Modification of layered atelocollagen: enzymatic degradation and cytotoxicity evaluation.

Abstract:

:Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-linked with HMDIC. This should offer the possibility of programmed enzymatic degradation. These materials may be toxicologically acceptable as proven by the short-term test used for cytotoxicity evaluation.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Vizárová K,Bakos D,Rehákova M,Petríkova M,Panáková E,Koller J

doi

10.1016/0142-9612(95)98127-z

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

1217-21

issue

16

eissn

0142-9612

issn

1878-5905

pii

014296129598127Z

journal_volume

16

pub_type

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