Abstract：
:Bioactive composites composed of hydroxyapatite containing glass (HA-G) as a coating and titanium (Ti) or titanium alloy implants as a substrate were prepared by the Cullet method. This method results in the HA-G coating layer on the substrate with a compositional gradient in HA concentration. The results of in vitro and in vivo experiments investigating the characteristics of the composite materials are reported and discussed in this article. In vitro evaluations confirmed that the Cullet method was suitable for the preparation of the functionally gradient composite implants with higher reliable quality. In vivo experiments permitted evaluation of bonding strength of these composite implants to living bone tissue. Mechanical pull-out tests indicated that the implants bonded to living bone at least as firmly as those by the conventional method, and that the adhesion between the HA-G coating layer and metal substrate was well integrated and strongly maintained in vivo. SEM observations with EDX and a histological study of the interface between the HA-G-Ti composite implants and bone tissue revealed not only that the implants bonded to bone directly without any intervening tissue but that bone ingrowth into the HA-G layer occurred. The HA-G-Ti composite implants demonstrate both biocompatible and osteoconductive characteristics, and may be expected to obtain good and lasting results when applied clinically.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Yamada K,Imamura K,Itoh H,Iwata H,Maruno Sdoi
10.1016/s0142-9612(00)00402-6keywords:
subject
Has Abstractpub_date
2001-08-01 00:00:00pages
2207-14issue
16eissn
0142-9612issn
1878-5905pii
S0142961200004026journal_volume
22pub_type
杂志文章相关文献
BIOMATERIALS文献大全abstract：:Thermosensitive hydrogels based on poly(γ-ethyl-L-glutamate)-poly(ethylene glycol)-poly(γ-ethyl-L-glutamate) triblock copolymers (PELG-PEG-PELG) were prepared for localized and sustained delivery of anticancer drugs. The polypeptide-based hydrogels showed much lower critical gelation concentration than the traditional...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2013.09.064
更新日期：2013-12-01 00:00:00
abstract：:In order to increase the functionality of islets encapsulated in a biohybrid artificial pancreas (BAP), it was proposed that co-encapsulation with insulinotropic agents would improve insulin secretion from islets. To prevent agents from leaking out, conjugation with high-molecular-weight polymers was inevitable. In th...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2004.09.045
更新日期：2005-06-01 00:00:00
abstract：:Phototherapy has drawn increasing attention including the use of nanocarriers with high drug loading capacity and delivery efficacy for target-specific therapy. We have made use of naturally-occurring halloysite nanotubes (HNTs) to build a biomimetic nanocarrier platform for target-specific delivery of phototherapeuti...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2018.10.046
更新日期：2019-01-01 00:00:00
abstract：:The differentiation of odontoblasts is initiated by the organization of differentiating ameloblasts during tooth formation. However, the exact roles of ameloblast-derived factors in odontoblast differentiation have not yet been characterized. We investigated the effects of preameloblast-conditioned medium (PA-CM) on t...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2011.09.007
更新日期：2011-12-01 00:00:00
abstract：:The purpose of this study was to access tissue reactions to the outer prismatic (prism) and the inner nacreous (nacre) layers of the fresh water Margaritifera shell. The materials, in granule form, were implanted into the back muscles and femurs of rats for 1, 2, 4, 8 and 16 weeks. In the back muscles, a foreign body ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(99)00184-2
更新日期：2000-03-01 00:00:00
abstract：:A major obstacle in the survival and efficacy of tissue engineered transplants is inadequate oxygenation, whereby unsupportive oxygen tensions result in significant cellular dysfunction and death within the implant. In a previous report, we developed an innovative oxygen generating biomaterial, termed OxySite, to prov...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2017.03.018
更新日期：2017-06-01 00:00:00
abstract：:A facile and efficient method to immobilize bioactive proteins onto polymeric substrate was established. Testis-specific protease 50 (TSP50) was immobilized on ultrafine biodegradable polymer fibers, i.e., (1) to prepare a propargyl-containing polymer P(LA90-co-MPC10) by introducing propargyl group into a cyclic carbo...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2007.11.008
更新日期：2008-03-01 00:00:00
abstract：:A newly developed bone equivalent hydroxyapatite was derived from veterinary bone (VHAP). Sections of 1 cm of six rabbit mandibles were equally replaced by this VHAP graft. Radiological studies by X-ray were performed pre-operatively, immediately, and 1, 2 and 3 months post-operatively. The graft host-bone interface w...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(94)90211-9
更新日期：1994-06-01 00:00:00
abstract：:Cochlear implant (CI) is a successful device to restore hearing. Despite continuous development, frequency discrimination is poor in CI users due to an anatomical gap between the auditory neurons and CI electrode causing current spread and unspecific neural stimulation. One strategy to close this anatomical gap is gui...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2016.12.020
更新日期：2017-04-01 00:00:00
abstract：:Delivery of polynucleotide-based therapeutics into target cells involves interactions with glycosaminoglycan chains that are located on cell membrane milieu. Mechanisms governing glycosaminoglycan-mediated changes in the nanoparticulate structures of polymer-polynucleotide complexes are unknown, and cannot be fully el...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2017.11.037
更新日期：2018-02-01 00:00:00
abstract：:To prevent wear debris-induced osteolysis and aseptic loosening, cross-linked ultra-high molecular weight polyethylene's (UHMWPE) with improved wear resistance have been developed. Hip simulator studies have demonstrated very low wear rates with these new materials leading to their widespread clinical use. However, th...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(03)00056-5
更新日期：2003-07-01 00:00:00
abstract：:The currently available surgical options to repair the diaphragm are associated with significant risks of defect recurrence, lack of growth potential and restored functionality. A tissue engineered diaphragm has the potential to improve surgical outcomes for patients with congenital or acquired disorders. Here we show...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2015.11.020
更新日期：2016-01-01 00:00:00
abstract：:Vascular smooth muscle cells (VSMCs) isolated from rabbit aorta and immortalised A7r5 cells were cultured on conducting polypyrrole (PPy) substrates and were subjected to a 50muA sinusoidal electrical stimulation at 0.05, 5 and 500 Hz. These substrates were doped with hyaluronic acid and coated with collagen IV follow...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2008.07.052
更新日期：2008-12-01 00:00:00
abstract：:The nanopore size and roughness of nanoporous surface are two critical variables in determining stem cell fate, but little is known about the contribution from each cue individually. To address this gap, we use two-dimensional nanoporous membranes with controlled nanopore size and roughness to culture bone marrow-deri...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2020.120014
更新日期：2020-07-01 00:00:00
abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2010.01.021
更新日期：2010-04-01 00:00:00
abstract：:Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseas...
journal_title：Biomaterials
pub_type： 杂志文章,评审
doi：10.1016/j.biomaterials.2017.09.004
更新日期：2017-11-01 00:00:00
abstract：:Electrical polarization and depolarization processes of the 45S5 type bioactive glass (BG) was studied by a thermally stimulated depolarization current (TSDC) and an complex impedance measurements. The depolarization processes were found to consist of three processes, which were observed as three peaks, P1, P2 and P3,...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2003.12.028
更新日期：2004-09-01 00:00:00
abstract：:In-stent restenosis is one of the most serious modes of failure of cardiovascular stent implant. Although drug-eluting stents have been proven to reduce in-stent restenosis, the nonspecific inhibitory effects of anti-proliferative drugs, such as rapamycin, result in delayed re-endothelialization and fatal late stent t...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2016.11.042
更新日期：2017-02-01 00:00:00
abstract：:It is now well accepted that the initial rapid adsorption of blood proteins to biomaterial surfaces is important in the long-term performance of the implant. Cells that interact with the implant will be reacting to a layer (single or multiple) of adsorbed protein. The parameters of importance in a study of protein ads...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(97)00223-8
更新日期：1998-03-01 00:00:00
abstract：:Patient-derived tumor organoids offer potentially useful models of cancer tissue physiology. Yet, conventional organoid cultures utilize generic matrices that are difficult to tailor for various unique tumor microenvironments. Here, we employ synthetic, enzymatically crosslinked hydrogels to define mechanical and bioc...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2019.119400
更新日期：2019-10-01 00:00:00
abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(93)90197-a
更新日期：1993-10-01 00:00:00
abstract：:Tropoelastin, the polypeptide monomer precursor of elastin, is covalently cross-linked to give stable elastic structures. We show here that elastic biomaterials can be generated from tropoelastin in the absence of the classically accepted cross-linking pathway. Under alkaline conditions tropoelastin proceeds through a...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2008.10.018
更新日期：2009-02-01 00:00:00
abstract：:Two commercially available amalgam alloy powders (one lathe-cut, the other spherical) were characterized in terms of density, surface area, particle size distribution and appearance under the scanning electron microscope. A third, experimental alloy powder, prepared by electrodeposition, was subjected to a similar ana...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(84)90028-0
更新日期：1984-11-01 00:00:00
abstract：:Long-term (8 and 24 month) reactions of the (hypo) dermis of the guinea pig to solid and porous (50 vol%) acrylic implants and four human biopsies from porous subcutaneous acrylic implants were studied light microscopically. The solid implants were encapsulated by dense connective tissue. Mobility was evidenced by the...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(90)90105-y
更新日期：1990-07-01 00:00:00
abstract：:Microspheres comprised of particulate hydroxyapatites dispersed in fibrous collagen matrices were prepared. The procedure involved the droplet formation of hydroxyapatite/collagen mixture emulsified in olive oil, followed by the reconstitution of collagen in the presence of hydroxyapatite particles at 37 degrees C. Va...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(99)00095-2
更新日期：1999-10-01 00:00:00
abstract：:We report here a thermal decomposition approach to the synthesis of water-soluble superparamagnetic manganese ferrite (MnFe(2)O(4)) nanoparticles (NPs) for magnetic resonance (MR) imaging applications. In this approach, tetraethylene glycol was utilized as a coordination and stabilization agent, rendering the NPs wate...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2010.01.055
更新日期：2010-05-01 00:00:00
abstract：:Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/j.biomaterials.2010.02.001
更新日期：2010-05-01 00:00:00
abstract：:Si, Mg-substituted hydroxyapatites, alone and co-substituted, have been prepared to obtain biomaterials having an improved biocompatibility. From FT-IR, XRD and ICP analyses, it was confirmed that single phases of hydroxyapatite substituted by Si alone or co-substituted by Si, Mg. The XRD data indicated the absence of...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/s0142-9612(02)00523-9
更新日期：2003-04-01 00:00:00
abstract：:A silicone-based prepolymer was used as the major component for the fabrication of novel ocular devices. Gentamicin sulphate was used as a probe drug, due to its high aqueous solubility and widespread application. Mechanical properties of films containing the drug before and after gamma sterilization and exposure to h...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(90)90035-o
更新日期：1990-11-01 00:00:00
abstract：:Four commercial hydroxyapatites (both natural and synthetic) were tested to assess transformations of the chemical and crystalline structure following variation of temperature from 20 to 1600 degrees C. The thermal behaviour of hydroxyapatite is relevant for biomedical applications such as plasma spraying of metallic ...
journal_title：Biomaterials
pub_type： 杂志文章
doi：10.1016/0142-9612(93)90146-s
更新日期：1993-05-01 00:00:00
