Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles.

abstract：:Ectopic expression of heme oxygenase-1 (HO-1) in ischemic tissue protects the tissue from apoptosis and necrosis and promotes angiogenesis. However, apoptosis and necrosis will decrease HO-1 gene transfection efficacy. We hypothesized that fibroblast growth factor-2 (FGF2) would attenuate ischemic damage during the in...

journal_title：Biomaterials

authors： Bhang SH,Kim JH,Yang HS,La WG,Lee TJ,Sun AY,Kim GH,Lee M,Kim BS

更新日期：2009-10-01 00:00:00

abstract：:Knee arthroplasty has reached a high degree of reliability. Many of the remaining long-term loosening cases are due to the polyethylene wear debris. The introduction of the alumina ceramic to polyethylene bearing couple had been a promising means for its reduction. The discussion of its applications in total knee repl...

journal_title：Biomaterials

authors： Heimke G,Leyen S,Willmann G

更新日期：2002-04-01 00:00:00

abstract：:Endocytosis is a fundamental biological process and is also the key mechanism for drug and non-viral gene delivery. The importance of topographical cues in modulating cell behaviors has become increasingly evident, but the influence of topography on endocytosis has however only been sparsely studied. We hypothesize th...

journal_title：Biomaterials

authors： Teo BK,Goh SH,Kustandi TS,Loh WW,Low HY,Yim EK

更新日期：2011-12-01 00:00:00

abstract：:Astroglial cell survival and ion channel activity are relevant molecular targets for the mechanistic study of neural cell interactions with biomaterials and/or electronic interfaces. Astrogliosis is the most typical reaction to in vivo brain implants and needs to be avoided by developing biomaterials that preserve ast...

journal_title：Biomaterials

authors： Benfenati V,Toffanin S,Capelli R,Camassa LM,Ferroni S,Kaplan DL,Omenetto FG,Muccini M,Zamboni R

更新日期：2010-11-01 00:00:00

abstract：:In the present work, we designed and synthesized a novel mono-guanidine heterolipid (MGH) and confirmed its structure by NMR and ESI-MS. The MGH was used as cationic lipid in developing etoposide loaded cationic self-microemulsifying drug delivery system (ECS) intended to be delivered by intratumoral route. The ECS ex...

journal_title：Biomaterials

authors： Shete H,Sable S,Tidke P,Selkar N,Pawar Y,Chakraborty A,De A,Vanage G,Patravale V

更新日期：2015-07-01 00:00:00

abstract：:This work describes the use of aqueous two-phase systems to print cell-containing contractile collagen microdroplets. The fully aqueous conditions enable convenient formation of sub-microliter 'microgels' that are much smaller than otherwise possible to fabricate while maintaining high cell viability. The produced mic...

journal_title：Biomaterials

authors： Moraes C,Simon AB,Putnam AJ,Takayama S

更新日期：2013-12-01 00:00:00

abstract：:This experimental investigation aims at revealing the mechanical behaviour and failure pattern of direct fibre-reinforced resin-bonded dental bridge with various designs. To evaluate the overall effects of some newly developed dental materials, in the experiment, genuine composite dental bridge specimens are prepared ...

journal_title：Biomaterials

authors： Li W,Swain MV,Li Q,Ironside J,Steven GP

更新日期：2004-09-01 00:00:00

abstract：:Seven nominally identical samples of Na-free carbonate apatite (CO(3)Ap) were prepared by reaction of CaHPO(4) with ammonium carbonate solution at 70 degrees C over 3 days. They were studied by chemical analysis, Rietveld analysis of powder X-ray diffraction (XRD) data, Ca/P ratio determinations (quantitative phase an...

journal_title：Biomaterials

authors： Wilson RM,Dowker SE,Elliott JC

更新日期：2006-09-01 00:00:00

abstract：:The introduction of vaccines is regarded as one of the most successful medical interventions to date. However, there is a clear need for the development of new vaccines for diseases which require the induction of a potent cellular immune response. Advancements in the field of vaccine research have resulted in a move a...

journal_title：Biomaterials

authors： Moran HBT,Turley JL,Andersson M,Lavelle EC

更新日期：2018-11-01 00:00:00

abstract：:Human (h) pluripotent stem cells (PSC) such as embryonic stem cells (ESC) can be directed into cardiomyocytes (CMs), representing a potential unlimited cell source for disease modeling, cardiotoxicity screening and myocardial repair. Although the electrophysiology of single hESC-CMs is now better defined, their multi-...

journal_title：Biomaterials

authors： Wang J,Chen A,Lieu DK,Karakikes I,Chen G,Keung W,Chan CW,Hajjar RJ,Costa KD,Khine M,Li RA

更新日期：2013-11-01 00:00:00

abstract：:Realization of systems able to both recruit cells and influence their fate (affecting their processes) represents a new approach for tissue regeneration. We investigated the potency of gene activated matrix (GAM) and implemented the GAM strategy in order to achieve a control of gene expression, as well as a specific c...

journal_title：Biomaterials

authors： Orsi S,De Capua A,Guarnieri D,Marasco D,Netti PA

更新日期：2010-01-01 00:00:00

abstract：:Optimal nano-sized drug carrier requires long blood circulation, selective extravasation, and efficient cell uptake. Here we develop a charge-convertible nanoplatform based on Pt(IV) prodrug loaded NaYF4:Yb,Tm upconversion nanoparticles (UCNs), followed by coating a layer of PEG-PAH-DMMA polymer (UCNs-Pt(IV)@PEG-PAH-D...

journal_title：Biomaterials

authors： Xu J,Kuang Y,Lv R,Yang P,Li C,Bi H,Liu B,Yang D,Dai Y,Gai S,He F,Xing B,Lin J

更新日期：2017-06-01 00:00:00

abstract：:Here, we report the safety, tumor accumulation and potential of polyethylene glycol-grafted graphene oxide (pGO) as a multimodal nanocarrier of photosensitizers and synergistic anticancer agents. First, both graphene oxide (GO) and pGO were synthesized, and their in vitro and in vivo toxicities were tested. When 80 mg...

journal_title：Biomaterials

authors： Miao W,Shim G,Lee S,Lee S,Choe YS,Oh YK

更新日期：2013-04-01 00:00:00

abstract：:One of the key challenges for neural tissue engineering is to exploit supporting materials with robust functionalities not only to govern cell-specific behaviors, but also to form functional neural network. The unique electrical and mechanical properties of graphene imply it as a promising candidate for neural interfa...

journal_title：Biomaterials

authors： Tang M,Song Q,Li N,Jiang Z,Huang R,Cheng G

更新日期：2013-09-01 00:00:00

abstract：:The dynamic regulation of integrin-binding peptides is crucial for chondrogenic differentiation. Here, we revealed the feasibility for flexible modification of RGD by embedding a large molecular weight and slightly charged (isoelectric point, 6-6.25) RGD-chimeric protein (CBD-RGD) with cellulose-binding domain (CBD) i...

journal_title：Biomaterials

authors： Chang JC,Hsu SH,Chen DC

更新日期：2009-10-01 00:00:00

abstract：:Engineered stem cell (SC)-based therapy holds enormous promise for treating the incurable brain cancer glioblastoma (GBM). Retaining the cytotoxic SCs in the surgical cavity after GBM resection is one of the greatest challenges to this approach. Here, we describe a biocompatible electrospun nanofibrous scaffold (bENS)...

journal_title：Biomaterials

authors： Bagó JR,Pegna GJ,Okolie O,Mohiti-Asli M,Loboa EG,Hingtgen SD

更新日期：2016-06-01 00:00:00

abstract：:Angiogenesis is critical in the early stage of reparative processes and tissue regeneration, but the persistence of a vascular network may interfere with later transformation/maturation in naturally avascular tissues such as articular cartilage. Our supposition is that the timed delivery of an anti-angiogenic factor i...

journal_title：Biomaterials

authors： Sun XD,Jeng L,Bolliet C,Olsen BR,Spector M

更新日期：2009-02-01 00:00:00

abstract：:Lacking a blood supply and having a low cellular density, articular cartilage has a minimal ability for self-repair. Therefore, wide-ranging cartilage damage rarely resolves spontaneously. Cartilage damage is typically treated by chondrocyte transplantation, mosaicplasty or microfracture. Recent advances in tissue eng...

journal_title：Biomaterials

authors： Ebihara G,Sato M,Yamato M,Mitani G,Kutsuna T,Nagai T,Ito S,Ukai T,Kobayashi M,Kokubo M,Okano T,Mochida J

更新日期：2012-05-01 00:00:00

abstract：:The ultra-short pulse microwave could excite to the strong thermoacoustic (TA) shock wave and deeply penetrate in the biological tissues. Based on this, we developed a novel deep-seated tumor therapy modality with mitochondria-targeting single wall carbon nanotubes (SWNTs) as microwave absorbing agents, which act effi...

journal_title：Biomaterials

authors： Wen L,Ding W,Yang S,Xing D

更新日期：2016-01-01 00:00:00

abstract：:Construction of bio-mimetic well-organized three-dimensional (3D) tissue with various cells in vitro is one of the ultimate goals of tissue engineering. In particular, fabrication of vasculature in 3D tissue is one of the most important tasks in tissue engineering, because a vascular network is indispensable for almos...

journal_title：Biomaterials

authors： Muraoka M,Shimizu T,Itoga K,Takahashi H,Okano T

更新日期：2013-01-01 00:00:00

abstract：:Upconversion fluorescent nanoparticles are becoming more widely used as imaging contrast agents, owing to their high resolution and penetration depth, and avoidance of tissue auto-fluorescence and photodamage to cells. Here, we synthesized upconversion fluorescent crystals from rare-earth Yb3+ and Ho3+ co-doped fluora...

journal_title：Biomaterials

authors： Hu X,Zhu J,Li X,Zhang X,Meng Q,Yuan L,Zhang J,Fu X,Duan X,Chen H,Ao Y

更新日期：2015-06-01 00:00:00

abstract：:Highly oriented hydroxyapatite coatings (HACs) were obtained on titanium substrates through a radio-frequency thermal plasma spraying (TPS) method. XRD patterns showed that the HACs had crystallites with [001] preferred orientation vertical to the coating's surface. XRD results also indicated that tetracalcium phospha...

journal_title：Biomaterials

authors： Inagaki M,Kameyama T

更新日期：2007-07-01 00:00:00

abstract：:Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

journal_title：Biomaterials

authors： DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

更新日期：2020-11-01 00:00:00

abstract：:Microcontact printed polymeric substrates were evaluated for their ability to control Schwann cell attachment and direct proliferation, as Schwann cell guidance is a crucial factor in directing peripheral nerve regeneration. Elastomeric stamps of poly(dimethylsiloxane) were "inked" with laminin, a permissive protein f...

journal_title：Biomaterials

authors： Schmalenberg KE,Uhrich KE

更新日期：2005-04-01 00:00:00

abstract：:A new implant surface has been developed with the purpose of avoiding as much stress shielding as possible, and thus prolong the prosthesis lifespan. The aim of this study was to investigate the in vitro effect of this new ultra-high roughness and dense Titanium (Ti) surface (PG60, Ra = 74 microm) in comparison with m...

journal_title：Biomaterials

authors： Borsari V,Giavaresi G,Fini M,Torricelli P,Tschon M,Chiesa R,Chiusoli L,Salito A,Volpert A,Giardino R

更新日期：2005-08-01 00:00:00

abstract：:The application of non-viral gene delivery vectors is often accompanied with the poor correlation between transfection efficiency and the safety profiles of vectors. Vectors with high transfection efficiencies often suffer from high toxicities, making it unlikely to improve their efficiencies by increasing the DNA dos...

journal_title：Biomaterials

authors： Zheng N,Yin L,Song Z,Ma L,Tang H,Gabrielson NP,Lu H,Cheng J

更新日期：2014-01-01 00:00:00

abstract：:Ocular surface diseases including conjunctival disorders are multifactorial progressive conditions that can severely affect vision and quality of life. In recent years, stem cell therapies based on conjunctival stem cells (CjSCs) have become a potential solution for treating ocular surface diseases. However, neither a...

journal_title：Biomaterials

authors： Zhong Z,Deng X,Wang P,Yu C,Kiratitanaporn W,Wu X,Schimelman J,Tang M,Balayan A,Yao E,Tian J,Chen L,Zhang K,Chen S

更新日期：2021-01-01 00:00:00

abstract：:This article reports a novel preparation method of poly(ethylene glycol) (PEG)-polystyrene (PST) amphiphilic block copolymers with well-defined block lengths by using photopolymerization of an iniferter, benzyl N,N-diethyldithiocarbamate. PEG macroiniferters, which were prepared by end-capping of PEG monomethyl ethers...

journal_title：Biomaterials

authors： Nakayama Y,Miyamura M,Hirano Y,Goto K,Matsuda T

更新日期：1999-05-01 00:00:00

abstract：:Myotube formation is crucial to restoring muscular functions, and biomaterials that enhance the myoblast differentiation into myotubes are highly desirable for muscular repair. Here, we report the synthesis of electroactive, ductile, and degradable copolymers and their application in enhancing the differentiation of m...

journal_title：Biomaterials

authors： Xie M,Wang L,Guo B,Wang Z,Chen YE,Ma PX

更新日期：2015-12-01 00:00:00

abstract：:The ability to influence the direction of polymerization of a self-assembling biomolecular system has the potential to generate materials with extremely high anisotropy. In biological systems where highly-oriented cellular populations give rise to aligned and often load-bearing tissue such organized molecular scaffold...

journal_title：Biomaterials

authors： Saeidi N,Sander EA,Ruberti JW

更新日期：2009-12-01 00:00:00