Abstract：
:A series of polymer and copolymer networks with varying hydrophilicity and distribution of the hydrophilic groups was synthesized and biologically tested with monolayer culture of human chondrocytes in vitro. Cell viability (MTT), proliferation (BrdU incorporation) and aggrecan expression (PG ELISA) were quantified at 7 and 14 days from seeding. Both assays (MTT and BrdU) showed complementary results that are consistent with positive cellular adhesion on the material. When human chondrocytes were cultured on polymer substrates in which the hydrophilic groups were homogeneously distributed, hydrophobic substrates showed higher values in all the biological parameters analysed. Adhesion, proliferation and viability decreased monotonously with the content of hydrophilic groups in the polymer chain. However poly(ethyl acrylate-co-hydroxyethyl methacrylate) copolymers, in which hydrophilic and hydrophobic nano-domains alternate as phase-separated domains, showed better results than the corresponding homopolymers.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Pérez Olmedilla M,Garcia-Giralt N,Pradas MM,Ruiz PB,Gómez Ribelles JL,Palou EC,García JCdoi
10.1016/j.biomaterials.2005.07.030keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
1003-12issue
7eissn
0142-9612issn
1878-5905pii
S0142-9612(05)00696-4journal_volume
27pub_type
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