Dexamethasone-conjugated DNA nanotubes as anti-inflammatory agents in vivo.

abstract：:Craniofacial skeletal muscle is composed of approximately 60 muscles, which have critical functions including food uptake, eye movements and facial expressions. Although craniofacial muscles have significantly different embryonic origin, most current skeletal muscle differentiation protocols using human induced plurip...

journal_title：Biomaterials

authors： Kim E,Wu F,Wu X,Choo HJ

更新日期：2020-07-01 00:00:00

abstract：:Electroconductive hydrogels (ECHs) are composite biomaterials that bring together the redox switching and electrical properties of inherently conductive electroactive polymers (CEPs) with the facile small molecule transport, high hydration levels and biocompatibility of cross-linked hydrogels. General methods for the ...

journal_title：Biomaterials

authors： Guiseppi-Elie A

更新日期：2010-04-01 00:00:00

abstract：:The translation of experimental stroke research from the laboratory to successful clinical practice remains a formidable challenge. We previously reported that PEGylated-lipid nanoparticles (PLNs) effectively transport across the blood-brain barrier along with less inflammatory responses. In the present study, PLNs co...

journal_title：Biomaterials

authors： Lu YM,Huang JY,Wang H,Lou XF,Liao MH,Hong LJ,Tao RR,Ahmed MM,Shan CL,Wang XL,Fukunaga K,Du YZ,Han F

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to evaluate the in vivo response following implantation into a rat model of three innovative hyaluronan derivatives for clinical use: HYAFF 7, HYAFF 11 and HYAFF 11p75 (respectively, the 100% ethyl ester, 100% and 75% benzyl esters). The tissue reaction evoked by films of these new biomateria...

journal_title：Biomaterials

authors： Campoccia D,Hunt JA,Doherty PJ,Zhong SP,O'Regan M,Benedetti L,Williams DF

更新日期：1996-05-01 00:00:00

abstract：:Dacron velour is often used to anchor a percutaneous device, like the catheter used in peritoneal dialysis. However, exit-site infections complicate this method of dialysis and are supposed to be related to the design of the catheter. In animal experiments, a percutaneous device provided with a titanium fibre mesh to ...

journal_title：Biomaterials

authors： Paquay YC,de Ruijter JE,van der Waerden JP,Jansen JA

更新日期：1996-06-01 00:00:00

abstract：:This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...

journal_title：Biomaterials

authors： Hayashi K,Mashima T,Uenoyama K

更新日期：1999-01-01 00:00:00

abstract：:An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...

journal_title：Biomaterials

authors： Assal Y,Mie M,Kobatake E

更新日期：2013-04-01 00:00:00

abstract：:Combination therapy is usually considered as a promising strategy owing to its advantages such as reduced doses, minimized side effects and improved therapeutic efficiency in a variety of diseases including diabetes. Here we synthesized a new highly intracellular stimuli-sensitive chitosan-graft-metformin (CS-MET) pro...

journal_title：Biomaterials

authors： Wang FZ,Xie ZS,Xing L,Zhang BF,Zhang JL,Cui PF,Qiao JB,Shi K,Cho CS,Cho MH,Xu X,Li P,Jiang HL

更新日期：2015-12-01 00:00:00

abstract：:Mesenchymal condensation is a pre-requisite of chondrogenesis during embryonic development. The current understanding of chondrogenesis is limited in terms of chondrogenic condensation mechanisms. In particular, the role of matrix stiffness on homotypic cell-cell interactions leading to the establishment of distinct a...

journal_title：Biomaterials

authors： Ghosh S,Laha M,Mondal S,Sengupta S,Kaplan DL

更新日期：2009-11-01 00:00:00

abstract：:We report a new template-directed method for the fabrication of hydroxyapatite (HAp) sponges by using amino-acid-coated HAp nanoparticles dispersed within a viscous polysaccharide (dextran sulfate) matrix, and describe the use of these materials for the viability and proliferation of human bone marrow stromal cells. T...

journal_title：Biomaterials

authors： Gonzalez-McQuire R,Green D,Walsh D,Hall S,Chane-Ching JY,Oreffo RO,Mann S

更新日期：2005-11-01 00:00:00

abstract：:Reconstruction of the genitourinary tract, using engineered urological tissues, requires a mechanically stable biodegradable and biocompatible scaffold and cultured cells. Such engineered autologous tissue would have many clinical implications. In this study a highly porous biodegradable polyesterurethane-foam, DegraP...

journal_title：Biomaterials

authors： Danielsson C,Ruault S,Simonet M,Neuenschwander P,Frey P

更新日期：2006-03-01 00:00:00

abstract：:Biodegradable tissue engineering scaffolds are commonly fabricated from poly(lactide-co-glycolide) (PLGA) or similar polyesters that degrade by hydrolysis. PLGA hydrolysis generates acidic breakdown products that trigger an accelerated, autocatalytic degradation mechanism that can create mismatched rates of biomateria...

journal_title：Biomaterials

authors： Martin JR,Gupta MK,Page JM,Yu F,Davidson JM,Guelcher SA,Duvall CL

更新日期：2014-04-01 00:00:00

abstract：:Monocytes are actively recruited from the circulation into developing atherosclerotic plaques. In the plaque, monocytes differentiate into macrophages and eventually form foam cells. Continued accumulation of foam cells can lead to plaque rupture and subsequent myocardial infarction. X-ray computed tomography (CT) is ...

journal_title：Biomaterials

authors： Chhour P,Naha PC,O'Neill SM,Litt HI,Reilly MP,Ferrari VA,Cormode DP

更新日期：2016-05-01 00:00:00

abstract：:The purpose of this study is to analyze the roles of two non-invasive techniques, bone scintigraphy and resonance frequency analysis (RFA), in the osseointegration assessment. Sixty implants with sandblasted/acid-etched (SA) or machined (MA) surface were placed into the distal femur condyles of 30 rabbits. At 1, 2, 4,...

journal_title：Biomaterials

authors： Zhou Y,Jiang T,Qian M,Zhang X,Wang J,Shi B,Xia H,Cheng X,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:Human stem cells are vulnerable to unfavorable conditions, and their transportation relies on costly and inconvenient cryopreservation. We report here that human mesenchymal stem cells (MSC) in spheroids survived ambient conditions (AC) many days longer than in monolayer. Under AC, the viability of MSC in spheroids re...

journal_title：Biomaterials

authors： Jiang B,Yan L,Miao Z,Li E,Wong KH,Xu RH

更新日期：2017-07-01 00:00:00

abstract：:At the present time, three poly(ortho ester) systems have been described. The first one was developed at the Alza Corporation and is prepared by the transesterification reaction between a diol and diethoxytetrahydrofuran. It is currently marketed under the trade name of Alzamer. A second poly(ortho ester) system, deve...

journal_title：Biomaterials

authors： Heller J

更新日期：1990-11-01 00:00:00

abstract：:Breast cancer is associated with high mortality due to tumor metastasis. The anti-metastasis efficacy of photochemotherapy is strictly limited by poor targeting capability with respect to circulating tumor cells (CTCs) in blood and lymph. Herein, we decorate the platelet membrane (PM) on a surface of nanoparticles (NP...

journal_title：Biomaterials

authors： Ye H,Wang K,Wang M,Liu R,Song H,Li N,Lu Q,Zhang W,Du Y,Yang W,Zhong L,Wang Y,Yu B,Wang H,Kan Q,Zhang H,Wang Y,He Z,Sun J

更新日期：2019-06-01 00:00:00

abstract：:Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cation...

journal_title：Biomaterials

authors： Kosmala JD,Henthorn DB,Brannon-Peppas L

更新日期：2000-10-01 00:00:00

abstract：:Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...

journal_title：Biomaterials

authors： Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

更新日期：2013-06-01 00:00:00

abstract：:In vivo tracking of transplanted stem cells has been a central aim of stem cell therapy. Although many tracking systems have been introduced, no method has yet been validated for clinical applications. We developed a novel sophisticated peptide (GV1001) that mimics hTERT (human telomerase reverse transcriptase) and an...

journal_title：Biomaterials

authors： Park HH,Lee KY,Park DW,Choi NY,Lee YJ,Son JW,Kim S,Moon C,Kim HW,Rhyu IJ,Koh SH

更新日期：2018-02-01 00:00:00

abstract：:The effect of hirudin, a known inhibitor of thrombin, was evaluated for whole blood samples in terms of platelet deposition/adhesion to a non-biological test surface (tetrafluoroethylene-propylene copolymer), adenosine diphosphate (ADP) release and reduction in platelet count during laminar shear flow for a shear rate...

journal_title：Biomaterials

authors： Alkhamis TM,Beissinger RL,Chediak JR

更新日期：1993-09-01 00:00:00

abstract：:Sol-gel derived porous silica carriers for the controlled release of proteins were synthesized using a room temperature process. The materials are intended to serve as both substrates for bone growth as well as to allow incorporated proteins such as growth factors to diffuse out and stimulate cell function and tissue ...

journal_title：Biomaterials

authors： Santos EM,Radin S,Ducheyne P

更新日期：1999-09-01 00:00:00

abstract：:Surface protein modification with poly(ethylene glycol) (PEG) can inhibit acute thrombosis on damaged vascular and biomaterial surfaces by blocking surface protein-platelet interactions. However, the feasibility of employing protein reactive PEGs to limit intravascular and biomaterial thrombosis in vivo is contingent ...

journal_title：Biomaterials

authors： Xu H,Kaar JL,Russell AJ,Wagner WR

更新日期：2006-06-01 00:00:00

abstract：:Despite the promise for stem cell-based tissue engineering for regenerative therapy, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells. A combination of channeled porous silk scaffolds and prevascularization with endothelial cells ...

journal_title：Biomaterials

authors： Zhang W,Wray LS,Rnjak-Kovacina J,Xu L,Zou D,Wang S,Zhang M,Dong J,Li G,Kaplan DL,Jiang X

更新日期：2015-07-01 00:00:00

abstract：:A challenge in combating many major diseases is breaching the skin's tough outer layer (the stratum corneum (SC)) and delivering drugs and genes into the underlying abundant immunologically sensitive viable epidermal cells with safe, practical physical technologies. To achieve this effectively and accurately, design i...

journal_title：Biomaterials

authors： Kendall MA,Chong YF,Cock A

更新日期：2007-11-01 00:00:00

abstract：:This study examined the antibacterial activity of prepolymerized resin filler, in which the bactericide quaternary ammonium was immobilized. The experimental filler was prepared by grinding prepolymerized resin blocks of methacrylate monomers, silica particles, and the antibacterial monomer methacryloyloxydodecylpyrid...

journal_title：Biomaterials

authors： Imazato S,Ebi N,Takahashi Y,Kaneko T,Ebisu S,Russell RR

更新日期：2003-09-01 00:00:00

abstract：:The surface of soft contact lenses made of crosslinked poly(2-hydroxyethyl methacrylate). pHEMA, has been investigated with atomic force microscopy in contact mode. The friction force and adhesive force measurements were able to differentiate the non-crosslinked pHEMA chains from the surface of the crosslinked pHEMA n...

journal_title：Biomaterials

authors： Kim SH,Marmo C,Somorjai GA

更新日期：2001-12-01 00:00:00

abstract：:The in vitro labelling of cultured cells with iron oxide nanoparticles (NPs) is a frequent practice in biomedical research. To date, the potential cytotoxicity of these particles remains an issue of debate. In the present study, 4 different NP types (dextran-coated Endorem, carboxydextran-coated Resovist, lipid-coated...

journal_title：Biomaterials

authors： Soenen SJ,Himmelreich U,Nuytten N,De Cuyper M

更新日期：2011-01-01 00:00:00

abstract：:Xenogeneic extracellular matrix (ECM) can be harvested and configured to function as a bioscaffold for tissue and organ reconstruction. The mechanical properties of the ECM vary depending upon the tissue from which it is harvested. Likewise, the manufacturing steps required to develop ECMs into medical grade devices w...

journal_title：Biomaterials

authors： Freytes DO,Badylak SF,Webster TJ,Geddes LA,Rundell AE

更新日期：2004-05-01 00:00:00

abstract：:Platelet-derived growth factor BB (PDGF-BB) was an important inductive factor during wound healing, but the lack of efficient delivery system limited its clinical application. Here, a peptide of seven amino acids was firstly utilized to engineer PDGF-BB to construct a collagen-targeting system. This peptide functioned...

journal_title：Biomaterials

authors： Lin H,Chen B,Sun W,Zhao W,Zhao Y,Dai J

更新日期：2006-11-01 00:00:00