone) orthopedic bearing surface modified by self-initiated surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine).

    abstract::We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost constant. Our observations rev...


    pub_type: 杂志文章


    authors: Kyomoto M,Moro T,Yamane S,Hashimoto M,Takatori Y,Ishihara K

    更新日期:2013-10-01 00:00:00

  • Epinecidin-1 antimicrobial activity: In vitro membrane lysis and In vivo efficacy against Helicobacter pylori infection in a mouse model.

    abstract::Helicobacter pylori (H. pylori) infection is highly prevalent, and has a strong association with various gastric diseases, including gastritis, digestive ulcers, and cancer. H. pylori strains with resistance to existing antibiotics have emerged in the past two decades. Currently, treatment of H. pylori infection (invo...


    pub_type: 杂志文章


    authors: Narayana JL,Huang HN,Wu CJ,Chen JY

    更新日期:2015-08-01 00:00:00

  • Study of water sorption, solubility and modulus of elasticity of light-cured dimethacrylate-based dental resins.

    abstract::Polydimethacrylate resins were prepared by photopolymerization of Bis-GMA, TEGDMA, UDMA or Bis-EMA (4) monomer, initiated by camphoroquinone/N,N-dimethylaminoethyl methacrylate system. The study of physical properties of these resins showed that TEGDMA seems to create the most dense polymer network, which however is t...


    pub_type: 杂志文章


    authors: Sideridou I,Tserki V,Papanastasiou G

    更新日期:2003-02-01 00:00:00

  • On the microstructure of biocomposites sintered from Ti, HA and bioactive glass.

    abstract::Sintering reactions and fine structures of the biocomposites prepared from powder mixtures of titanium ( alpha -Ti), hydroxyapatite (HA) and bioactive glass (BG) (SiO2-CaO-P2O5-B2O3-MgO-TiO2-CaF2) were investigated by X-ray diffraction and transmission electron microscopy. The results showed that complex reactions amo...


    pub_type: 杂志文章


    authors: Ning CQ,Zhou Y

    更新日期:2004-08-01 00:00:00

  • The incorporation of daunorubicin in cancer cells through the use of titanium dioxide whiskers.

    abstract::Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good bioco...


    pub_type: 杂志文章


    authors: Li Q,Wang X,Lu X,Tian H,Jiang H,Lv G,Guo D,Wu C,Chen B

    更新日期:2009-09-01 00:00:00

  • The surface properties of nanocrystalline diamond and nanoparticulate diamond powder and their suitability as cell growth support surfaces.

    abstract::Nanocrystalline diamond (NCD) films and nanoparticulate diamond powder (DP) are the two main representatives of diamond at the nanoscale. This study was designed to investigate the suitability of these biomaterials as cell growth supports and to determine surface characteristic properties best suited to cell attachmen...


    pub_type: 杂志文章


    authors: Lechleitner T,Klauser F,Seppi T,Lechner J,Jennings P,Perco P,Mayer B,Steinmüller-Nethl D,Preiner J,Hinterdorfer P,Hermann M,Bertel E,Pfaller K,Pfaller W

    更新日期:2008-11-01 00:00:00

  • Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors.

    abstract::Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for active targeting to integrin-rich cancer cells. An amphiphilic diblock copolymer, α-carboxyl poly (ethylene glycol)-poly (trimethylene carbonate) (HOOC-PEG-PTMC), was s...


    pub_type: 杂志文章


    authors: Jiang X,Sha X,Xin H,Chen L,Gao X,Wang X,Law K,Gu J,Chen Y,Jiang Y,Ren X,Ren Q,Fang X

    更新日期:2011-12-01 00:00:00

  • Synthesis of polylactides with different molecular weights.

    abstract::The synthesis of poly(lactic acid) through polycondensation of the lactic acid monomer gave weight average molecular weights (Mw) lower than 1.6 x 10(4), whereas ring-opening polymerization of lactides in bulk at 130 degrees C for 72 h using stannous octoate as catalyst in the concentration range from 0.003 to 0.8 wt%...


    pub_type: 杂志文章


    authors: Hyon SH,Jamshidi K,Ikada Y

    更新日期:1997-11-01 00:00:00

  • Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition.

    abstract::We investigated whether the post-expansion redifferentiation and cartilage tissue formation capacity of adult human nasal chondrocytes can be regulated by controlled modifications of scaffold composition and architecture. As a model system, we used poly(ethylene glycol)-terephthalate-poly(butylene)-terephthalate block...


    pub_type: 杂志文章


    authors: Miot S,Woodfield T,Daniels AU,Suetterlin R,Peterschmitt I,Heberer M,van Blitterswijk CA,Riesle J,Martin I

    更新日期:2005-05-01 00:00:00

  • Size-dependent radiosensitization of PEG-coated gold nanoparticles for cancer radiation therapy.

    abstract::Gold nanoparticles have been conceived as a radiosensitizer in cancer radiation therapy, but one of the important questions for primary drug screening is what size of gold nanoparticles can optimally enhance radiation effects. Herein, we perform in vitro and in vivo radiosensitization studies of 4.8, 12.1, 27.3, and 4...


    pub_type: 杂志文章


    authors: Zhang XD,Wu D,Shen X,Chen J,Sun YM,Liu PX,Liang XJ

    更新日期:2012-09-01 00:00:00

  • The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes.

    abstract::Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many siRNA polyplexes, however, is insufficient mRNA suppression. Given that modifying the sense strand of siRNA with 3' cholesterol (chol-siRNA) increases the activity of fre...


    pub_type: 杂志文章


    authors: Ambardekar VV,Han HY,Varney ML,Vinogradov SV,Singh RK,Vetro JA

    更新日期:2011-02-01 00:00:00

  • Influence of soluble suture factors on in vitro macrophage function.

    abstract::Suture materials may interact with immune competent cells and thereby affect localized immunity. Macrophages are central to the inflammatory response and coordinate wound healing. They are also involved in the clearance of foreign material, bacteria and malignant cells. We studied the influence of soluble factors asso...


    pub_type: 杂志文章


    authors: Uff CR,Scott AD,Pockley AG,Phillips RK

    更新日期:1995-03-01 00:00:00

  • In situ polymerization of tropoelastin in the absence of chemical cross-linking.

    abstract::Tropoelastin, the polypeptide monomer precursor of elastin, is covalently cross-linked to give stable elastic structures. We show here that elastic biomaterials can be generated from tropoelastin in the absence of the classically accepted cross-linking pathway. Under alkaline conditions tropoelastin proceeds through a...


    pub_type: 杂志文章


    authors: Mithieux SM,Tu Y,Korkmaz E,Braet F,Weiss AS

    更新日期:2009-02-01 00:00:00

  • Characterization of the complete fiber network topology of planar fibrous tissues and scaffolds.

    abstract::Understanding how engineered tissue scaffold architecture affects cell morphology, metabolism, phenotypic expression, as well as predicting material mechanical behavior has recently received increased attention. In the present study, an image-based analysis approach that provides an automated tool to characterize engi...


    pub_type: 杂志文章


    authors: D'Amore A,Stella JA,Wagner WR,Sacks MS

    更新日期:2010-07-01 00:00:00

  • A multifunctional heptamethine near-infrared dye for cancer theranosis.

    abstract::Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic ...


    pub_type: 杂志文章


    authors: Luo S,Tan X,Qi Q,Guo Q,Ran X,Zhang L,Zhang E,Liang Y,Weng L,Zheng H,Cheng T,Su Y,Shi C

    更新日期:2013-03-01 00:00:00

  • Cell growth on cordierite: an approach to the identification of reliable supports for continuous-flow solid-bed reactors.

    abstract::This study aimed to assess the biocompatibility of two cordierite ceramics (DF and Cord 1014), with similar chemical composition and different porosity, as a potential support for cell growth in a continuous-flow, solid-bed reactor. The Chinese hamster ovary (CHO) cell line transfected with HBV-DHFR recombinant plasmi...


    pub_type: 杂志文章


    authors: Orlandi L,Solmi R,Krajewski A,Bearzatto A,Biagini G,Ciccopiedi E,Ravaglioli A

    更新日期:1997-07-01 00:00:00

  • Tolerance induction by surface immobilization of Jagged-1 for immunoprotection of pancreatic islets.

    abstract::Although transplantation of pancreatic islets is a promising approach for treatment of type 1 diabetes mellitus, the engraftment efficiency of these islets is limited by host immune responses. Extensive efforts have been made to immunoisolate these islets by introducing barriers on the islet surface. To date, these ba...


    pub_type: 杂志文章


    authors: Izadi Z,Hajizadeh-Saffar E,Hadjati J,Habibi-Anbouhi M,Ghanian MH,Sadeghi-Abandansari H,Ashtiani MK,Samsonchi Z,Raoufi M,Moazenchi M,Izadi M,Nejad ASSH,Namdari H,Tahamtani Y,Ostad SN,Akbari-Javar H,Baharvand H

    更新日期:2018-11-01 00:00:00

  • Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.

    abstract::While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or lipid components. Her...


    pub_type: 杂志文章


    authors: Jackson MA,Bedingfield SK,Yu F,Stokan ME,Miles RE,Curvino EJ,Hoogenboezem EN,Bonami RH,Patel SS,Kendall PL,Giorgio TD,Duvall CL

    更新日期:2019-02-01 00:00:00

  • Engineered, self-assembled near-infrared photothermal agents for combined tumor immunotherapy and chemo-photothermal therapy.

    abstract::New combination therapy strategy, which takes the advantages of co-delivery two or more therapeutic agents in one nanocarrier platform, has been widely used in the clinic and achieved immense popularity in cancer treatment. Here, we have rationally developed a multifunctional platform using a self-assembly strategy to...


    pub_type: 杂志文章


    authors: Tao Y,Ju E,Liu Z,Dong K,Ren J,Qu X

    更新日期:2014-08-01 00:00:00