Intracellular delivery of core-shell fluorescent silica nanoparticles.

abstract：:Biologic scaffold materials composed of extracellular matrix (ECM) are typically derived by processes that involve decellularization of tissues or organs. Preservation of the complex composition and three-dimensional ultrastructure of the ECM is highly desirable but it is recognized that all methods of decellularizati...

journal_title：Biomaterials

authors： Crapo PM,Gilbert TW,Badylak SF

更新日期：2011-04-01 00:00:00

abstract：:The influence of processing-introduced flaws and heat treatment on the strength degradation of the dental core material has recently been observed. However, there are insufficient studies which investigate the role of grinding, grinding orientation, sandblasting, polishing and heat treatment on the strength of In-Cera...

journal_title：Biomaterials

authors： Guazzato M,Albakry M,Quach L,Swain MV

更新日期：2004-05-01 00:00:00

abstract：:Biomaterials interface with toll-like receptor (TLR) 9-mediated innate immunity in a wide range of medical applications, such as tissue implants and drug delivery systems. The stimulation of TLR9 can lead to two different signaling pathways, resulting in the generation of proinflammatory cytokines (i.e. IL-6) and/or t...

journal_title：Biomaterials

authors： Chen HC,Sun B,Tran KK,Shen H

更新日期：2011-02-01 00:00:00

abstract：:In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cel...

journal_title：Biomaterials

authors： Ragelle H,Naba A,Larson BL,Zhou F,Prijić M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

更新日期：2017-06-01 00:00:00

abstract：:Matrix systems used to study complex three-dimensional (3D) cellular processes like mammary epithelial tissue morphogenesis and tumorigenesis ex vivo often require ill-defined biological components, which lead to poor reproducibility and a lack of control over physical parameters. In this study, a well-defined, tunabl...

journal_title：Biomaterials

authors： Nowak M,Freudenberg U,Tsurkan MV,Werner C,Levental KR

更新日期：2017-01-01 00:00:00

abstract：:Cell sheet technology has emerged as an important tissue engineering approach. Adipose-derived stem cells (ASCs) have valuable applications in regenerative medicine, but their stemness and differentiation capabilities in the cell sheet format have not been well investigated. In this study, we found that l-ascorbate 2-...

journal_title：Biomaterials

authors： Yu J,Tu YK,Tang YB,Cheng NC

更新日期：2014-04-01 00:00:00

abstract：:This work demonstrated the development of multifunctional silica nanotubes (SNT) by functionalization of their inner void and outer surface with magnetic-fluorescence nanocomposites and cationic polymers, respectively. The successful construction of BPEI-SNT was established by electron energy loss spectroscopy in conj...

journal_title：Biomaterials

authors： Namgung R,Zhang Y,Fang QL,Singha K,Lee HJ,Kwon IK,Jeong YY,Park IK,Son SJ,Kim WJ

更新日期：2011-04-01 00:00:00

abstract：:Recent developments in cell culture techniques have made it possible to study the cellular mechanisms involved in carcinogenesis and to apply these methods as screening tools in vitro. This study investigated and compared the ability of the metals most commonly used in orthopedic implants to induce toxicity and neopla...

journal_title：Biomaterials

authors： Doran A,Law FC,Allen MJ,Rushton N

更新日期：1998-04-01 00:00:00

abstract：:Meniscus injuries are prevalent in orthopedic diagnosis. The reconstruction of the structural inhomogeneity and anisotropy of the meniscus is a major challenge in clinical practice. Meniscal tissue engineering has emerged as a potential alternative for the treatment of various meniscal diseases and injuries. In this s...

journal_title：Biomaterials

authors： Chae S,Lee SS,Choi YJ,Hong DH,Gao G,Wang JH,Cho DW

更新日期：2021-01-01 00:00:00

abstract：:A lauric acid modified dextran-agmatine bioconjugate (Dex-L-Agm) was prepared by 1,1'-carbonyldiimidazole (CDI) activation and the nucleophilic reaction between tosyl of tosylated dextran and primary amine of agmatine. Dextran-agmatine bioconjugates (Dex-Agm) were capable of condensing DNA into nanocomplexes, and comb...

journal_title：Biomaterials

authors： Yang J,Liu Y,Wang H,Liu L,Wang W,Wang C,Wang Q,Liu W

更新日期：2012-01-01 00:00:00

abstract：:The development of synthetic hydrogels analogs for the extracellular matrix has proven a useful and important tool to study the role of specific signals on biological outcomes in vitro and to serve as scaffolds for tissue repair. Although the importance of physical properties (e.g. microstructure and stiffness) in the...

journal_title：Biomaterials

authors： Darling NJ,Hung YS,Sharma S,Segura T

更新日期：2016-09-01 00:00:00

abstract：:An ideal approach for bone tissue engineering allows for osteoconductivity, osteoinductivity, and cell transplantation. In this study, we examined coprecipitation and surface adsorption schemes with respect to their abilities to control the spatial quantity and localization of a model protein, bovine serum albumin (BS...

journal_title：Biomaterials

authors： Luong LN,Hong SI,Patel RJ,Outslay ME,Kohn DH

更新日期：2006-03-01 00:00:00

abstract：:The search for a cell-supporting scaffold with controlled topography and surface chemistry is a constant topic within tissue engineering. Here we have employed M13 phages, which are genetically modifiable biological nanofibers (∼ 880 nm long and ∼ 6.6 nm wide) non-toxic to human beings, to form films for supporting th...

journal_title：Biomaterials

authors： Zhu H,Cao B,Zhen Z,Laxmi AA,Li D,Liu S,Mao C

更新日期：2011-07-01 00:00:00

abstract：:Vaccination is an effective medical intervention for preventing disease. However, without an adjuvant, most subunit vaccines are poorly immunogenic. This work develops a bioinspired nanocomposite hyaluronic acid hydrogel system that incorporates N-trimethyl chitosan nanoparticles (TMC/NPs) that carry a model subunit v...

journal_title：Biomaterials

authors： Korupalli C,Pan WY,Yeh CY,Chen PM,Mi FL,Tsai HW,Chang Y,Wei HJ,Sung HW

更新日期：2019-09-01 00:00:00

abstract：:This article reviews the controlled release of biologically active agents by the erosion or chemical degradation of a polymer matrix into which the agent is incorporated. Chemically bound active agents and work on steroid release from cholesterol implants are not covered. The mechanisms of polymer erosion discussed ar...

journal_title：Biomaterials

authors： Heller J

更新日期：1980-01-01 00:00:00

abstract：:Osteomyelitis characterized by an inflammatory response often leads to bone loss and the spread of bacterial infection to surrounding soft tissues. To overcome the side effects induced by the systemic antibiotic treatment for osteomyelitis, recent investigations have explored the use of antibiotic-loaded undegradable ...

journal_title：Biomaterials

authors： Peng KT,Chen CF,Chu IM,Li YM,Hsu WH,Hsu RW,Chang PJ

更新日期：2010-07-01 00:00:00

abstract：:There is great demand for constructing well-organized three-dimensional (3D) tissues in vitro. Here, we developed a 3D stacked culture method using biodegradable poly(d,l-lactide-co- glycolide) (PLGA) membranes with defined topography. Pore size and porosity of the membranes can be controlled by changing the moisture ...

journal_title：Biomaterials

authors： Kasuya J,Sudo R,Tamogami R,Masuda G,Mitaka T,Ikeda M,Tanishita K

更新日期：2012-03-01 00:00:00

abstract：:Immune response testing of biomaterials is an essential component of biocompatibility assessment, particularly when the materials of interest are used to design bioresorbable scaffolds with the potential to promote in situ regeneration. Current trends in immune response testing of biomaterials typically examine few el...

journal_title：Biomaterials

authors： Smith MJ,White KL Jr,Smith DC,Bowlin GL

更新日期：2009-01-01 00:00:00

abstract：:Two kinds of layered atelocollagen materials cross-linked with hexamethylene diisocyanate (HMDIC), starch dialdehyde and glyoxal were enzymatically treated by bacterial collagenase. Evaluating collagenase digestion assay for these material showed progressive differences, particularly in the group of samples cross-link...

journal_title：Biomaterials

authors： Vizárová K,Bakos D,Rehákova M,Petríkova M,Panáková E,Koller J

更新日期：1995-11-01 00:00:00

abstract：:Xenogeneic extracellular matrix (ECM) can be harvested and configured to function as a bioscaffold for tissue and organ reconstruction. The mechanical properties of the ECM vary depending upon the tissue from which it is harvested. Likewise, the manufacturing steps required to develop ECMs into medical grade devices w...

journal_title：Biomaterials

authors： Freytes DO,Badylak SF,Webster TJ,Geddes LA,Rundell AE

更新日期：2004-05-01 00:00:00

abstract：:Both efficiency and safety profiles are crucial for promotion of gene delivery systems towards practical applications. A promising template system was previously developed based on block catiomer of poly(ethylene glycol) (PEG)-b-poly{N'-[N-(2-aminoethyl)-2-aminoehtyl]aspartamide}-cholesteryl [PEG-PAsp(DET)-cholesteryl...

journal_title：Biomaterials

authors： Chen Q,Osada K,Ge Z,Uchida S,Tockary TA,Dirisala A,Matsui A,Toh K,Takeda KM,Liu X,Nomoto T,Ishii T,Oba M,Matsumoto Y,Kataoka K

更新日期：2017-01-01 00:00:00

abstract：:The bioactivity of plasma-sprayed hydroxyapatite (HA)/Ti-6Al-4V composite coatings was studied by soaking the coatings in simulated body fluid (SBF) for up to 8 weeks. This investigation was aimed at elucidating the biological behaviour of plasma-sprayed HA/Ti-6Al-4V composite coatings by analyzing the changes in chem...

journal_title：Biomaterials

authors： Gu YW,Khor KA,Cheang P

更新日期：2003-04-01 00:00:00

abstract：:Human induced pluripotent stem cell (hiPSC) derived angiogenesis models present a unique opportunity for patient-specific platforms to study the complex process of angiogenesis and the endothelial cell response to biomaterial and biophysical changes in a defined microenvironment. We present a refined method for differ...

journal_title：Biomaterials

authors： Natividad-Diaz SL,Browne S,Jha AK,Ma Z,Hossainy S,Kurokawa YK,George SC,Healy KE

更新日期：2019-02-01 00:00:00

abstract：:The present study deals with the synthesis and characterization of radiopaque polymers which could, when solubilized in an appropriate water-miscible solvent, be useful embolic materials for the treatment of cerebral aneurysms and arteriovenous malformations. For this purpose cellulose (both microcrystalline and powde...

journal_title：Biomaterials

authors： Mottu F,Rüfenacht DA,Laurent A,Doelker E

更新日期：2002-01-01 00:00:00

abstract：:A amphiphilic block copolymer composed of conventional monomethoxy (polyethylene glycol)-poly (d,l-lactide-co-glycolide)-poly (l-lysine) (mPEG-PLGA-b-PLL) was synthesized. The chemical structure of this copolymer and its precursors was confirmed by Fourier Transform Infrared Spectroscopy (FTIR), (1)H Nuclear Magnetic ...

journal_title：Biomaterials

authors： Liu P,Yu H,Sun Y,Zhu M,Duan Y

更新日期：2012-06-01 00:00:00

abstract：:The erosion of composite polymer matrices made of slow and fast eroding polymers was investigated. These matrices can be used as implants that release drugs in a preprogrammed way. To understand the mechanism of drug release, the erosion of cylindrical polymer matrices made of several layers of different polymers was ...

journal_title：Biomaterials

authors： Göpferich A

更新日期：1997-03-01 00:00:00

abstract：:Unhealed chronic wounds often deteriorate into multiple infection with several kinds of bacteria and excessive proteolytic wound exudate and remains one of the common healthcare issues. Here, the functional and antimicrobial hydrogel and cryogel biomaterials were prepared from glycol chitosan and a novel biodegradable...

journal_title：Biomaterials

authors： Chen TY,Wen TK,Dai NT,Hsu SH

更新日期：2020-12-16 00:00:00

abstract：:Most urgent health problems are related to a blood vessel formation failure. The use of stem cells from different sources or species for both in vitro and in vivo engineering of endothelium does not necessarily imply their direct commitment towards a vascular phenotype. In the present study, we used human amniotic flu...

journal_title：Biomaterials

authors： Mirabella T,Cilli M,Carlone S,Cancedda R,Gentili C

更新日期：2011-05-01 00:00:00

abstract：:The recreation of an in vitro microenvironment to understand and manipulate the proliferation and migration of invasive breast cancer cells may allow one to put a halt to their metastasis capacity. Invasive cancer cells have been linked to embryonic stem (ES) cells as they possess certain similar characteristics and g...

journal_title：Biomaterials

authors： Raof NA,Raja WK,Castracane J,Xie Y

更新日期：2011-06-01 00:00:00

abstract：:Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine the feasibility of this technology for producing scaffolds for tissue engineering an aortic valve and the optimal concentration of collagen processed in this man...

journal_title：Biomaterials

authors： Taylor PM,Sachlos E,Dreger SA,Chester AH,Czernuszka JT,Yacoub MH

更新日期：2006-05-01 00:00:00