The effect of the degree of chitosan deacetylation on the efficiency of gene transfection.

abstract：:Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of ...

journal_title：Biomaterials

authors： Deshmukh M,Singh Y,Gunaseelan S,Gao D,Stein S,Sinko PJ

更新日期：2010-09-01 00:00:00

abstract：:Tissue engineering therapies require biomaterials capable of encouraging an angiogenic response. To dissect the influence of different pro-angiogenic stimuli a set of starPEG-heparin hydrogels with varied physicochemical properties was used as a highly efficient reservoir and tunable delivery system for basic fibrobla...

journal_title：Biomaterials

authors： Zieris A,Prokoph S,Levental KR,Welzel PB,Grimmer M,Freudenberg U,Werner C

更新日期：2010-11-01 00:00:00

abstract：:3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel p...

journal_title：Biomaterials

authors： Yang Y,Zhang Q,Xu T,Zhang H,Zhang M,Lu L,Hao Y,Fuh JH,Zhao X

更新日期：2020-12-01 00:00:00

abstract：:The N-terminal 200 amino acid residues of topoisomerase I (TopoN) is highly positive in charge and has DNA binding activity, without DNA sequence and topological specificity. Here, a fusion protein (6 x His-PTD-TopoN) containing a hexahistidine (6 x His) tag, a membrane penetration domain and TopoN (amino acid 3-200) ...

journal_title：Biomaterials

authors： Chen YA,Kuo HC,Chen YM,Huang SY,Liu YR,Lin SC,Yang HL,Chen TY

更新日期：2011-06-01 00:00:00

abstract：:A novel low-pressure radio-frequency plasma treatment protocol was developed to achieve the effective through-thickness surface modification of large porous poly (D,L-lactide) (PDLLA) polymer scaffolds using air or water: ammonia plasma treatments. Polymer films were modified as controls. Scanning electron micrographs...

journal_title：Biomaterials

authors： Safinia L,Datan N,Höhse M,Mantalaris A,Bismarck A

更新日期：2005-12-01 00:00:00

abstract：:In vivo and in vitro degradation of high molecular weight poly(L-lactide) used for internal bone fixation has been investigated. Within 3 months as-polymerized, microporous PLLA (Mv = 6.8-9.5 X 10(5] exhibited a massive strength-loss (sigma b = 68-75 MPa to sigma b = 4 MPa) and decrease of Mv (90-95%). At week 39, the...

journal_title：Biomaterials

authors： Leenslag JW,Pennings AJ,Bos RR,Rozema FR,Boering G

更新日期：1987-07-01 00:00:00

abstract：:Recently, chitosan-gelatin scaffolds have gained much attention in various tissue engineering applications. However, the underlying cell-matrix interactions remain unclear in addition to the scaffold degradation and mechanical characteristics. In this study, we evaluated (i) the degradation kinetics of chitosan and ch...

journal_title：Biomaterials

authors： Huang Y,Onyeri S,Siewe M,Moshfeghian A,Madihally SV

更新日期：2005-12-01 00:00:00

abstract：:One of the major obstacles in drug discovery is the lack of in vitro three-dimensional (3D) models that can capture more complex features of a disease.Here we established a in vitro physiological model of the metabolic syndrome (MS) using cell-assembly technique (CAT), which can assemble cells into designated places t...

journal_title：Biomaterials

authors： Xu M,Wang X,Yan Y,Yao R,Ge Y

更新日期：2010-05-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:Polydimethacrylate resins were prepared by photopolymerization of Bis-GMA, TEGDMA, UDMA or Bis-EMA (4) monomer, initiated by camphoroquinone/N,N-dimethylaminoethyl methacrylate system. The study of physical properties of these resins showed that TEGDMA seems to create the most dense polymer network, which however is t...

journal_title：Biomaterials

authors： Sideridou I,Tserki V,Papanastasiou G

更新日期：2003-02-01 00:00:00

abstract：:We investigated the production of free radicals on a poly(ether-ether-ketone) (PEEK) substrate under ultraviolet (UV) irradiation. The amount of the ketyl radicals produced from the benzophenone (BP) units in the PEEK molecular structure initially increased rapidly and then became almost constant. Our observations rev...

journal_title：Biomaterials

authors： Kyomoto M,Moro T,Yamane S,Hashimoto M,Takatori Y,Ishihara K

更新日期：2013-10-01 00:00:00

abstract：:The objective of this study is to develop a carrier for the controlled release of bone morphogenetic protein-2 (BMP-2) suitable for enhancement of the bone regeneration activity. Hydrogels with different water contents were prepared through glutaraldehyde crosslinking of gelatin with an isoelectric point of 9.0 under ...

journal_title：Biomaterials

authors： Yamamoto M,Takahashi Y,Tabata Y

更新日期：2003-11-01 00:00:00

abstract：:Coralline hydroxyapatite ceramics alone (control) and the ceramics combined with rat marrow cells were implanted subcutaneously in the backs of syngeneic Fischer rats and harvested at 1,2,3,4,6,8 and 24 wk after surgery. None of the control ceramics (without marrow) showed bone formation. However, ceramics combined wi...

journal_title：Biomaterials

authors： Okumura M,Ohgushi H,Tamai S

更新日期：1991-05-01 00:00:00

abstract：:The management of trauma-associated nerve defects is difficult because of the absence of autologous donor motor or sensory nerves. Pre-clinical development and clinical experience has shown that damaged nerves can be surgically repaired using a tubular conduit interposed across the defect. Acceptable patient outcomes ...

journal_title：Biomaterials

authors： Sierpinski P,Garrett J,Ma J,Apel P,Klorig D,Smith T,Koman LA,Atala A,Van Dyke M

更新日期：2008-01-01 00:00:00

abstract：:In this study, the intra-articular tolerability and suitability for local and sustained release of an in situ forming gel composed of an acetyl-capped poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA) copolymer loaded with celecoxib was investigated in horse join...

journal_title：Biomaterials

authors： Petit A,Redout EM,van de Lest CH,de Grauw JC,Müller B,Meyboom R,van Midwoud P,Vermonden T,Hennink WE,René van Weeren P

更新日期：2015-01-01 00:00:00

abstract：:Photolithography is the current workhorse for the microelectronic industry. It has been used extensively for the creation of patterns on two-dimensional surfaces. Various research groups have studied the use of photolithography to pattern surfaces for the alignment of cells. So far, these applications have been limite...

journal_title：Biomaterials

authors： He W,Halberstadt CR,Gonsalves KE

更新日期：2004-05-01 00:00:00

abstract：:Using the recently developed surface modification technique, free amino groups have been introduced onto polyester-type polyurethane (PU) scaffolds. The introduction of these free amino groups increases the surface energy and provides a convenient way to further immobilize bioactive species such as gelatin, collagen o...

journal_title：Biomaterials

authors： Zhu Y,Gao C,He T,Shen J

更新日期：2004-02-01 00:00:00

abstract：:Development of biochips containing living cells for biodetection, drug screening and tissue engineering applications is limited by a lack of reconfigurable material interfaces and actuators. Here we describe a new class of nanostructured magnetizable materials created with a femtosecond laser surface etching technique...

journal_title：Biomaterials

authors： Polte TR,Shen M,Karavitis J,Montoya M,Pendse J,Xia S,Mazur E,Ingber DE

更新日期：2007-06-01 00:00:00

abstract：:We have developed a crosslinked hyaluronic acid (HA) film with DNA incorporated within its structure and have characterized this system for its efficacy in sustained transferring of a vector encoding mouse hyaluronan synthase 2 (Has2). Analysis of the DNA release kinetics indicated that the HA films degraded when trea...

journal_title：Biomaterials

authors： Kim AP,Yellen P,Yun YH,Azeloglu E,Chen W

更新日期：2005-05-01 00:00:00

abstract：:Methyl methacrylate (MMA) is a volatile liquid widely used in the manufacture of acrylic polymers. In modern dentistry, MMA is the mainstream material in denture bases. MMA has been implicated as primary irritant and sensitizer, which can cause allergic eczematous reaction on the oral mucosa as well as skin. To date, ...

journal_title：Biomaterials

authors： Yang HW,Chou LS,Chou MY,Chang YC

更新日期：2003-08-01 00:00:00

abstract：:Tissue-engineered muscle is a viable option for tissue repair, though presently technologies are not developed enough to produce tissue in vitro identical to that in vivo. One important step in generating accurate engineered muscle is to mimic natural muscle architecture. Skeletal muscle is composed of fibrils whose o...

journal_title：Biomaterials

authors： Lam MT,Sim S,Zhu X,Takayama S

更新日期：2006-08-01 00:00:00

abstract：:An appropriate method to bind extracellular matrix (ECM) proteins and growth factors using advanced protein engineering techniques has the potential to enhance cell proliferation and differentiation for tissue regeneration and repair. In this study we developed a method to co-immobilize non-covalently an ECM protein t...

journal_title：Biomaterials

authors： Assal Y,Mie M,Kobatake E

更新日期：2013-04-01 00:00:00

abstract：:Prosthetic heart valves epitomize both the triumphant advance of cardiac surgery in its early days and its stagnation into a retrospective, exclusive first world discipline of late. Fifty-two years after the first diseased heart valve was replaced in a patient, prostheses largely represent the concepts of the 1960s wi...

journal_title：Biomaterials

authors： Zilla P,Brink J,Human P,Bezuidenhout D

更新日期：2008-02-01 00:00:00

abstract：:Drug hepatotoxicity testing requires in vitro hepatocyte culture to maintain the long-term and stable liver specific functions. We developed a drug testing platform based on laminar-flow immediate-overlay hepatocyte sandwich perfusion culture. The immediate-overlay sandwich (collagen-coated porous polymeric membrane a...

journal_title：Biomaterials

authors： Xia L,Ng S,Han R,Tuo X,Xiao G,Leo HL,Cheng T,Yu H

更新日期：2009-10-01 00:00:00

abstract：:Liver diseases can be caused by viral infection, metabolic disorder, alcohol consumption, carcinoma or injury, chronically progressing to end-stage liver disease or rapidly resulting in acute liver failure. In either situation, liver transplantation is most often sought for life saving, which is, however, significantl...

journal_title：Biomaterials

authors： Zhang J,Zhao X,Liang L,Li J,Demirci U,Wang S

更新日期：2018-03-01 00:00:00

abstract：:Implant stability is not only a function of strength but also depends on the fixation established with surrounding tissues [Robertson DM, Pierre L, Chahal R. Preliminary observations of bone ingrowth into porous materials. J Biomed Mater Res 1976;10:335-44]. In the past, such stability was primarily achieved using scr...

journal_title：Biomaterials

authors： Ryan G,Pandit A,Apatsidis DP

更新日期：2006-05-01 00:00:00

abstract：:The use of non-viral nanoparticulate systems for the delivery of therapeutic agents is receiving considerable attention for medical and pharmaceutical applications. This increasing interest results from the fact that these systems can be designed to meet specific physicochemical requirements, and they display low toxi...

journal_title：Biomaterials

authors： Chellat F,Merhi Y,Moreau A,Yahia L

更新日期：2005-12-01 00:00:00

abstract：:The use of a composite graft of bovine trabecular demineralized bone matrix (DBM) and perichondrium has been found a reliable method for in vivo generation of cartilage. In the present study, the mechanism whereby this commercially available matrix increases cartilage formation was investigated. First, the time course...

journal_title：Biomaterials

authors： van Osch GJ,ten Koppel PG,van der Veen SW,Poppe P,Burger EH,Verwoerd-Verhoef HL

更新日期：1999-02-01 00:00:00

abstract：:The development of biohybrid organs (BHO) will benefit from improved membranes regarding transport and cell contacting properties. Here we describe in a first study the development and testing of membranes made of polyacrylonitrile (PAN) and polysulfone (PSU) for the immobilisation of kidney epithelial cells. Comparat...

journal_title：Biomaterials

authors： Fey-Lamprecht F,Groth T,Albrecht W,Paul D,Gross U

更新日期：2000-01-01 00:00:00

abstract：:The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 M phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P...

journal_title：Biomaterials

authors： Wang X,Ma J,Feng Q,Cui F

更新日期：2002-12-01 00:00:00