Long-term histological evaluation of hydroxyapatite ceramics in humans.

abstract：:Decellularized adipose tissue (DAT) has shown promise as an adipogenic bioscaffold for soft tissue augmentation and reconstruction. The objective of the current study was to investigate the effects of allogeneic adipose-derived stem/stromal cells (ASCs) on in vivo fat regeneration in DAT bioscaffolds using an immunoco...

journal_title：Biomaterials

authors： Han TT,Toutounji S,Amsden BG,Flynn LE

更新日期：2015-12-01 00:00:00

abstract：:In this work, therapeutic magnetic micro carriers (TMMC) guided in real time by a magnetic resonance imaging (MRI) system are proposed as a mean to improve drug delivery to tumor sites. MRI steering constraints and physiological parameters for the chemoembolization of liver tumors were taken into account to design mag...

journal_title：Biomaterials

authors： Pouponneau P,Leroux JC,Martel S

更新日期：2009-10-01 00:00:00

abstract：:Porous scaffolds for skin tissue engineering were fabricated by freeze-drying the mixture of collagen and chitosan solutions. Glutaraldehyde (GA) was used to treat the scaffolds to improve their biostability. Confocal laser scanning microscopy observation confirmed the even distribution of these two constituent materi...

journal_title：Biomaterials

authors： Ma L,Gao C,Mao Z,Zhou J,Shen J,Hu X,Han C

更新日期：2003-11-01 00:00:00

abstract：:Realization of systems able to both recruit cells and influence their fate (affecting their processes) represents a new approach for tissue regeneration. We investigated the potency of gene activated matrix (GAM) and implemented the GAM strategy in order to achieve a control of gene expression, as well as a specific c...

journal_title：Biomaterials

authors： Orsi S,De Capua A,Guarnieri D,Marasco D,Netti PA

更新日期：2010-01-01 00:00:00

abstract：:Studies have suggested that mesenchymal stem cells (MSCs) have therapeutic effects following traumatic brain injury (TBI). However, cell distribution and survival rate are two major barriers to their success as therapeutic treatment. The improvement of cell therapy using collagen delivery matrices had been reported. H...

journal_title：Biomaterials

authors： Guan J,Zhu Z,Zhao RC,Xiao Z,Wu C,Han Q,Chen L,Tong W,Zhang J,Han Q,Gao J,Feng M,Bao X,Dai J,Wang R

更新日期：2013-08-01 00:00:00

abstract：:Cationic solid lipid nanoparticles (cSLNs) are promising nanoparticles for controlled drug delivery. Increasing surface charge and/or reducing PEG density enhance cellular uptake of cSLNs in vitro, but for unknown reasons fail to improve drug delivery in vivo. Herein, we show that cSLNs present a risk for systemic pla...

journal_title：Biomaterials

authors： Wu X,Chen H,Wu C,Wang J,Zhang S,Gao J,Wang H,Sun T,Yang YG

更新日期：2018-02-01 00:00:00

abstract：:An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive insulin delivery systems have been developed by coupling glucose oxidase with a stimuli-responsive biomaterial. However, the challenge of achieving desirab...

journal_title：Biomaterials

authors： Volpatti LR,Facklam AL,Cortinas AB,Lu YC,Matranga MA,MacIsaac C,Hill MC,Langer R,Anderson DG

更新日期：2021-01-01 00:00:00

abstract：:Polymer-siRNA complexes (siRNA polyplexes) are being actively developed to improve the therapeutic application of siRNA. A major limitation for many siRNA polyplexes, however, is insufficient mRNA suppression. Given that modifying the sense strand of siRNA with 3' cholesterol (chol-siRNA) increases the activity of fre...

journal_title：Biomaterials

authors： Ambardekar VV,Han HY,Varney ML,Vinogradov SV,Singh RK,Vetro JA

更新日期：2011-02-01 00:00:00

abstract：:The aim of this study, in rabbit tibia, was an evaluation of the early reactions of the tissues to the insertion of polylactic membranes, used in connection with titanium implants. The specimens were retrieved after 1-4 weeks, and a histological analysis was performed. It was possible to see that, in the early implant...

journal_title：Biomaterials

authors： Piattelli A,Scarano A,Coraggio F,Matarasso S

更新日期：1998-05-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) 2-incorporated gelatin sponge is effective for in vivo osteoinduction. However, the modeling capacity of bone decreases with age. As atrial to stimulate effective bone formation for animals with decreased osteogenic potential, Wnt1 inducible signaling pathway protein (WISP) 1, an osteo...

journal_title：Biomaterials

authors： Kohara H,Tabata Y

更新日期：2011-08-01 00:00:00

abstract：:Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

journal_title：Biomaterials

authors： DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

更新日期：2020-11-01 00:00:00

abstract：:The aim of this study was to develop a hydrogel which would be suitable for corneal cell re-epithelialization when used as a corneal implant. To achieve this, a series of hydrogels were functionalized with primary amines by post-polymerization reactions between amine compounds and glycidyl ether groups attached to the...

journal_title：Biomaterials

authors： Rimmer S,Johnson C,Zhao B,Collier J,Gilmore L,Sabnis S,Wyman P,Sammon C,Fullwood NJ,MacNeil S

更新日期：2007-12-01 00:00:00

abstract：:In the traditional Chinese medicine, Gu-Sui-Bu [Drynaria fortunei (kunze) J. Sm] has been reported as a good enhancer for bone healing. In this experiment, we investigate the biochemical effects of this traditional Chinese medicine on the bone cells culture. Different concentrations of crude extract of Gu-Sui-Bu were ...

journal_title：Biomaterials

authors： Sun JS,Lin CY,Dong GC,Sheu SY,Lin FH,Chen LT,Wang YJ

更新日期：2002-08-01 00:00:00

abstract：:Cancer stem cells (CSCs) play pivotal roles in cancer metastasis, and strategies targeting cancer stemness may greatly reduce cancer metastasis and improve patients' survival. The canonical Wnt/β-catenin pathway plays critical roles in CSC generation and maintenance as well as in normal stem cells. Non-specifically su...

journal_title：Biomaterials

authors： Li Y,Xiao Y,Lin HP,Reichel D,Bae Y,Lee EY,Jiang Y,Huang X,Yang C,Wang Z

更新日期：2019-01-01 00:00:00

abstract：:Low molecular weight polyurethanes with sites for metal complexation were synthesized. The -SO(2) and the -COOH groups were incorporated into the polyurethane chain by the reactions of tri-functional monomers, 4,4'-bis(hydroxyphenyl)sulfone and 4,4'-bis(hydroxyphenyl) valeric acid with hexa-methylene di-isocyanate (HM...

journal_title：Biomaterials

authors： Acharya V,Prabha CR,Narayanamurthy C

更新日期：2004-08-01 00:00:00

abstract：:Composite particles made by growing nanoscopic silicon wires from the surface of monodispersed, microsized silica beads were tested in this study for their ability to affect the integrity and permeability of an epithelial cell layer. Polyethylene glycol (PEG) is known to sterically stabilize particles and prevent prot...

journal_title：Biomaterials

authors： Uskoković V,Lee PP,Walsh LA,Fischer KE,Desai TA

更新日期：2012-02-01 00:00:00

abstract：:Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Generally, the lipid systems presented the advantage of their low toxicity due to their composition of physiological lipids compared to polymeric particles. The physico-chemical stab...

journal_title：Biomaterials

authors： Heurtault B,Saulnier P,Pech B,Proust JE,Benoit JP

更新日期：2003-10-01 00:00:00

abstract：:microRNA-124 (miR-124), the most abundant miRNA of the CNS, was recently shown to modulate the polarization of activated microglia and infiltrating macrophages towards the anti-inflammatory M2 phenotype and protect neurons in various ways after brain disease. In ischemic stroke, microglia and macrophages of a detrimen...

journal_title：Biomaterials

authors： Hamzei Taj S,Kho W,Riou A,Wiedermann D,Hoehn M

更新日期：2016-06-01 00:00:00

abstract：:Menisci are one of the most commonly injured parts of the knee with a limited healing potential. This study focuses on fabrication and characterization of biomimetic surfaces for meniscal tissue engineering. To achieve this, a combination of hyaluronic acid/chitosan (HA/CH) mutilayers with covalently immobilized major...

journal_title：Biomaterials

authors： Tan GK,Dinnes DL,Butler LN,Cooper-White JJ

更新日期：2010-08-01 00:00:00

abstract：:A practical method of photocrosslinking high molecular weight poly(trimethylene carbonate)(PTMC) is presented. Flexible, elastomeric and biodegradable networks could be readily prepared by UV irradiating PTMC films containing pentaerythritol triacrylate (PETA) and a photoinitiator. The network characteristics, mechani...

journal_title：Biomaterials

authors： Bat E,Kothman BH,Higuera GA,van Blitterswijk CA,Feijen J,Grijpma DW

更新日期：2010-11-01 00:00:00

abstract：:Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...

journal_title：Biomaterials

authors： Khandare J,Mohr A,Calderón M,Welker P,Licha K,Haag R

更新日期：2010-05-01 00:00:00

abstract：:A method to fabricate porous, biodegradable conduits using a combined injection molding, thermally induced phase transition technique was developed which produced conduits with dimensionally toleranced, longitudinally aligned channels. The geometry of the channels was designed to approximate the architecture of periph...

journal_title：Biomaterials

authors： Sundback C,Hadlock T,Cheney M,Vacanti J

更新日期：2003-02-01 00:00:00

abstract：:This article is a review of recent developments of polymer-related stents mainly employed in the coronary arteries, including polymer-coated stents, biostable stents and biodegradable stents. Polymer paving is covered as well. The problems with the stents currently investigated and the development of new stents are di...

journal_title：Biomaterials

authors： Peng T,Gibula P,Yao KD,Goosen MF

更新日期：1996-04-01 00:00:00

abstract：:Injectable, biodegradable scaffolds are important biomaterials for tissue engineering and drug delivery. Hydrogels derived from natural polysaccharides are ideal scaffolds as they resemble the extracellular matrices of tissues comprised of various glycosaminoglycans (GAGs). Here, we report a new class of biocompatible...

journal_title：Biomaterials

authors： Tan H,Chu CR,Payne KA,Marra KG

更新日期：2009-05-01 00:00:00

abstract：:We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment. The properties of the Ch/beta-GP gels were characterized regarding chemical structure, surface morphology, and viscoelasticity. In vitro EA release rate from the EA loa...

journal_title：Biomaterials

authors： Kim S,Nishimoto SK,Bumgardner JD,Haggard WO,Gaber MW,Yang Y

更新日期：2010-05-01 00:00:00

abstract：:Renal regeneration approaches offer great potential for the treatment of chronic kidney disease, but their availability remains limited by the clinical challenges they pose. In the present study, we used continuous detergent perfusion to generate decellularized (DC) rat kidney scaffolds. The scaffolds retained intact ...

journal_title：Biomaterials

authors： Yu YL,Shao YK,Ding YQ,Lin KZ,Chen B,Zhang HZ,Zhao LN,Wang ZB,Zhang JS,Tang ML,Mei J

更新日期：2014-08-01 00:00:00

abstract：:Canonical transient receptor potential channel 6 (TRPC6) can play an important role in governing how cells perceive the surrounding material environment and regulate Ca(2+) signaling. We have designed a TRPC6 reporter based on fluorescence resonance energy transfer (FRET) to visualize the TRPC6-mediated calcium entry ...

journal_title：Biomaterials

authors： Lei L,Lu S,Wang Y,Kim T,Mehta D,Wang Y

更新日期：2014-03-01 00:00:00

abstract：:The protective role of different dentine fractions and of dentine slices in moderating the cytotoxicity of zinc oxide eugenol (ZOE) was investigated. The collagen fraction of dentine powder provided increased protection over intact powder. Slices of dentine offered greater protection probably by providing a physical b...

journal_title：Biomaterials

authors： Meryon SD,Jakeman KJ

更新日期：1986-11-01 00:00:00

abstract：:Retinal degenerations cause permanent visual loss and affect millions world-wide. Presently, a novel treatment highlights the potential of using biodegradable polymer scaffolds to induce differentiation and deliver retinal progenitor cells for cell replacement therapy. In this study, we engineered and analyzed a micro...

journal_title：Biomaterials

authors： Redenti S,Neeley WL,Rompani S,Saigal S,Yang J,Klassen H,Langer R,Young MJ

更新日期：2009-07-01 00:00:00

abstract：:The generation of intracellular reactive oxygen species (ROS) was optically monitored using ROS-sensitive gold nanoprobes in response to an exposure of nanoparticles (NPs). Fluorescent dye-labeled hyaluronic acid was grafted onto the surface of gold nanoparticles (HF-AuNPs) for imaging intracellular ROS. The ultrasens...

journal_title：Biomaterials

authors： Lee K,Lee H,Lee KW,Park TG

更新日期：2011-04-01 00:00:00