Co-assembling peptides as defined matrices for endothelial cells.

abstract：:Nanoparticles formulated from biodegradable polymers such as poly(lactic acid) (PLA) and poly(lactide-co-glycolide) (PLGA) are being extensively investigated as non-viral gene delivery systems due to their controlled release characteristics and biocompatibility. PLGA nanoparticles for DNA delivery are mainly formulate...

journal_title：Biomaterials

authors： Ravi Kumar MN,Bakowsky U,Lehr CM

更新日期：2004-05-01 00:00:00

abstract：:Immune response testing of biomaterials is an essential component of biocompatibility assessment, particularly when the materials of interest are used to design bioresorbable scaffolds with the potential to promote in situ regeneration. Current trends in immune response testing of biomaterials typically examine few el...

journal_title：Biomaterials

authors： Smith MJ,White KL Jr,Smith DC,Bowlin GL

更新日期：2009-01-01 00:00:00

abstract：:Integrins represent the primary mechanism of cell-extracellular matrix interactions and control cell morphology, proliferation, and differentiation. We have previously shown that substrate-dependent modulation of adsorbed fibronectin (Fn) conformation alters alpha5beta1 integrin binding to Fn and directs C2C12 myoblas...

journal_title：Biomaterials

authors： Stephansson SN,Byers BA,García AJ

更新日期：2002-06-01 00:00:00

abstract：:Understanding how engineered tissue scaffold architecture affects cell morphology, metabolism, phenotypic expression, as well as predicting material mechanical behavior has recently received increased attention. In the present study, an image-based analysis approach that provides an automated tool to characterize engi...

journal_title：Biomaterials

authors： D'Amore A,Stella JA,Wagner WR,Sacks MS

更新日期：2010-07-01 00:00:00

abstract：:We describe the design of original nanocarriers that allows for ultrahigh chromophore loading while maintaining the photo-activity of each individual molecule. They consist in shells of charged biocompatible polymers grafted on gold nanospheres. The self-organization of extended polymer chains results from repulsive c...

journal_title：Biomaterials

authors： Navarro JR,Lerouge F,Cepraga C,Micouin G,Favier A,Chateau D,Charreyre MT,Lanoë PH,Monnereau C,Chaput F,Marotte S,Leverrier Y,Marvel J,Kamada K,Andraud C,Baldeck PL,Parola S

更新日期：2013-11-01 00:00:00

abstract：:A tissue-engineered substitute that facilitates large-volume regeneration of the subcutaneous adipose tissue layer is needed for reconstructive plastic surgery. Towards this goal, we describe the in vitro culture of primary human adipose-derived stem cells (ASC) seeded into placental decellular matrix (PDM) and cross-...

journal_title：Biomaterials

authors： Flynn LE,Prestwich GD,Semple JL,Woodhouse KA

更新日期：2008-04-01 00:00:00

abstract：:Safety and high efficacy of vectors are essential requirements for gene therapy. To address these challenges, poly(carboxy betaine methacrylate ethyl ester)-poly(carboxy betaine methacrylate) (PCBMAEE-PCBMA) diblock copolymers were synthesized to form core-shell vector for gene delivery. The hydrophobic PCBMAEE segmen...

journal_title：Biomaterials

authors： Zhang J,Wang Z,Lin W,Chen S

更新日期：2014-09-01 00:00:00

abstract：:Antigen-specific treatments are highly desirable for autoimmune diseases in contrast to treatments which induce systemic immunosuppression. A novel antigen-specific therapy has been developed which, when administered semi-therapeutically, is highly efficacious in the treatment of the mouse model for multiple sclerosis...

journal_title：Biomaterials

authors： Cho JJ,Stewart JM,Drashansky TT,Brusko MA,Zuniga AN,Lorentsen KJ,Keselowsky BG,Avram D

更新日期：2017-10-01 00:00:00

abstract：:The peripheral nerve contains three barriers which include the blood-nerve barrier consisting of endoneurial vessels and the perineurium as well as autotypic junctions in Schwann cells. The perineurium prevents diffusion of perineurally injected drugs that can be used for selective regional pain control. It is compose...

journal_title：Biomaterials

authors： Yang S,Krug SM,Heitmann J,Hu L,Reinhold AK,Sauer S,Bosten J,Sommer C,Fromm M,Brack A,Rittner HL

更新日期：2016-03-01 00:00:00

abstract：:Nanoparticle-induced autophagy is crucial for its metabolism, cytotoxicity and therapy potency, but little is known about how the host immune system would respond to it. In this study, we demonstrated that two clinically used superparamagnetic iron oxide nanoparticles (SPIONs) specifically induced macrophage autophagy...

journal_title：Biomaterials

authors： Jin R,Liu L,Zhu W,Li D,Yang L,Duan J,Cai Z,Nie Y,Zhang Y,Gong Q,Song B,Wen L,Anderson JM,Ai H

更新日期：2019-05-01 00:00:00

abstract：:Combinations of an alkali-containing calcium phosphate-like rhenanite, sodium whitlockite or calcium potassium phosphate and a chloride-containing calcium phosphate-like spodiosite or chloroapatite with or without additions of other calcium phosphates like monocalcium phosphate monohydrate, dicalcium phosphate or dica...

journal_title：Biomaterials

authors： Bermúdez O,Boltong MG,Driessens FC,Ginebra MP,Fernández E,Planell JA

更新日期：1994-10-01 00:00:00

abstract：:Cell labeling using magnetic nanoparticles is an increasingly used approach in noninvasive behavior tracking, in vitro separation of cancer stem cells (CSCs), and CSC-based research in cancer therapy. However, the impact of magnetic labeling on the biological properties of targeted CSCs, such as self-renewal, prolifer...

journal_title：Biomaterials

authors： Wang X,Wei F,Liu A,Wang L,Wang JC,Ren L,Liu W,Tu Q,Li L,Wang J

更新日期：2012-05-01 00:00:00

abstract：:Hydroxyapatite (HA) in 25%, 50% and 75% w/w fractions was incorporated into chitin solutions and processed into air- and freeze-dried materials. These HA-chitin materials were exposed to cell cultures and implanted into the intramusculature of a rat model. The HA-chitin materials were found to be non-cytotoxic and deg...

journal_title：Biomaterials

authors： Ge Z,Baguenard S,Lim LY,Wee A,Khor E

更新日期：2004-03-01 00:00:00

abstract：:It is known that the organic molecules can provide an effective means to manipulate the surface properties of the biodegradable ceramic. There are two ways to modify the surface of the biodegradable ceramic by organic molecules. The first one is through surface adsorption but organic molecules will easily be washed ou...

journal_title：Biomaterials

authors： Dong GC,Sun JS,Yao CH,Jiang GJ,Huang CW,Lin FH

更新日期：2001-12-01 00:00:00

abstract：:Nanofiber scaffold-mediated delivery of small-interfering RNA (siRNA) holds great potential in regenerative medicine by providing biomimicking topographical signals and enhanced gene silencing effects to seeded cells. While the delivery of naked siRNA was demonstrated previously using poly (ε-caprolactone) (PCL) nanof...

journal_title：Biomaterials

authors： Rujitanaroj PO,Wang YC,Wang J,Chew SY

更新日期：2011-09-01 00:00:00

abstract：:Right femoral, cortical bone osteotomies of 42 rabbits were fixed with fibrillated, self-reinforced (SR) poly-L-lactide (PLLA) rods, 4.5 mm in diameter. Follow-up times were from 3 to 48 wk. None of the rods broke during this period. There was one non-union at three weeks and one non-union at 12 weeks. Radiographic, h...

journal_title：Biomaterials

authors： Manninen MJ,Pohjonen T

更新日期：1993-01-01 00:00:00

abstract：:Photopolymerized hydrogels are being investigated for a number of tissue engineering applications because of the ability to form these materials in situ in a minimally invasive manner such as by injection. In addition, hydrogels, three-dimensional networks of hydrophilic polymers that are able to swell large amounts o...

journal_title：Biomaterials

authors： Nguyen KT,West JL

更新日期：2002-11-01 00:00:00

abstract：:Development of high selectivity, accurate targeted and noninvasive fluorescent probe for monitoring specific enzyme activity associated with the tumor is urgent needed for early diagnosis of cancer and clinical fluorescence interventional resection guidance treatment. Owing to the invasion of malignant tumor cells, tu...

journal_title：Biomaterials

authors： Li H,Yao Q,Xu F,Xu N,Duan R,Long S,Fan J,Du J,Wang J,Peng X

更新日期：2018-10-01 00:00:00

abstract：:Materials for orthopaedic implants can fail for several combined reasons: corrosion, fatigue and wear for metals, wear and creep for polymers, fracture for ceramics. Some typical cases are analysed and it is demonstrated that ion implantation improves metals and polymers used for joint prosthesis. Implantations of nit...

journal_title：Biomaterials

authors： Rieu J,Pichat A,Rabbe LM,Chabrol C,Robelet M

更新日期：1990-07-01 00:00:00

abstract：:Biological heart prostheses present medium and long-term problems, owing to progressive deterioration and calcification of the tissue. To study the latter problem, we compared the effectiveness of anticalcification treatments in calf pericardium samples implanted into female Wistar rats after the following procedures:...

journal_title：Biomaterials

authors： Jorge-Herrero E,Gutiérrez MP,Castillo-Olivares JL

更新日期：1991-03-01 00:00:00

abstract：:This work describes the use of aqueous two-phase systems to print cell-containing contractile collagen microdroplets. The fully aqueous conditions enable convenient formation of sub-microliter 'microgels' that are much smaller than otherwise possible to fabricate while maintaining high cell viability. The produced mic...

journal_title：Biomaterials

authors： Moraes C,Simon AB,Putnam AJ,Takayama S

更新日期：2013-12-01 00:00:00

abstract：:We studied non-implanted ultra-high molecular weight polyethylene (UHMWPE) knee components, that were gamma-sterilized in air and shelf-aged during 6 and 7 years, to explore fracture mechanisms in the degraded material. Prior to the fractography study, we assessed degradation through FTIR and optical density measureme...

journal_title：Biomaterials

authors： Puértolas JA,Larrea A,Gómez-Barrena E

更新日期：2001-08-01 00:00:00

abstract：:Astroglial cell survival and ion channel activity are relevant molecular targets for the mechanistic study of neural cell interactions with biomaterials and/or electronic interfaces. Astrogliosis is the most typical reaction to in vivo brain implants and needs to be avoided by developing biomaterials that preserve ast...

journal_title：Biomaterials

authors： Benfenati V,Toffanin S,Capelli R,Camassa LM,Ferroni S,Kaplan DL,Omenetto FG,Muccini M,Zamboni R

更新日期：2010-11-01 00:00:00

abstract：:The aim of this in vitro study was to evaluate the antimicrobial activity, the substantivity, and surface effects of the inclusion compound tetracycline: beta-cyclodextrin on bovine roots. The antimicrobial activity was assessed by dentine slabs which had been immersed in the inclusion complex in concentrations 8.0%, ...

journal_title：Biomaterials

authors： Pataro AL,Franco CF,Santos VR,Cortés ME,Sinisterra RD

更新日期：2003-03-01 00:00:00

abstract：:Based on the hypothesis that bone cements cause changes in the production of transforming growth factor-beta 1 (TGF-beta1) by bone cells, the effects of four acrylic bone cements (Sulfix-60, CMW 1, CMW 2 and CMW 3) were examined using the osteoblast-like cell line MG63. The extracts in MEM of the cements were tested, ...

journal_title：Biomaterials

authors： Cenni E,Granchi D,Ciapetti G,Savarino L,Corradini A

更新日期：2002-01-01 00:00:00

abstract：:Cationic nanoparticles are a promising class of transfection agents for oligonucleotide and gene delivery, but vary greatly in their effectiveness and cytotoxicity. Recently, we developed a new class of cationic transfection agents based on cationic shell-crosslinked knedel-like nanoparticles (cSCKs) that efficiently ...

journal_title：Biomaterials

authors： Zhang K,Fang H,Wang Z,Li Z,Taylor JS,Wooley KL

更新日期：2010-03-01 00:00:00

abstract：:Implant surface topography influences osteoblastic proliferation, differentiation and extracellular matrix protein expressions. Studies on preliminary interactions of osteoblast-like cells on implant interface through in vitro systems, can give lucid insights to osseo-integrative efficacies of when in vivo implants. I...

journal_title：Biomaterials

authors： Jayaraman M,Meyer U,Bühner M,Joos U,Wiesmann HP

更新日期：2004-02-01 00:00:00

abstract：:Bioencapsulation involves the envelopment of tissues or biological active substances in semipermeable membranes. Bioencapsulation has been shown to be efficacious in mimicking the cell's natural environment and thereby improves the efficiency of production of different metabolites and therapeutic agents. The field of ...

journal_title：Biomaterials

authors： de Vos P,Bucko M,Gemeiner P,Navrátil M,Svitel J,Faas M,Strand BL,Skjak-Braek G,Morch YA,Vikartovská A,Lacík I,Kolláriková G,Orive G,Poncelet D,Pedraz JL,Ansorge-Schumacher MB

更新日期：2009-05-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:Sintered bovine cancellous bone exhibited excellent biocompatiblity, high porosity and have an interconnecting porous structure allowing for bone ingrowth. However, the main mineral constitution of sintered bovine bone-hydroxyapatite (Ca10(PO4)6(OH)2, HAP) seems to be too stable in vivo. For improving its bioactivity,...

journal_title：Biomaterials

authors： Lin FH,Liao CJ,Chen KS,Sun JS

更新日期：1999-03-01 00:00:00