Highly brain-permeable apoferritin nanocage with high dysprosium loading capacity as a new T2 contrast agent for ultra-high field magnetic resonance imaging.

abstract：:The aim of this work was to develop a new type of D-alpha-tocopheryl polyethylene glycol 1000 succinate mono-ester (TPGS) coated multi-functional (theranostic) liposomes, which contain both docetaxel and quantum dots (QDs) for cancer imaging and therapy. Non-targeting and folate receptor targeting TPGS coated theranos...

journal_title：Biomaterials

authors： Muthu MS,Kulkarni SA,Raju A,Feng SS

更新日期：2012-04-01 00:00:00

abstract：:Self-assembly is a prominent phenomenon observed in nature. Inspired by this thermodynamically favorable approach, several natural and synthetic materials have been investigated to develop functional systems for various biomedical applications, including drug delivery. Furthermore, layered self-assembled systems provi...

journal_title：Biomaterials

authors： Sarode A,Annapragada A,Guo J,Mitragotri S

更新日期：2020-02-29 00:00:00

abstract：:For a temporomandibular joint prosthesis, an estimation of the wear rate was needed, prior to patient application. Therefore, we determined the in vitro wear rate of the ball-socket articulation of this prosthesis, consisting of a metal head and an ultra-high molecular weight polyethylene (UHMWPE) cup. The basic testi...

journal_title：Biomaterials

authors： Van Loon JP,Verkerke GJ,de Bont LG,Liem RS

更新日期：1999-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the loss of neurogenesis and excessive induction of apoptosis. The induction of neurogenesis and inhibition of apoptosis may be a promising therapeutic approach to combating the disease. Celecoxib (CB), a cyclooxygenase-2 specific inhibitor, could offer neuroprotection. Spe...

journal_title：Biomaterials

authors： Guo JW,Guan PP,Ding WY,Wang SL,Huang XS,Wang ZY,Wang P

更新日期：2017-11-01 00:00:00

abstract：:Parkinson's disease (PD) is an oxidative stress-mediated neurodegenerative disorder caused by selective dopaminergic neuronal death in the midbrain substantia nigra. Paraoxonase 1 (PON1) is a potent inhibitor of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) against oxidation by destroying biological...

journal_title：Biomaterials

authors： Kim MJ,Park M,Kim DW,Shin MJ,Son O,Jo HS,Yeo HJ,Cho SB,Park JH,Lee CH,Kim DS,Kwon OS,Kim J,Han KH,Park J,Eum WS,Choi SY

更新日期：2015-09-01 00:00:00

abstract：:The authors have evaluated adhesive protein expression and cytokine production by human umbilical vein endothelial cells cultured in contact with polyethylene terephthalate (PET). ELAM-1, ICAM-1 and VCAM-1 expression was determined by flow cytometry; the concentration of interleukin-1 alpha (IL-1 alpha), interleukin-6...

journal_title：Biomaterials

authors： Cenni E,Granchi D,Ciapetti G,Verri E,Cavedagna D,Gamberini S,Di Leo A,Pizzoferrato A

更新日期：1996-11-01 00:00:00

abstract：:The formation of a confluent endothelium on expanded polytetrafluoroethylene (PTFE) vascular prostheses has never been observed. This lack of endothelialization is known to be one of the main reasons leading to the development of thromboses and/or intimal hyperplasia. In this context, several efforts were put forward ...

journal_title：Biomaterials

authors： Crombez M,Chevallier P,-Gaudreault RC,Petitclerc E,Mantovani D,Laroche G

更新日期：2005-12-01 00:00:00

abstract：:The maximum capacity of a hydrophobic adsorbent is interpreted in terms of square or hexagonal (cubic and face-centered-cubic, FCC) interfacial packing models of adsorbed blood proteins in a way that accommodates experimental measurements by the solution-depletion method and quartz-crystal-microbalance (QCM) for the h...

journal_title：Biomaterials

authors： Kao P,Parhi P,Krishnan A,Noh H,Haider W,Tadigadapa S,Allara DL,Vogler EA

更新日期：2011-02-01 00:00:00

abstract：:Based on the hydrophobic interaction with biomembranes, PFVYLI (PFV), a hydrophobic penetration peptide (HPP), was initially introduced to modify doxorubicin-loaded stealth-sustained liposomes (PFV-SSLs-DOX) against different breast cancer cell phenotypes irrespective of their receptor expression or antigen presence. ...

journal_title：Biomaterials

authors： Cai D,Gao W,He B,Dai W,Zhang H,Wang X,Wang J,Zhang X,Zhang Q

更新日期：2014-02-01 00:00:00

abstract：:Biomimetic materials that target the immune system and generate an anti-tumor responses hold promise in augmenting cancer immunotherapy. These synthetic materials can be engineered and optimized for their biodegradability, physical parameters such as shape and size, and controlled release of immune-modulators. As thes...

journal_title：Biomaterials

authors： Kosmides AK,Meyer RA,Hickey JW,Aje K,Cheung KN,Green JJ,Schneck JP

更新日期：2017-02-01 00:00:00

abstract：:Tissue-engineered organs and implants hold promise for the replacement of damaged and diseased organs. However, the foreign body response (FBR) is a major obstacle that compromises the function of tissue-engineered constructs, typically causing them to fail. Two components of FBR are an inflammatory response and a lac...

journal_title：Biomaterials

authors： Browne S,Monaghan MG,Brauchle E,Berrio DC,Chantepie S,Papy-Garcia D,Schenke-Layland K,Pandit A

更新日期：2015-11-01 00:00:00

abstract：:Gelatin and dextran were blended and crosslinked to form enzymatically degradable interpenetrating polymeric networks (IPNs) as materials for degradable implants. Several crosslinking methods were investigated including treatment with glyceraldehyde, thermal hardening, and chelation of dextran by divalent metal cation...

journal_title：Biomaterials

authors： Kosmala JD,Henthorn DB,Brannon-Peppas L

更新日期：2000-10-01 00:00:00

abstract：:Hepatocytes derived from human pluripotent stem cells (hPSCs) are promising candidates for cell therapy and drug discovery. However, it remains challenging to efficiently purify hepatocytes from undesired cell types after differentiation and to accurately monitor grafted cells after transplantation. Indocyanine Green ...

journal_title：Biomaterials

authors： Park JY,Han J,Jung HS,Lee G,Kim HJ,Cho GS,Park HJ,Han C,Kim JS,Kim JH

更新日期：2019-11-01 00:00:00

abstract：:Animal models have been used extensively to investigate the biology of fracture healing and spinal fusion. The goal of each spinal fusion model is to try and reproduce the correct sequence of events during osseous healing in humans. Animal models allow us the capability of dialing in fusion rates and fusion parameters...

journal_title：Biomaterials

authors： Khan SN,Lane JM

更新日期：2004-04-01 00:00:00

abstract：:Airway tracts serve as a conduit of transport in the respiratory system. Architecturally, these are composed of cartilage rings that offer flexibility and prevent collapse during normal breathing. To this end, the successful regeneration of an airway tract requires the presence of differentiated chondrocytes and airwa...

journal_title：Biomaterials

authors： Ghezzi CE,Marelli B,Donelli I,Alessandrino A,Freddi G,Nazhat SN

更新日期：2014-08-01 00:00:00

abstract：:Bioactive composites composed of hydroxyapatite containing glass (HA-G) as a coating and titanium (Ti) or titanium alloy implants as a substrate were prepared by the Cullet method. This method results in the HA-G coating layer on the substrate with a compositional gradient in HA concentration. The results of in vitro ...

journal_title：Biomaterials

authors： Yamada K,Imamura K,Itoh H,Iwata H,Maruno S

更新日期：2001-08-01 00:00:00

abstract：:Biologic scaffolds composed of extracellular matrix (ECM) have been used to facilitate the repair and reconstruction of a variety of tissues in clinical and pre-clinical studies. The clinical utility of such scaffolds can be limited by the geometric and mechanical properties of the tissue or organ from which the ECM i...

journal_title：Biomaterials

authors： Freytes DO,Martin J,Velankar SS,Lee AS,Badylak SF

更新日期：2008-04-01 00:00:00

abstract：:This study was undertaken to evaluate the influence of storage conditions on the shelf-life of porcine bioprosthetic valves. Fifty-five unimplanted porcine bioprostheses have been evaluated. The valves were stored in 0.5% buffered glutaraldehyde solution for different periods of time (7, 23 and 32 months). Twenty-eigh...

journal_title：Biomaterials

authors： Julien M,Létouneau DR,Marois Y,Cardou A,King MW,Guidoin R,Chachra D,Lee JM

更新日期：1997-04-01 00:00:00

abstract：:A three layer (trilayer) polymeric micelle system based on the self-association of the triblock polymer poly(ethylene glycol)-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl] aspartamide}-b-poly(ε-caprolactone) (PEG-b-PAsp(DET)-b-PCL) has been synthesized and investigated for combination delivery of rapamycin (RAP) and siRNA ...

journal_title：Biomaterials

authors： Zeng S,Xiong MP

更新日期：2013-09-01 00:00:00

abstract：:Thrombomodulin (TM) is a newly described endothelial cell-associated protein that functions as a potent natural anticoagulant by converting thrombin from a procoagulant protease to an anticoagulant. In this study, focussing on the application of TM for biomedical materials, recombinant human TM (hTM) was immobilized o...

journal_title：Biomaterials

authors： Kishida A,Ueno Y,Fukudome N,Yashima E,Maruyama I,Akashi M

更新日期：1994-08-01 00:00:00

abstract：:Beads of polytetrafluoroethylene were used to investigate adsorption of thrombin and the influence of the adsorbed protease on a subsequent deposition of fibrinogen. Adsorption of active thrombin was not detected by a specific fluorogenic substrate unless > 0.1 units/ml had been applied. Adsorption was considerably im...

journal_title：Biomaterials

authors： Schlosser E,Simler R,Hörmann H

更新日期：1993-04-01 00:00:00

abstract：:A multifunctional organic-inorganic hybrid nanocapsule based on Bi2S3-embedded poly (lactic-co-glycolic acid) (PLGA) nanocapsule has been elaborately designed to combine the merits of both polymeric shell structure and Bi2S3 nanoparticles. Hydrophobic Bi2S3 nanoparticles were successfully introduced into the PLGA nano...

journal_title：Biomaterials

authors： Yao MH,Ma M,Chen Y,Jia XQ,Xu G,Xu HX,Chen HR,Wu R

更新日期：2014-09-01 00:00:00

abstract：:In arterial replacement there is a clear clinical need for a functional substitute possessing appropriate haemocompatible properties to be implanted as small diameter artery. Endothelial cell seeding constitutes an appreciated method to improve blood compatibility on the condition that cells firmly adhere to the suppo...

journal_title：Biomaterials

authors： Rémy M,Durand M,Menu P,Voegel JC,Ponsot JF,Bérard X,Harmand MF,Bordenave L

更新日期：2013-12-01 00:00:00

abstract：:Novel collagen scaffolds possessing predefined and reproducible internal channels with widths of 135 microm and greater have been produced. The process employed to make the collagen scaffold utilises a sacrificial mould, manufactured using solid freeform fabrication technology, and critical point drying technique. A c...

journal_title：Biomaterials

authors： Sachlos E,Reis N,Ainsley C,Derby B,Czernuszka JT

更新日期：2003-04-01 00:00:00

abstract：:A series of mesoporous silica nanoparticles (MSNs) were synthesized using the co-structure directing method. A non-cytotoxic anionic surfactant, undec-1-en-11-yltetra(ethylene glycol) phosphate monoester surfactant (PMES), was used as a structure directing agent (SDA) together with aminopropyltrimethoxysilane that fun...

journal_title：Biomaterials

authors： Tsai CH,Vivero-Escoto JL,Slowing II,Fang IJ,Trewyn BG,Lin VS

更新日期：2011-09-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is an attractive vaccination method compared with conventional injectable vaccines because it is easier to administer without pain. We developed a dissolving microneedle patch (MicroHyala, MH) made of hyaluronic acid and showed that transcutaneous vaccination using MH induced a strong...

journal_title：Biomaterials

authors： Hirobe S,Azukizawa H,Hanafusa T,Matsuo K,Quan YS,Kamiyama F,Katayama I,Okada N,Nakagawa S

更新日期：2015-07-01 00:00:00

abstract：:The abundant extracellular matrix (ECM) in the glioma microenvironment play a critical role in the maintenance of glioma morphology, glioma cells differentiation and proliferation, but little has been done to understand the feasibility of ECM as the therapeutic target for glioma therapy. In this study, a drug delivery...

journal_title：Biomaterials

authors： Zhang B,Shen S,Liao Z,Shi W,Wang Y,Zhao J,Hu Y,Yang J,Chen J,Mei H,Hu Y,Pang Z,Jiang X

更新日期：2014-04-01 00:00:00

abstract：:Although photothermal therapy (PTT) and photodynamic therapy (PDT) are widely commended for tumor treatment recently, they still suffer severe challenges due to the non-specificity of photothermal agents (PTAs)/photosensitizers (PSs) and hypoxic tumor microenvironment. Here, an oxygen independent biomimetic nanoplatfo...

journal_title：Biomaterials

authors： Zhang C,Liu WL,Bai XF,Cheng SX,Zhong ZL,Zhang XZ

更新日期：2019-04-01 00:00:00

abstract：:In order to overcome the problem of rapid clearance of the polysaccharide hyaluronic acid (Hyal) in the treatment of osteoarthritis (OA), a 50% cross-linked Hyal hydrogel (Hyal 50%) was synthesised. The 50% refers to the amount of COOH groups of the polysaccharide involved in the cross-linking reaction. i.e. 50% of th...

journal_title：Biomaterials

authors： Barbucci R,Lamponi S,Borzacchiello A,Ambrosio L,Fini M,Torricelli P,Giardino R

更新日期：2002-12-01 00:00:00

abstract：:G-rich oligonucleotides tend to fall into kinetically trapped unstable structures because of their conformational polymorphism. Nucleic acid chaperones accelerate association of nucleic acids assemblies into the thermodynamically most stable conformations by decreasing the energy barrier for breakage or re-assembly of...

journal_title：Biomaterials

authors： Moriyama R,Shimada N,Kano A,Maruyama A

更新日期：2011-10-01 00:00:00