Developing bioactive composite materials for tissue replacement.

abstract：:As a common receptor for three myelin associated inhibitors, Nogo-66 receptor (NgR) mediates their inhibitory activities on neurite outgrowth in the adult mammalian central nervous system (CNS). Therapeutic vaccination protocol targeting NgR emulsified with Freund's adjuvant (FA) has been used in spinal cord injury (S...

journal_title：Biomaterials

authors： Wang YT,Lu XM,Zhu F,Huang P,Yu Y,Zeng L,Long ZY,Wu YM

更新日期：2011-11-01 00:00:00

abstract：:The effect of PEGylation on the aqueous solution properties and cell membrane disruptive activity of a pH-responsive pseudo-peptide, poly(l-lysine iso-phthalamide), has been investigated by dynamic light scattering, haemolysis and lactate dehydrogenase (LDH) assays. Intracellular trafficking of the polymers has been e...

journal_title：Biomaterials

authors： Chen R,Yue Z,Eccleston ME,Slater NK

更新日期：2008-11-01 00:00:00

abstract：:Bone morphogenetic protein-2/absorbable collagen sponge (BMP-2/ACS) implants have been approved for clinical use to induce bone regeneration. We previously showed that exaggerated inflammation characterized by elevated level of inflammatory cytokines including TNF-α, IL-1β, and IL-6 has been shown to inhibit BMP-2/ACS...

journal_title：Biomaterials

authors： Huang RL,Chen G,Wang W,Herller T,Xie Y,Gu B,Li Q

更新日期：2015-10-01 00:00:00

abstract：:Hierarchical structured nanomaterials with diverse functionality, such as magnetic susceptibility, stimuli-responsiveness, environmental sensing and biocompatibility, are highly sought after for biomedicine and biodetection alike. In this study, we designed and fabricated a new kind of multifunctional core/shell nanos...

journal_title：Biomaterials

authors： Li D,Zhang YT,Yu M,Guo J,Chaudhary D,Wang CC

更新日期：2013-10-01 00:00:00

abstract：:The purpose of this work was to investigate new bone formation in macroporous iron foams coated with strontium (FeSr) or bisphosphonate (FeBiP) compared to plain iron foam (Fe) and empty defect in a critical size metaphyseal bone defect model in ovariectomized rats. 60 female rats were subjected to bilateral ovariecto...

journal_title：Biomaterials

authors： Ray S,Thormann U,Eichelroth M,Budak M,Biehl C,Rupp M,Sommer U,El Khassawna T,Alagboso FI,Kampschulte M,Rohnke M,Henß A,Peppler K,Linke V,Quadbeck P,Voigt A,Stenger F,Karl D,Schnettler R,Heiss C,Lips KS,Alt V

更新日期：2018-03-01 00:00:00

abstract：:To develop efficient carriers for inner ear drug delivery, we prepared four kinds of phospholipid-based nanoparticles: neutral, anionic, cationic, and cationic-PEG (polyethyleneglycol) particles. PEG was used to maintain long-term particle circulation in the perilymph, avoiding non-specific binding of particles to pro...

journal_title：Biomaterials

authors： Yang KJ,Son J,Jung SY,Yi G,Yoo J,Kim DK,Koo H

更新日期：2018-07-01 00:00:00

abstract：:For clinical application of human embryonic stem cells (hESCs), it is critical to develop hESC culture techniques that completely exclude the use of animal feeder cells, mitotic inhibition, and enzyme treatments used in conventional hESC culture systems. Toward this goal, we attempted to maintain hESCs and induced plu...

journal_title：Biomaterials

authors： Hwang ST,Kang SW,Lee SJ,Lee TH,Suh W,Shim SH,Lee DR,Taite LJ,Kim KS,Lee SH

更新日期：2010-11-01 00:00:00

abstract：:In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/...

journal_title：Biomaterials

authors： Zhang Z,Zhang M,Chen S,Horbett TA,Ratner BD,Jiang S

更新日期：2008-11-01 00:00:00

abstract：:It was reported that nanoparticles with polysorbate 80 (Tween 80, T-80) coating represented tools used for delivering drugs to brain. Nevertheless, disputations were once aroused for some complications. Aimed to have a better understanding of the specific role of T-80 coating on nanoparticles and simplify the problem,...

journal_title：Biomaterials

authors： Sun W,Xie C,Wang H,Hu Y

更新日期：2004-07-01 00:00:00

abstract：:The effect of hirudin, a known inhibitor of thrombin, was evaluated for whole blood samples in terms of platelet deposition/adhesion to a non-biological test surface (tetrafluoroethylene-propylene copolymer), adenosine diphosphate (ADP) release and reduction in platelet count during laminar shear flow for a shear rate...

journal_title：Biomaterials

authors： Alkhamis TM,Beissinger RL,Chediak JR

更新日期：1993-09-01 00:00:00

abstract：:Tumor-homing cytotoxic stem cell (SC) therapy is a promising new approach for treating the incurable brain cancer glioblastoma (GBM). However, problems of retaining cytotoxic SCs within the post-surgical GBM resection cavity are likely to significantly limit the clinical utility of this strategy. Here, we describe a n...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Hingtgen SD

更新日期：2016-04-01 00:00:00

abstract：:Fluorapatite (FA)-collagen composites were synthesized via a biomimetic coprecipitation method in order to improve the structural stability and cellular responses. Different amounts of ammonium fluoride (NH4F), acting as a fluorine source for FA, were added to the precipitation of the composites. The precipitated comp...

journal_title：Biomaterials

authors： Yoon BH,Kim HW,Lee SH,Bae CJ,Koh YH,Kong YM,Kim HE

更新日期：2005-06-01 00:00:00

abstract：:Osteoclasts resorb bone at surfaces, leaving behind pits and trails where both mineral and organic phases of bone have been dissolved. Rough surface structures are deliberately imparted to synthetic implants, in order to improve osseointegration. The aim of this study is to characterize osteoclastic resorption pits on...

journal_title：Biomaterials

authors： Hefti T,Frischherz M,Spencer ND,Hall H,Schlottig F

更新日期：2010-10-01 00:00:00

abstract：:Porous nanostructure with its unique properties is found to be able to hold promise in drug delivery. We fabricated the one-dimensional titanium dioxide whiskers (TiO2 Ws) and designed a strategy to explore their drug delivery application and anti-tumor function combined with daunorubicin (DNR). We observed good bioco...

journal_title：Biomaterials

authors： Li Q,Wang X,Lu X,Tian H,Jiang H,Lv G,Guo D,Wu C,Chen B

更新日期：2009-09-01 00:00:00

abstract：:A cardiomyocyte-targeted Fas siRNA delivery system was developed using prostaglandin E(2) (PGE(2))-modified siRNA polyplexes formed by a reducible poly(amido amine) to inhibit cardiomyocyte apoptosis. PGE(2), which was used as a specific ligand for cardiomyocyte targeting, was conjugated to the terminal-end of the sen...

journal_title：Biomaterials

authors： Kim SH,Jeong JH,Ou M,Yockman JW,Kim SW,Bull DA

更新日期：2008-11-01 00:00:00

abstract：:Targeted theranostic nano-system integrating functions of both diagnosis and therapy shows great potential for improving diagnosis and therapeutic efficacy. Herein, multifunctional nanoparticle based on activatable hyaluronic acid (HA) conjugating two near-infrared (NIR) dyes of Cy5.5 and IR825 was successfully design...

journal_title：Biomaterials

authors： Liang X,Fang L,Li X,Zhang X,Wang F

更新日期：2017-07-01 00:00:00

abstract：:Bone tissue is an anisotropic non-homogeneous composite material composed of inorganic, bone mineral fibres (hydroxyapatite) embedded in an organic matrix (type I collagen and non-collagenous proteins). Factors contributing to the overall mechanical behaviour include constituent volume fraction, mechanical properties,...

journal_title：Biomaterials

authors： Walsh WR,Guzelsu N

更新日期：1994-01-01 00:00:00

abstract：:We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe(2)O(4)) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs wate...

journal_title：Biomaterials

authors： Yang H,Zhang C,Shi X,Hu H,Du X,Fang Y,Ma Y,Wu H,Yang S

更新日期：2010-05-01 00:00:00

abstract：:Cell detachment by laminar shear stresses was used to characterize cellular interactions with hydrophilic glass and hydrophobic silane. In this study, we examined whether smaller, rounder cells were preferentially detached by laminar flow, and whether cell detachment occurred by dissociation of adhesion proteins and t...

journal_title：Biomaterials

authors： Truskey GA,Proulx TL

更新日期：1993-01-01 00:00:00

abstract：:Three-dimensional constructs formed by cells embedded in an exogenous scaffold could not represent a faithful in vitro replica of native and functional tissues. In this work we produced an endogenous human skin equivalent by means of a tissue engineering process that induces the full morphogenesis of functional dermal...

journal_title：Biomaterials

authors： Casale C,Imparato G,Urciuolo F,Netti PA

更新日期：2016-09-01 00:00:00

abstract：:An in vitro perfusion system was used to study the platelet reactivity of the following vascular graft materials when tested with human blood: expanded polytetrafluoroethylene (ePTFE), crimped Dacron Bionit (DB) and preclotted Dacron Bionit (DB/PC). These materials were simultaneously compared to silicone rubber (SR) ...

journal_title：Biomaterials

authors： Kottke-Marchant K,Anderson JM,Rabinovitch A

更新日期：1986-11-01 00:00:00

abstract：:The physiological activity of hyaluronic acid (HA) polymers and oligomers makes it a promising material for a variety of applications. The development of HA-hydrogel scaffolds with improved mechanical stability against degradation and biochemical functionality may enhance their application to tissue engineering. In th...

journal_title：Biomaterials

authors： Segura T,Anderson BC,Chung PH,Webber RE,Shull KR,Shea LD

更新日期：2005-02-01 00:00:00

abstract：:Percutaneous implants are commonly associated with several problems, and different failure modes have been described. Infections constitute one serious complication which may lead to the removal of the implant. In contrast to infections around polymer implants, infections around skin-penetrating titanium implants anch...

journal_title：Biomaterials

authors： Holgers KM,Ljungh A

更新日期：1999-07-01 00:00:00

abstract：:We studied the adhesion and proliferation of human endothelial cells on photochemically modified polytetrafluoroethylene samples. The polymer surfaces were modified by exposure to the ultraviolet light of a Xe(2)(*)-excimer lamp at a wavelength of 172 nm in an ammonia atmosphere. Treatment times were between 10 and 20...

journal_title：Biomaterials

authors： Gumpenberger T,Heitz J,Bäuerle D,Kahr H,Graz I,Romanin C,Svorcik V,Leisch F

更新日期：2003-12-01 00:00:00

abstract：:Magnesium (Mg), a potential biodegradable material, has recently received increasing attention due to its unique antibacterial property. However, rapid corrosion in the physiological environment and potential toxicity limit clinical applications. In order to improve the corrosion resistance meanwhile not compromise th...

journal_title：Biomaterials

authors： Qin H,Zhao Y,An Z,Cheng M,Wang Q,Cheng T,Wang Q,Wang J,Jiang Y,Zhang X,Yuan G

更新日期：2015-06-01 00:00:00

abstract：:The combined use of natural ECM components and synthetic materials offers an attractive alternative to fabricate hydrogel-based tissue engineering scaffolds to study cell-matrix interactions in three-dimensions (3D). A facile method was developed to modify gelatin with cysteine via a bifunctional PEG linker, thus intr...

journal_title：Biomaterials

authors： Fu Y,Xu K,Zheng X,Giacomin AJ,Mix AW,Kao WJ

更新日期：2012-01-01 00:00:00

abstract：:The torque-tension characteristics of standard, conical and flanged external fixator pins and a cortical screw were compared using a commercially available testing apparatus. The flanged pin and the screw were similar in behaviour, and converted torque into tension more efficiently than conical and standard external f...

journal_title：Biomaterials

authors： Oni OO,Batchelor JS

更新日期：1995-11-01 00:00:00

abstract：:The aim of the present study was to test the hypothesis that oligonucleotides can be used for anchorage and slow release of osteogenic growth factors such as BMP to enhance the osteogenic activity of a titanium implant surface. Strands of 60-mer non-coding DNA oligonucleotides (ODN) were bound to an acid-etched sandbl...

journal_title：Biomaterials

authors： Schliephake H,Bötel C,Förster A,Schwenzer B,Reichert J,Scharnweber D

更新日期：2012-02-01 00:00:00

abstract：:Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds were engineered to promote contractile smooth muscle cell (SMC) phenotype via controlled release of heparin. The scaffold design was evaluated by quantifying the effects of free heparin on SMC phenotype, engineering hydrogels to provide controlled release of ...

journal_title：Biomaterials

authors： Beamish JA,Geyer LC,Haq-Siddiqi NA,Kottke-Marchant K,Marchant RE

更新日期：2009-10-01 00:00:00

abstract：:Nanocarrier for augmenting the efficacy of reactive oxygen species (ROS) by tumor microenvironment (TME) has become an emerging strategy for cancer treatment. Herein, a smart biodegradable drug delivery nanoplatform with mitochondrial-targeted ability, pH-responsive drug release and enzyme-like catalytic function is d...

journal_title：Biomaterials

authors： An J,Hu YG,Cheng K,Li C,Hou XL,Wang GL,Zhang XS,Liu B,Zhao YD,Zhang MZ

更新日期：2020-03-01 00:00:00