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Europium-doped gadolinium sulfide nanoparticles as a dual-mode imaging agent for T1-weighted MR and photoluminescence imaging.

Abstract：

:We present a facile synthesis of europium-doped gadolinium sulfide (GdS:Eu(3+)) opto-magnetic nanoparticles (NPs) via sonochemistry. Their photoluminescence and strong paramagnetic properties enable these NPs to be utilized as an in vitro cell imaging and in vivo T(1)-weighted MR imaging probe. The GdS:Eu(3+) NPs have a prominent longitudinal (r(1)) relaxivity value, which is a critical parameter for T(1)-weighted MR imaging. Here, we showed not only their strong positive contrast effect to blood vessels and organs of mice, but also blood half-life and biodistribution including clearance from organs, in order to assess the GdS:Eu(3+) NPs as a competent nanocrystal-based T(1) contrast agent. We further showed confocal images of breast cancer cells containing GdS:Eu(3+) NPs to evaluate as a photoluminescence probe. Dual-mode imaging capability obtained from the GdS:Eu(3+) NPs will allow target-oriented cellular imaging as well as the resulting disease-specific MR imaging.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Jung J,Kim MA,Cho JH,Lee SJ,Yang I,Cho J,Kim SK,Lee C,Park JK

doi

10.1016/j.biomaterials.2012.04.059

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

5865-74

issue

24

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(12)00498-X

journal_volume

33

pub_type

杂志文章

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