Transection of peripheral nerves, bridging strategies and effect evaluation.

abstract：:Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood-brain and blood-tumor barriers that limit the delivery of imaging and therapeutic agents from the systemic circulation to tumors. Thus, improved strategies for brain tumor visualization and ta...

journal_title：Biomaterials

authors： Wu JB,Shi C,Chu GC,Xu Q,Zhang Y,Li Q,Yu JS,Zhau HE,Chung LW

更新日期：2015-10-01 00:00:00

abstract：:Biomaterials can potentially influence stem and progenitor cell proliferation and differentiation in both a positive and a negative way. Herein, we report on the expansion and differentiation of rat embryonic (E17) liver (RLC-18) cells on new bioactive membrane made of PEEK-WC-PU, whose surface was grafted with nitrog...

journal_title：Biomaterials

authors： Pavlica S,Piscioneri A,Peinemann F,Keller M,Milosevic J,Staeudte A,Heilmann A,Schulz-Siegmund M,Laera S,Favia P,De Bartolo L,Bader A

更新日期：2009-11-01 00:00:00

abstract：:We present here an easy method to modify the surface chemistry of polymeric microcapsules of perfluorooctyl bromide used as ultrasound contrast agents (UCAs). Capsules were obtained by a solvent emulsification-evaporation process with phospholipids incorporated in the organic phase before emulsification. Several phosp...

journal_title：Biomaterials

authors： Díaz-López R,Tsapis N,Libong D,Chaminade P,Connan C,Chehimi MM,Berti R,Taulier N,Urbach W,Nicolas V,Fattal E

更新日期：2009-03-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:When subjected to a monotonically increasing deformation state, the mechanical behavior of UHMWPE is characterized by a linear elastic response followed by distributed yielding and strain hardening at large deformations. During the unloading phases of an applied cyclic deformation process, the response is characterize...

journal_title：Biomaterials

authors： Bergström JS,Kurtz SM,Rimnac CM,Edidin AA

更新日期：2002-06-01 00:00:00

abstract：:Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. To address this issue, we introduce here a novel technique, epicardial placement of bi-layered, a...

journal_title：Biomaterials

authors： Kobayashi K,Ichihara Y,Sato N,Umeda N,Fields L,Fukumitsu M,Tago Y,Ito T,Kainuma S,Podaru M,Lewis-McDougall F,Yamahara K,Uppal R,Suzuki K

更新日期：2019-07-01 00:00:00

abstract：:The long-term behaviour of cellulose sponge implants, 10 x 10 x 5 mm in size, and tissue reactions in and around them were examined in the subcutaneous tissue of the rat from 1 to 60 weeks after implantation. The cellulose sponge used was filled up with connective tissue 4 to 8 weeks after implantation. Histologically...

journal_title：Biomaterials

authors： Märtson M,Viljanto J,Hurme T,Laippala P,Saukko P

更新日期：1999-11-01 00:00:00

abstract：:AuCu and AuAg alloys (30 at. % Au) have been immersed in aqueous solutions of chloride and sulphide with additions of protein (mucin). The surfaces of the alloys were subsequently analysed by means of ESCA and compared with previous and similar tests without addition of mucin. No noticeable effect of the mucin additio...

journal_title：Biomaterials

authors： Herø H,Hultquist G,Odén A

更新日期：1985-11-01 00:00:00

abstract：:The adsorption of bovine serum albumin (BSA) on to titanium powder has been studied as a function of protein concentration and pH, and in the presence of calcium and phosphate ions. Isotherm data have shown that the adsorption process does not follow the Langmuir model (inflection points). The maximum adsorption (Adma...

journal_title：Biomaterials

authors： Wassell DT,Embery G

更新日期：1996-05-01 00:00:00

abstract：:Polydispersed poly(L-lactic acid) (PLLA) membranes comprised of blends of monodispersed PLLA of weight average molecular weight of 82,500 and 7600 were fabricated to investigate the effect of polydispersity on degradation characteristics. The PLLA blends exhibited large spherulites of high molecular weight chains embe...

journal_title：Biomaterials

authors： von Recum HA,Cleek RL,Eskin SG,Mikos AG

更新日期：1995-04-01 00:00:00

abstract：:We investigated the feasibility and efficacy of target thrombolysis with recombinant tissue plasminogen activator (rtPA) covalently bound to magnetic nanoparticle (MNP) and retained to the target site in vivo by an external magnet. Polyacrylic acid-coated magnetite (PAA-MNP, 246 nm) was synthesized and characterized; ...

journal_title：Biomaterials

authors： Ma YH,Wu SY,Wu T,Chang YJ,Hua MY,Chen JP

更新日期：2009-07-01 00:00:00

abstract：:The dynamic regulation of integrin-binding peptides is crucial for chondrogenic differentiation. Here, we revealed the feasibility for flexible modification of RGD by embedding a large molecular weight and slightly charged (isoelectric point, 6-6.25) RGD-chimeric protein (CBD-RGD) with cellulose-binding domain (CBD) i...

journal_title：Biomaterials

authors： Chang JC,Hsu SH,Chen DC

更新日期：2009-10-01 00:00:00

abstract：:This animal study (domestic pig) examined the bone formation after filling defined defects with autogenous bone or a collagen lyophilisat in combination with Platelet-rich-plasma (PRP) by evaluating bone matrix proteins. Six groups, both materials with and without PRP in two concentrations (+ 1, + 2) were compared to ...

journal_title：Biomaterials

authors： Thorwarth M,Rupprecht S,Falk S,Felszeghy E,Wiltfang J,Schlegel KA

更新日期：2005-05-01 00:00:00

abstract：:A human-human oligodendroglial cell line MO3.13 was chosen in this study to model the loss of oligodendrocytes that occurs during episodes of multiple sclerosis. The influence of mercuric chloride (HgCl(2)) upon cell viability specifically the mode of cell death, whether by an active apoptotic mechanism or passive nec...

journal_title：Biomaterials

authors： Issa Y,Watts DC,Duxbury AJ,Brunton PA,Watson MB,Waters CM

更新日期：2003-03-01 00:00:00

abstract：:Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide. However, the current pharmacological approaches used to treat OA are largely palliative. Being the hallmark of OA, the cartilage extracellular matrix (ECM) destruction and abnormal homeostasis is gaining more attention as a therapeuti...

journal_title：Biomaterials

authors： Peng Z,Sun H,Bunpetch V,Koh Y,Wen Y,Wu D,Ouyang H

更新日期：2021-01-01 00:00:00

abstract：:Branched polyesters of the general structure poly[vinyl-3-(dialkylamino)alkylcarbamate-co-vinyl acetate-co-vinyl alcohol]-graft-poly(d,l-lactide-co-glycolide) have shown potential for nano- and micro-scale drug delivery systems. For further optimization of this polymer class their cytotoxicity needs to be characterize...

journal_title：Biomaterials

authors： Unger F,Wittmar M,Kissel T

更新日期：2007-03-01 00:00:00

abstract：:Besides as an inert carrier for hydrophobic anticancer agents, polymeric micelles composed of di-block copolymer poly(ethylene glycol)-poly(lactic acid) (PEG-b-PLA) function as biological response modifiers including reversal of multidrug resistance in cancer. However, the uptake mechanisms and the subsequent intracel...

journal_title：Biomaterials

authors： Zhang Z,Xiong X,Wan J,Xiao L,Gan L,Feng Y,Xu H,Yang X

更新日期：2012-10-01 00:00:00

abstract：:The present work assesses the potential of three-dimensional porous titanium scaffolds produced by a novel powder metallurgy process for applications in bone engineering through in vitro experimentation. Mouse MC3T3-E1 pre-osteoblasts were used to investigate the proliferation (DNA content), differentiation (alkaline ...

journal_title：Biomaterials

authors： St-Pierre JP,Gauthier M,Lefebvre LP,Tabrizian M

更新日期：2005-12-01 00:00:00

abstract：:Implantation of a medical implant within the body inevitably triggers a host inflammatory response that negatively impacts its function and longevity. Nevertheless, the degree and severity of this response may be reduced by selecting appropriate materials, implant geometry, surface topography and surface treatment. He...

journal_title：Biomaterials

authors： Li J,Chu MK,Gordijo CR,Abbasi AZ,Chen K,Adissu HA,Löhn M,Giacca A,Plettenburg O,Wu XY

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study was to develop an effective drug delivery system for the simultaneous topical delivery of two anti-inflammatory drugs, spantide II (SP) and ketoprofen (KP). To achieve this primary goal, we have developed a skin permeating nanogel system (SPN) containing surface modified polymeric bilayered nanop...

journal_title：Biomaterials

authors： Shah PP,Desai PR,Patel AR,Singh MS

更新日期：2012-02-01 00:00:00

abstract：:The peripheral nerve contains three barriers which include the blood-nerve barrier consisting of endoneurial vessels and the perineurium as well as autotypic junctions in Schwann cells. The perineurium prevents diffusion of perineurally injected drugs that can be used for selective regional pain control. It is compose...

journal_title：Biomaterials

authors： Yang S,Krug SM,Heitmann J,Hu L,Reinhold AK,Sauer S,Bosten J,Sommer C,Fromm M,Brack A,Rittner HL

更新日期：2016-03-01 00:00:00

abstract：:Induced pluripotent stem (iPS) cells have been generated from various somatic cells; however, a major restriction of the technology is the use of potentially harmful genome-integrating viral DNAs. Here, without a viral vector, we generated iPS cells from fibroblasts using a non-viral magnetic nanoparticle-based transf...

journal_title：Biomaterials

authors： Lee CH,Kim JH,Lee HJ,Jeon K,Lim H,Choi Hy,Lee ER,Park SH,Park JY,Hong S,Kim S,Cho SG

更新日期：2011-10-01 00:00:00

abstract：:Highly fluorescent core-shell silica nanoparticles made by the modified Stöber process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostati...

journal_title：Biomaterials

authors： Fuller JE,Zugates GT,Ferreira LS,Ow HS,Nguyen NN,Wiesner UB,Langer RS

更新日期：2008-04-01 00:00:00

abstract：:High sensitivity at ultra-high field (UHF) and sufficient potential to penetrate the brain are the most desirable characteristics in the development of contrast agents (CAs) for magnetic resonance imaging (MRI). However, incorporating such qualities into a single nanocarrier is challenging. Herein, we report a new str...

journal_title：Biomaterials

authors： Kim HK,Baek AR,Choi G,Lee JJ,Yang JU,Jung H,Lee T,Kim D,Kim M,Cho A,Lee GH,Chang Y

更新日期：2020-06-01 00:00:00

abstract：:The objective of this study was to investigate the effect of repeated applications of a neutral NaF solution on the surface roughness of four conventional glass ionomer cements (GIC) (ChemFil Superior encapsulated, Fuji Cap II, Ketac-Fil and Hi Dense), three resin-modified (RM-) GIC (Fuji II LC encapsulated, Photac-Fi...

journal_title：Biomaterials

authors： De Witte AM,De Maeyer EA,Verbeeck RM

更新日期：2003-05-01 00:00:00

abstract：:Solid tissues in the body possess a range of stiffness and provide cells with an instructive microenvironment. Scaffolds in tissue engineering should be rationally designed to become an adhesion substrate friendly to cells. Schwann cells are the principal glial cell in the peripheral nervous system and used as support...

journal_title：Biomaterials

authors： Gu Y,Ji Y,Zhao Y,Liu Y,Ding F,Gu X,Yang Y

更新日期：2012-10-01 00:00:00

abstract：:Programmed cell death-ligand 1 (PD-L1)-based immune checkpoint blockade therapy using the anti-PD-L1 antibody is effective for a subset of patients with advanced metastatic melanoma but about half of the patients do not respond to the therapy because of the tumor immunosuppressive microenvironment. Immunogenic cell de...

journal_title：Biomaterials

authors： Qiu N,Liu Y,Liu Q,Chen Y,Shen L,Hu M,Zhou X,Shen Y,Gao J,Huang L

更新日期：2020-12-17 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:This study examined the nature of the surface presented by a machinable feldspathic porcelain and by a machinable glass-ceramic for bonding to conventional composite luting agents and measured the bond strengths which may be achieved with various surface treatments. There was no significant difference between the bond...

journal_title：Biomaterials

authors： Jedynakiewicz NM,Martin N

更新日期：2001-04-01 00:00:00

abstract：:At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release from AuNPs was de...

journal_title：Biomaterials

authors： Bhang SH,Han J,Jang HK,Noh MK,La WG,Yi M,Kim WS,Kwon YK,Yu T,Kim BS

更新日期：2015-07-01 00:00:00