Microfabricated microporous membranes reduce the host immune response and prolong the functional lifetime of a closed-loop insulin delivery implant in a type 1 diabetic rat model.

abstract：:Primary rat bone marrow cells were cultured for periods of 8 d on hydroxyapatite discs produced by sintering compressed powder at 1130 degrees C. The disc surfaces were roughened using silicon carbide paper to create three groups of samples (n = 10) of differing surface topography. The culture conditions permitted bot...

journal_title：Biomaterials

authors： Gomi K,Lowenberg B,Shapiro G,Davies JE

更新日期：1993-01-01 00:00:00

abstract：:The phenomenon of light-induced cell detachment is reported. Mouse calvaria-derived, pre-osteoblastic (MC3T3-E1) cells were cultured on a TiO(2) nanodot-coated quartz substrate. After 20 min of UV365 illumination, over 90% of the cells would detach from the surface. Moreover, intact cell sheets could be obtained in th...

journal_title：Biomaterials

authors： Hong Y,Yu M,Weng W,Cheng K,Wang H,Lin J

更新日期：2013-01-01 00:00:00

abstract：:The generation of intracellular reactive oxygen species (ROS) was optically monitored using ROS-sensitive gold nanoprobes in response to an exposure of nanoparticles (NPs). Fluorescent dye-labeled hyaluronic acid was grafted onto the surface of gold nanoparticles (HF-AuNPs) for imaging intracellular ROS. The ultrasens...

journal_title：Biomaterials

authors： Lee K,Lee H,Lee KW,Park TG

更新日期：2011-04-01 00:00:00

abstract：:Retinal pigment epithelial (RPE) cellular morphology and function are vital to the health of the retina. In age-related macular degeneration, RPE dysfunction and changes in Bruch's membrane occur. Thus, a potential cure is a dual-layer biomimetic transplant consisting of a layer of healthy RPE cells cultured on a supp...

journal_title：Biomaterials

authors： Lee CJ,Fishman HA,Bent SF

更新日期：2007-04-01 00:00:00

abstract：:We have prepared unique macroporous and ordered dextran-based hydrogels using a single-step biocatalytic transesterification reaction between dextran and divinyladipate in neat dimethylsulfoxide. These hydrogels show a unimodal distribution of interconnected pores with average diameters from 0.4 to 2.0 microm dependin...

journal_title：Biomaterials

authors： Ferreira L,Gil MH,Cabrita AM,Dordick JS

更新日期：2005-08-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise as a cell source for regenerative medicine yet its culture, maintenance of pluripotency and induction of differentiation remain challenging. Conversely, graphene (G) and graphene oxide (GO) have captured tremendous interests in the fields of materials science, ...

journal_title：Biomaterials

authors： Chen GY,Pang DW,Hwang SM,Tuan HY,Hu YC

更新日期：2012-01-01 00:00:00

abstract：:In mammalian embryos, cortical interneurons travel long distances among complex three-dimensional tissues before integrating into cortical circuits. Several molecular guiding cues involved in this migration process have been identified, but the influence of physical parameters remains poorly understood. In the present...

journal_title：Biomaterials

authors： Leclech C,Renner M,Villard C,Métin C

更新日期：2019-09-01 00:00:00

abstract：:Specific molecularly imprinted polymers (MIPs) for the drug reserpine (RES) using methacrylic acid (MAA) as the functional monomer were developed and characterised for the first time in this study. Evaluation of the various polymers by binding assays indicated that the optimum ratio of functional monomer to template w...

journal_title：Biomaterials

authors： Shi X,Wu A,Qu G,Li R,Zhang D

更新日期：2007-09-01 00:00:00

abstract：:The non-specific interaction between nanoparticles (NPs) and plasma proteins occurs immediately after NPs enter the blood, resulting in the formation of the protein corona that thereafter replaces the original NPs and becomes what the organs and cells really see. Consequently, the in vivo fate of NPs and the biologica...

journal_title：Biomaterials

authors： Peng Q,Zhang S,Yang Q,Zhang T,Wei XQ,Jiang L,Zhang CL,Chen QM,Zhang ZR,Lin YF

更新日期：2013-11-01 00:00:00

abstract：:In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/...

journal_title：Biomaterials

authors： Zhang Z,Zhang M,Chen S,Horbett TA,Ratner BD,Jiang S

更新日期：2008-11-01 00:00:00

abstract：:Temperature-responsive polymers are attractive candidates for applications related to injectable delivery of biologically active therapeutics, such as stem cells. In this study, we evaluate the potential of thermosensitive hydroxybutyl chitosan (HBC) as a biomaterial for the culture of human mesenchymal stem cells (hM...

journal_title：Biomaterials

authors： Dang JM,Sun DD,Shin-Ya Y,Sieber AN,Kostuik JP,Leong KW

更新日期：2006-01-01 00:00:00

abstract：OBJECT:Allogenic human fascia lata used in neurosurgery, as dura mater substitute, can be associated with a risk of viral and bacterial transmission. Chemical and physical procedures, developed to inactivate virus and bacteria, have been applied to fascia lata. The aim of this study consists in the evaluation of the bi...

journal_title：Biomaterials

authors： Dufrane D,Cornu O,Delloye C,Schneider YJ

更新日期：2002-07-01 00:00:00

abstract：:Effective real-time and long-time in vivo imaging for flap perfusion requires bright and stable imaging agents whose emissions can effectively penetrate live tissues without photobleaching. Compared to the standard imaging agent today - intraoperative indocyanine green (ICG), quantum dots (QDs) is a more attractive al...

journal_title：Biomaterials

authors： Feng S,Chen J,Wo Y,Li Y,Chen S,Zhang Y,Zhang W

更新日期：2016-10-01 00:00:00

abstract：:There are a number of drawbacks to incorporating large concentrations of barium sulfate (BaSO4) as the radiopacifier in PMMA-based bone cements for percutaneous vertebroplasty. These include adverse effects on injectability, viscosity profile, setting time, mechanical properties of the cement and bone resorption. We h...

journal_title：Biomaterials

authors： Jacobs E,Saralidze K,Roth AK,de Jong JJ,van den Bergh JP,Lataster A,Brans BT,Knetsch ML,Djordjevic I,Willems PC,Koole LH

更新日期：2016-03-01 00:00:00

abstract：:Glucose oxidase was immobilized into photographic gelatin hardened by chromium(III) sulphate. The enzyme-gelatin mixture was coated on polyester film strips which allowed easy and simple handling during assays. The effect of gelatin and cross-linker concentrations on water content and enzymatic activity was studied. T...

journal_title：Biomaterials

authors： Elçin YM,Akbulut U

更新日期：1992-01-01 00:00:00

abstract：:Polyethylene terephthalate (PET), ethylene-vinyl alcohol copolymer (EVOH) and Nylon 6 in plate form were treated with silane-coupling agents, a titanium alkoxide-alcohol solution and a hot HCl solution to form a thin crystalline titanium oxide layer. When placed in a simulated body fluid with ion concentrations nearly...

journal_title：Biomaterials

authors： Balas F,Kawashita M,Nakamura T,Kokubo T

更新日期：2006-03-01 00:00:00

abstract：:Polystyrene and phenylated polyacrolein microspheres of different diameters, as well as modified cellulose microspheres with different surface charges, were prepared in order to study the size and surface charge effect on their phagocytosis by mouse peritoneal macrophages. It was found that the maximal phagocytosis of...

journal_title：Biomaterials

authors： Tabata Y,Ikada Y

更新日期：1988-07-01 00:00:00

abstract：:Photopolymerizable hydrogels, formed by UV-exposure of photosensitive polymers in the presence of photoinitiators, are widely used materials in tissue engineering research employed for cellular entrapment and patterning. During photopolymerization, the entrapped cells are directly exposed to polymer and photoinitiator...

journal_title：Biomaterials

authors： Fedorovich NE,Oudshoorn MH,van Geemen D,Hennink WE,Alblas J,Dhert WJ

更新日期：2009-01-01 00:00:00

abstract：:We have synthesized and characterized a novel peptide fluorosurfactant polymer (PFSP) modification that facilitates the adhesion and growth of endothelial cells on expanded polytetrafluoroetheylene (ePTFE) vascular graft material. This PFSP consists of a poly(vinyl amine) (PVAm) backbone with integrin binding Arg-Gly-...

journal_title：Biomaterials

authors： Larsen CC,Kligman F,Kottke-Marchant K,Marchant RE

更新日期：2006-10-01 00:00:00

abstract：:Mandibular reconstruction requires functional and aesthetic repair and is further complicated by contamination from oral and skin flora. Antibiotic-releasing porous space maintainers have been developed for the local release of vancomycin and to promote soft tissue attachment. In this study, mandibular defects in six ...

journal_title：Biomaterials

authors： Watson E,Smith BT,Smoak MM,Tatara AM,Shah SR,Pearce HA,Hogan KJ,Shum J,Melville JC,Hanna IA,Demian N,Wenke JC,Bennett GN,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2020-10-01 00:00:00

abstract：:Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chrom...

journal_title：Biomaterials

authors： Puntel A,Maeda A,Golczak M,Gao SQ,Yu G,Palczewski K,Lu ZR

更新日期：2015-03-01 00:00:00

abstract：:The channel of the viral DNA packaging motor allows dsDNA to enter the protein procapsid shell during maturation and to exit during infection. We recently showed that the bacteriophage phi29 DNA packaging motor exercises a one-way traffic property using a channel as a valve for dsDNA translocation. This raises a quest...

journal_title：Biomaterials

authors： Geng J,Fang H,Haque F,Zhang L,Guo P

更新日期：2011-11-01 00:00:00

abstract：:Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to b...

journal_title：Biomaterials

authors： Li L,Yang Q,Zhou Z,Zhong J,Huang Y

更新日期：2014-06-01 00:00:00

abstract：:In vitro protein adsorption, platelet adhesion and activation on new hydrogel surfaces, composed of poly(ethylene oxide) (PEO) and poly(tetramethylene oxide) (PTMO) or poly(dimethyl siloxane) (PDMS), were investigated. By varying PEO length (MW = 2000 or 3400), hydrophobic components (PTMO or PDMS) or polymer topology...

journal_title：Biomaterials

authors： Park JH,Bae YH

更新日期：2002-04-01 00:00:00

abstract：:Liver fibrosis is a major characteristic of liver disease. When the liver is damaged, quiescent hepatic stellate cells (HSCs) transdifferentiate into proliferative myofibroblastic/activated HSCs, which are the main contributors to liver fibrosis. Hence, a strategy for regulating HSC activation is important in the trea...

journal_title：Biomaterials

authors： Wang S,Kim J,Lee C,Oh D,Han J,Kim TJ,Kim SW,Seo YS,Oh SH,Jung Y

更新日期：2019-10-01 00:00:00

abstract：:When subjected to a monotonically increasing deformation state, the mechanical behavior of UHMWPE is characterized by a linear elastic response followed by distributed yielding and strain hardening at large deformations. During the unloading phases of an applied cyclic deformation process, the response is characterize...

journal_title：Biomaterials

authors： Bergström JS,Kurtz SM,Rimnac CM,Edidin AA

更新日期：2002-06-01 00:00:00

abstract：:Our focus was to develop a three-dimensional (3D) human dynamic in vitro tissue model that mimics the natural microenvironment of the small intestine. We co-cultured human Caco-2 cells with primary-isolated human microvascular endothelial cells (hMECs) on decellularized porcine jejunal segments within a custom-made dy...

journal_title：Biomaterials

authors： Pusch J,Votteler M,Göhler S,Engl J,Hampel M,Walles H,Schenke-Layland K

更新日期：2011-10-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) with four reprogramming factors (Oct-4/Sox2/Klf-4/c-Myc) have been shown to differentiate into hepatic lineages. However, it was unclear whether obviation of the c-Myc oncogene in iPSCs affected hepatic differentiation or inhibited in vivo tumor formation. In this study, we demon...

journal_title：Biomaterials

authors： Li HY,Chien Y,Chen YJ,Chen SF,Chang YL,Chiang CH,Jeng SY,Chang CM,Wang ML,Chen LK,Hung SI,Huo TI,Lee SD,Chiou SH

更新日期：2011-09-01 00:00:00

abstract：:Hydrophobically derivatized hyperbranched polyglycerol (HPG)-polyethylene glycol (PEG) polymers bearing stearoyl chains (HPG-C18-PEG) were originally developed as human serum albumin substitutes and further as a unimolecular drug delivery system. In view of these in vivo applications and the potential for membrane int...

journal_title：Biomaterials

authors： Liu Z,Janzen J,Brooks DE

更新日期：2010-04-01 00:00:00

abstract：:Coralline hydroxyapatite ceramics alone (control) and the ceramics combined with rat marrow cells were implanted subcutaneously in the backs of syngeneic Fischer rats and harvested at 1,2,3,4,6,8 and 24 wk after surgery. None of the control ceramics (without marrow) showed bone formation. However, ceramics combined wi...

journal_title：Biomaterials

authors： Okumura M,Ohgushi H,Tamai S

更新日期：1991-05-01 00:00:00