In vitro behavior of silicate glass coatings on Ti6A14V.

abstract：:Complement activation by polymeric gene and drug delivery systems has been overlooked in the past. As more reports appear in the literature concerning immunogenicity of polymers and their impact on gene expression patterns, it is important to address possible immune side effects of polymers, namely complement activati...

journal_title：Biomaterials

authors： Merkel OM,Urbanics R,Bedocs P,Rozsnyay Z,Rosivall L,Toth M,Kissel T,Szebeni J

更新日期：2011-07-01 00:00:00

abstract：:The polymerization of N,N' carbonylbis (caprolactam) (CBC) and polyol in the presence of alcoholate as catalyst produced cross-linked poly(ester-urea)s via ring opening addition reaction. In contrast to conventional synthetic routes, the use of non-toxic CBC eliminates the need for toxic isocyanate-based monomers. The...

journal_title：Biomaterials

authors： Zimmermann J,Loontjens T,Scholtens BJ,Mülhaupt RR

更新日期：2004-06-01 00:00:00

abstract：:The ability to manipulate and control the surface properties, without altering the substrate properties, is of crucial importance in the designing of biomedical materials. In this work, surface-initiated atom transfer radical polymerization (ATRP) is employed to tailor the functionality of polycaprolactone (PCL) film ...

journal_title：Biomaterials

authors： Xu FJ,Wang ZH,Yang WT

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to determine the biocompatibility and osteoconductive potential of a high-strength canasite glass ceramic. Glass-ceramic rods were produced using the lost-wax casting technique and implanted in the mid-shafts rabbit femurs. Implants were harvested at 4, 13 and 22 weeks and prepared for light ...

journal_title：Biomaterials

authors： da Rocha Barros VM,Salata LA,Sverzut CE,Xavier SP,van Noort R,Johnson A,Hatton PV

更新日期：2002-07-01 00:00:00

abstract：:Well-characterised human osteoblastic bone marrow cell cultures are a useful in vitro tool to analyse bone tissue/biomaterials interactions. In this work, human bone marrow was cultured in experimental conditions described to favour osteoblastic differentiation and, serially passaged cells were cultured in two widely ...

journal_title：Biomaterials

authors： Coelho MJ,Cabral AT,Fernande MH

更新日期：2000-06-01 00:00:00

abstract：:Periosteum plays a pivotal role in vascularization, ossification and remodeling during the healing process of bone injury. However, there are few studies focused on the construction of artificial implants with periosteum-mimetic effect. To emulate the primary role of natural periosteum or endosteal tissues in bone reg...

journal_title：Biomaterials

authors： Yang G,Liu H,Cui Y,Li J,Zhou X,Wang N,Wu F,Li Y,Liu Y,Jiang X,Zhang S

更新日期：2021-01-01 00:00:00

abstract：:Covalent immobilization of cell-adhesive proteins such as collagen and fibronectin on to the surface of poly(vinyl alcohol) hydrogel was investigated by using diisocyanates, polyisocyanates, and cyanogen bromide. It was found that 0.5 and 12 micrograms/cm2 of collagen were immobilized on to the surface by using hexame...

journal_title：Biomaterials

authors： Kobayashi H,Ikada Y

更新日期：1991-10-01 00:00:00

abstract：:Cell sheet technology has emerged as an important tissue engineering approach. Adipose-derived stem cells (ASCs) have valuable applications in regenerative medicine, but their stemness and differentiation capabilities in the cell sheet format have not been well investigated. In this study, we found that l-ascorbate 2-...

journal_title：Biomaterials

authors： Yu J,Tu YK,Tang YB,Cheng NC

更新日期：2014-04-01 00:00:00

abstract：:Polyetheretherketone-hydroxyapatite composites were developed as alternative materials for load-bearing orthopedic applications. The amount of hydroxyapatite (HA) incorporated into the polyetheretherketone (PEEK) polymer matrix ranges from 5 to 40 vol% and these materials were successfully fabricated by injection mold...

journal_title：Biomaterials

authors： Abu Bakar MS,Cheng MH,Tang SM,Yu SC,Liao K,Tan CT,Khor KA,Cheang P

更新日期：2003-06-01 00:00:00

abstract：:An artificial receptor for creatinine was synthesized by the method of molecularly imprinted polymer (MIP). beta-Cyclodextrin was used as a monomer cross-linked with epichlorohydrin in the presence of creatinine, which was a template for the imprinting. Different molar ratios of monomer to template were used to synthe...

journal_title：Biomaterials

authors： Tsai HA,Syu MJ

更新日期：2005-05-01 00:00:00

abstract：:Here we document the complete process of bioresorption and bone replacement of rods made of forged composites of unsintered hydroxyapatite particles/poly l-lactide (F-u-HA/PLLA) implanted in the femoral medullary cavities of rabbits. Bioresorption, osteoconductive bioactivity and bone replacement were compared in thre...

journal_title：Biomaterials

authors： Shikinami Y,Matsusue Y,Nakamura T

更新日期：2005-09-01 00:00:00

abstract：:Traditional therapeutic interventions against abnormal gene expression in disease states at the level of expressed proteins are becoming increasingly difficult due to poor selectivity, off-target effects and associated toxicity. Upstream catalytic targeting of specific RNA sequences offers an alternative platform for ...

journal_title：Biomaterials

authors： Staroseletz Y,Williams A,Burusco KK,Alibay I,Vlassov VV,Zenkova MA,Bichenkova EV

更新日期：2017-01-01 00:00:00

abstract：:Targeted therapy is needed for hepatitis B virus (HBV)-mediated hepatocellular carcinoma (HCC) which shows overexpression of HBV surface antigen (HBsAg). We previously developed scFv15, a human single-chain antibody against HBsAg. Here we tested the strategic feasibility of scFv15-mediated delivery of apoptotic effect...

journal_title：Biomaterials

authors： Yan B,Ouyang Q,Zhao Z,Cao F,Wang T,Jia X,Meng Y,Jiang S,Liu J,Chen R,Jia L,Zhang R,Wen W,Jin B,Chen S,Zhao J,Yang A

更新日期：2013-07-01 00:00:00

abstract：:During organogenesis groups of differentiating cells self-organize into a series of structural intermediates with defined architectural forms. Evidence is emerging that such architectural forms are important in guiding cell fate, yet in vitro methods to guide cell fate have focused primarily on un-patterned exposure o...

journal_title：Biomaterials

authors： Soleas JP,D'Arcangelo E,Huang L,Karoubi G,Nostro MC,McGuigan AP,Waddell TK

更新日期：2020-09-01 00:00:00

abstract：:The large surface area of highly porous titanium structures produced by additive manufacturing can be modified using biofunctionalizing surface treatments to improve the bone regeneration performance of these otherwise bioinert biomaterials. In this longitudinal study, we applied and compared three types of biofunctio...

journal_title：Biomaterials

authors： Amin Yavari S,van der Stok J,Chai YC,Wauthle R,Tahmasebi Birgani Z,Habibovic P,Mulier M,Schrooten J,Weinans H,Zadpoor AA

更新日期：2014-08-01 00:00:00

abstract：:Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a refined method for differ...

journal_title：Biomaterials

authors： Natividad-Diaz SL,Browne S,Jha AK,Ma Z,Hossainy S,Kurokawa YK,George SC,Healy KE

更新日期：2019-02-01 00:00:00

abstract：:Understanding how nanovectors transport DNA molecules through cell membranes is of great importance in gene therapy. In this paper, we systematically investigate the mechanism of cellular uptake of cationic polymeric nanovectors containing DNA molecules through dissipative particle dynamics simulations. Our results sh...

journal_title：Biomaterials

authors： Ding HM,Ma YQ

更新日期：2013-11-01 00:00:00

abstract：:In the present study, we tested the hypothesis that electroporation-mediated transfer of Runx2, Osterix, or both genes enhances the in vitro and in vivo osteogenesis from adipose stem cells (ASCs). ASCs were transfected with Runx2, Osterix, or both genes using electroporation, and further cultured in monolayer or in P...

journal_title：Biomaterials

authors： Lee JS,Lee JM,Im GI

更新日期：2011-01-01 00:00:00

abstract：:Microstructure of thermal sprayed hydroxyapatite (HA) splats was characterized using transmission electron microscopy (TEM), and the formation mechanisms of micropores within the splats were investigated with the aid of simulated body fluids (SBF). High-velocity oxy-fuel and direct current (DC) plasma spray techniques...

journal_title：Biomaterials

authors： Li H,Khor KA,Cheang P

更新日期：2004-08-01 00:00:00

abstract：:Polydimethacrylate resins were prepared by photopolymerization of Bis-GMA, TEGDMA, UDMA or Bis-EMA (4) monomer, initiated by camphoroquinone/N,N-dimethylaminoethyl methacrylate system. The study of physical properties of these resins showed that TEGDMA seems to create the most dense polymer network, which however is t...

journal_title：Biomaterials

authors： Sideridou I,Tserki V,Papanastasiou G

更新日期：2003-02-01 00:00:00

abstract：:A photografting technique to produce functional groups of silanol able to induce apatite nucleation was attempted on polyethylene substrate for biomimetic formation of bone-mineral-like apatite layer on its surface. The polyethylene surface was subjected to vapor-phase photografting of vinyltrimethoxysilane and subseq...

journal_title：Biomaterials

authors： Kim HM,Uenoyama M,Kokubo T,Minoda M,Miyamoto T,Nakamura T

更新日期：2001-09-01 00:00:00

abstract：:The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and improve graft survival. Localized drug delivery has the potential to improve transplant outcomes by providing sustained exposure to efficacious drug concentrations...

journal_title：Biomaterials

authors： Chang CA,Akinbobuyi B,Quintana JM,Yoshimatsu G,Naziruddin B,Kane RR

更新日期：2018-03-01 00:00:00

abstract：:Polypyrrole (PPy) is a conducting polymer and is obtained electrochemically on an electrode such as indium-tin oxide (ITO). In this study, in order to develop a novel cell-culture system which makes it possible to communicate with cultured mammalian cells, bovine adrenal chromaffin cells were cultured on PPy-coated IT...

journal_title：Biomaterials

authors： Aoki T,Tanino M,Sanui K,Ogata N,Kumakura K

更新日期：1996-10-01 00:00:00

abstract：:Space experimentation of cardiomyocyte differentiation from human induced pluripotent stem cells offers an exciting opportunity to explore the potential of these cells for disease modeling, drug discovery and regenerative medicine. Previous studies on the International Space Station were done with 2D non-cryopreserved...

journal_title：Biomaterials

authors： Rampoldi A,Jha R,Fite J,Boland G,Xu C

更新日期：2021-01-11 00:00:00

abstract：:Hydrogels are frequently employed as medical device biomaterials due to their advantageous biological properties, e.g. resistance to infection and encrustation, biocompatibility; however, their poor mechanical properties generally limit the scope of application to coatings of medical devices. To address this limitatio...

journal_title：Biomaterials

authors： Jones DS,McLaughlin DW,McCoy CP,Gorman SP

更新日期：2005-05-01 00:00:00

abstract：:We introduce a general class of mixture models suitable to describe water-dependent degradation and erosion of biodegradable polymers in conjunction with drug release. The ability to predict and quantify degradation and erosion has direct impact in a variety of biomedical applications and is a useful design tool for b...

journal_title：Biomaterials

authors： Soares JS,Zunino P

更新日期：2010-04-01 00:00:00

abstract：:We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe(2)O(4)) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs wate...

journal_title：Biomaterials

authors： Yang H,Zhang C,Shi X,Hu H,Du X,Fang Y,Ma Y,Wu H,Yang S

更新日期：2010-05-01 00:00:00

abstract：:The design of synthetic polymers may affect structural features of inflammatory cells, for example the expression of endogenous sugar receptor molecules like lectins in macrophages and foreign body giant multinucleate cells. This characteristic was studied histochemically by use of biotinylated (neo)glycoproteins. The...

journal_title：Biomaterials

authors： Smetana K Jr,Gabius HJ,Vacík J,Jelínková M,Lukás J

更新日期：1995-10-01 00:00:00

abstract：:We studied non-implanted ultra-high molecular weight polyethylene (UHMWPE) knee components, that were gamma-sterilized in air and shelf-aged during 6 and 7 years, to explore fracture mechanisms in the degraded material. Prior to the fractography study, we assessed degradation through FTIR and optical density measureme...

journal_title：Biomaterials

authors： Puértolas JA,Larrea A,Gómez-Barrena E

更新日期：2001-08-01 00:00:00

abstract：:The present study investigated the ectopic osteoinduction and early degradation of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded porous beta-tricalcium phosphate (beta-TCP) in mice. The porous beta-TCP with 50 microg of rhBMP-2 (n = 25) and porous beta-TCP (control group, n = 25) were implanted into ...

journal_title：Biomaterials

authors： Liang G,Yang Y,Oh S,Ong JL,Zheng C,Ran J,Yin G,Zhou D

更新日期：2005-07-01 00:00:00