Abstract:
:Cerium oxide nanoparticles (nanoceria) are promising materials for intracellular oxygen free radical scavenging providing a potential therapy for reactive oxygen species (ROS)-mediated inflammatory processes. In this study rhombohedral-shaped nanoceria were synthesized by flame spray pyrolysis with tuneable particle diameters between 3 and 94 nm by changing the liquid precursor flow rate. Monocytes and macrophages are major players in inflammatory processes as their production of ROS species has important downstream effects on cell signalling. Therefore, this study examined the ability of the nanoceria to be internalised by the human monocytic cell line, U937, and scavenge intracellular ROS. U937 cells activated in the presence of phorbol 12-myristate 13-acetate (PMA) were found to be more responsive to the nanoceria than U937 cells, which may not be surprising given the role of monocyte/macrophages in phagocytosing foreign material. The smaller particles were found to contain more crystal lattice defects with which to scavenge ROS, however a greater proportion of both the U937 and activated U937 cell populations responded to the larger particles. Hence all nanoceria particle sizes examined in this study were equally effective in scavenging intracellular ROS.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Lord MS,Jung M,Teoh WY,Gunawan C,Vassie JA,Amal R,Whitelock JMdoi
10.1016/j.biomaterials.2012.07.024subject
Has Abstractpub_date
2012-11-01 00:00:00pages
7915-24issue
31eissn
0142-9612issn
1878-5905pii
S0142-9612(12)00806-Xjournal_volume
33pub_type
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