Abstract:
:Personalized oncology significantly relies on the development of cancer theranostic agents to integrate cancer therapeutics and diagnostics. Current most common strategy for development of such multifunctional agents requires multistep chemical conjugation with cancer targeted ligands, contrast agents and therapeutic agents. Here we report the chemical synthesis and biological characterization of a new heptamethine dye, termed as IR-808DB, natively with multifunctional characteristics of cancer targeting, near-infrared fluorescence imaging, and efficient anticancer activity. The tumor inhibition effect of IR-808DB is higher than that of cyclophosphamide (CTX) toward a broad spectrum of tumor xenograft models. These findings provide IR-808DB a promising prospect as a new cancer theranostic agent that would enable integration of cancer targeted therapeutics and diagnostics without requirement of multi-component chemical conjugation.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Luo S,Tan X,Qi Q,Guo Q,Ran X,Zhang L,Zhang E,Liang Y,Weng L,Zheng H,Cheng T,Su Y,Shi Cdoi
10.1016/j.biomaterials.2012.11.057subject
Has Abstractpub_date
2013-03-01 00:00:00pages
2244-51issue
9eissn
0142-9612issn
1878-5905pii
S0142-9612(12)01329-4journal_volume
34pub_type
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