Continuous harvest of stem cells via partial detachment from thermoresponsive nanobrush surfaces.

abstract：:The present study deals with the effect of the type and chemical character of incorporated polyester (polyether blocks) on the hydrolytic stability of different types of polyurethane medical adhesive dressings. Diffusion parameters of the investigated polyurethane adhesives, giving information concerning the chemical ...

journal_title：Biomaterials

authors： Pavlova M,Draganova M

更新日期：1994-01-01 00:00:00

abstract：:Nano-scale modification of a segmented polyurethane (SPU) with cross-linked 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was performed to obtain a biocompatible elastomer. To control the domain size and the depth of the modified layer, various compositions of monomers, including MPC, 2-ethylhexyl methacrylat...

journal_title：Biomaterials

authors： Morimoto N,Watanabe A,Iwasaki Y,Akiyoshi K,Ishihara K

更新日期：2004-10-01 00:00:00

abstract：:Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To this end, we isolated...

journal_title：Biomaterials

authors： Mentink A,Hulsman M,Groen N,Licht R,Dechering KJ,van der Stok J,Alves HA,Dhert WJ,van Someren EP,Reinders MJ,van Blitterswijk CA,de Boer J

更新日期：2013-06-01 00:00:00

abstract：:The ability to restore heart function by replacement of diseased myocardium is one of the great challenges in biomaterials and regenerative medicine. Brown adipose derived stem cells (BADSCs) present a new source of cardiomyocytes to regenerate the myocardium after infarction. In this study, we explored an injectable ...

journal_title：Biomaterials

authors： Wang H,Shi J,Wang Y,Yin Y,Wang L,Liu J,Liu Z,Duan C,Zhu P,Wang C

更新日期：2014-04-01 00:00:00

abstract：:To explore molecular mechanism of mediation of adsorbed proteins to cell adhesion and growth on biomaterials, this study examined endothelial cell adhesion, morphology and viability on bare and titanium nitride (TiN) coated nickel titanium (NiTi) alloys and chitosan film firstly, and then identified the type and amoun...

journal_title：Biomaterials

authors： Yang D,Lü X,Hong Y,Xi T,Zhang D

更新日期：2013-07-01 00:00:00

abstract：:In this work, five self-assembled monolayers (SAMs) and three polymeric brushes with very low fibrinogen adsorption were prepared. The five SAMs are oligo(ethylene glycol) (OEG), phosphorylcholine (PC), oligo(phosphorylcholine) (OPC), and two mixed positively and negatively charged SAMs of SO(3)(-)/N(+)(CH(3))(3) (SA/...

journal_title：Biomaterials

authors： Zhang Z,Zhang M,Chen S,Horbett TA,Ratner BD,Jiang S

更新日期：2008-11-01 00:00:00

abstract：:To maintain enzymatic activity during long-term storage by conjugation with water-soluble 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers (PMPC-COOH) having various molecular weights with a carboxylic group on the terminal, such compounds were synthesized as a polymer modifier using a photoinduced living radic...

journal_title：Biomaterials

authors： Miyamoto D,Watanabe J,Ishihara K

更新日期：2004-01-01 00:00:00

abstract：:Introducing drugs into gene delivery systems to fabricate co-delivery systems for synergy therapy has become a promising strategy for tumor therapy. In this study, a dual responsive co-delivery system RHD/p53 was fabricated to enhance the antitumor efficacy with a low dose of doxorubicin (DOX). The reducible branched ...

journal_title：Biomaterials

authors： Chen S,Lei Q,Li SY,Qin SY,Jia HZ,Cheng YJ,Zhang XZ

更新日期：2016-06-01 00:00:00

abstract：:Nanocarriers possess advanced physicochemical properties that improve bioavailability, enhance cellular dynamics, and control targetability in drug delivery. In particular, dendritic polyglycerol is a promising new biocompatible scaffold for drug delivery. The present explores the structure-biocompatibility relationsh...

journal_title：Biomaterials

authors： Khandare J,Mohr A,Calderón M,Welker P,Licha K,Haag R

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVES:To analyze the biocompatibility of multifilament polyester (PET) meshes used for the implantation of auditory brainstem implants in a standardized Wistar rat model (n=29). METHODS:The physical properties of the meshes were examined during surgery. Using a modified plastic embedding, the local tissue reactio...

journal_title：Biomaterials

authors： Quester R,Hermanns B,Klosterhalfen B,Schröder R,Klug N

更新日期：2003-02-01 00:00:00

abstract：:Immobilization of biomolecules on surfaces enables both localization and retention of molecules at the cell-biomaterial interface. Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, biomolecular modification of these materials is challenging. In the pre...

journal_title：Biomaterials

authors： Puleo DA,Kissling RA,Sheu MS

更新日期：2002-05-01 00:00:00

abstract：:The influence of crystallization, upon heat treatment, on the properties of high-velocity oxy-fuel (HVOF) sprayed hydroxyapatite (HA) coatings was investigated. The characterization of the HA coating was performed by X-ray diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). Differential Scanning Calo...

journal_title：Biomaterials

authors： Li H,Khor KA,Cheang P

更新日期：2002-05-01 00:00:00

abstract：:The large surface area of highly porous titanium structures produced by additive manufacturing can be modified using biofunctionalizing surface treatments to improve the bone regeneration performance of these otherwise bioinert biomaterials. In this longitudinal study, we applied and compared three types of biofunctio...

journal_title：Biomaterials

authors： Amin Yavari S,van der Stok J,Chai YC,Wauthle R,Tahmasebi Birgani Z,Habibovic P,Mulier M,Schrooten J,Weinans H,Zadpoor AA

更新日期：2014-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosens...

journal_title：Biomaterials

authors： Lin LJ,Grimme JM,Sun J,Lu S,Gai L,Cropek DM,Wang Y

更新日期：2013-05-01 00:00:00

abstract：:Fibrillar type I collagen is nontoxic, biocompatible, and possesses considerable strength and stability. In a study of scaffolds for use in laminated tissue substitutes, we examined the properties of membranes made from air-dried hydrogels of collagen fibrils that were polymerized from native, monomeric collagen. Plan...

journal_title：Biomaterials

authors： Vernon RB,Gooden MD,Lara SL,Wight TN

更新日期：2005-04-01 00:00:00

abstract：:Poly(ε-caprolactone)-b-Poly(N-vinylpyrrolidone) (PCL-b-PVP) copolymers with different PVP block length were synthesized by xanthate-mediated reverse addition fragment transfer polymerization (RAFT) and the xanthate chain transfer agent on chain end was readily translated to hydroxy or aldehyde for conjugating various ...

journal_title：Biomaterials

authors： Zhu Z,Xie C,Liu Q,Zhen X,Zheng X,Wu W,Li R,Ding Y,Jiang X,Liu B

更新日期：2011-12-01 00:00:00

abstract：:Elasticity of cellular microenvironments strongly influences cell motility, phagocytosis, growth and differentiation. Currently, the relationship between the cell behaviour and matrix stiffness is being studied for cells seeded on planar substrates, however in three-dimensional (3D) microenvironments cells may experie...

journal_title：Biomaterials

authors： Kumachev A,Greener J,Tumarkin E,Eiser E,Zandstra PW,Kumacheva E

更新日期：2011-02-01 00:00:00

abstract：:One of the potential factors that may affect the results of mesenchymal stem cell (MSC)-based therapy is the age of donors and recipients. However, there have been no controlled studies to investigate the influence of skeletal maturity on the MSC-based repair of cartilage. The purpose of this study was to compare the ...

journal_title：Biomaterials

authors： Shimomura K,Ando W,Tateishi K,Nansai R,Fujie H,Hart DA,Kohda H,Kita K,Kanamoto T,Mae T,Nakata K,Shino K,Yoshikawa H,Nakamura N

更新日期：2010-11-01 00:00:00

abstract：:To fully understand biological behavior in vitro often dictates that oxygen be reported at either a local or a cellular level. Oxygen sensors based on the luminescent quenching of a specific form of electrospun fiber were developed for measurement of both gaseous and dissolved oxygen concentrations. Electrospinning wa...

journal_title：Biomaterials

authors： Xue R,Nelson MT,Teixeira SA,Viapiano MS,Lannutti JJ

更新日期：2016-01-01 00:00:00

abstract：:Coralline hydroxyapatite ceramics alone (control) and the ceramics combined with rat marrow cells were implanted subcutaneously in the backs of syngeneic Fischer rats and harvested at 1,2,3,4,6,8 and 24 wk after surgery. None of the control ceramics (without marrow) showed bone formation. However, ceramics combined wi...

journal_title：Biomaterials

authors： Okumura M,Ohgushi H,Tamai S

更新日期：1991-05-01 00:00:00

abstract：:Direct delivery of proteins to the cytosol of cells holds tremendous potential in biological and medical applications. Engineering vehicles for escorting proteins to the cytosol in a controlled release fashion has thus generated considerable interest. We report here the preparation of redox-responsive single-protein n...

journal_title：Biomaterials

authors： Zhao M,Biswas A,Hu B,Joo KI,Wang P,Gu Z,Tang Y

更新日期：2011-08-01 00:00:00

abstract：:Titanium can form a bone-like apatite layer on its surface in SBF when it is treated in NaOH. When pre-treated titanium is exposed to SBF, the alkali ions are released from the surface into the surrounding fluid. The Na+ ions increase the degree of supersaturation of the soaking solution with respect to apatite by inc...

journal_title：Biomaterials

authors： Jonásová L,Müller FA,Helebrant A,Strnad J,Greil P

更新日期：2002-08-01 00:00:00

abstract：:A technique for preparing micropatterns and gradients of proteins on polymeric substrates has been developed in this work. Peroxides were generated on the substrate surface by UV preirradiation and they initiated graft polymerization of acrylic acid (AA) onto the surface upon a second UV irradiation. Micropatterns and...

journal_title：Biomaterials

authors： Li B,Ma Y,Wang S,Moran PM

更新日期：2005-05-01 00:00:00

abstract：:Despite the promise for stem cell-based tissue engineering for regenerative therapy, slow and insufficient vascularization of large tissue constructs negatively impacts the survival and function of these transplanted cells. A combination of channeled porous silk scaffolds and prevascularization with endothelial cells ...

journal_title：Biomaterials

authors： Zhang W,Wray LS,Rnjak-Kovacina J,Xu L,Zou D,Wang S,Zhang M,Dong J,Li G,Kaplan DL,Jiang X

更新日期：2015-07-01 00:00:00

abstract：:Bone defects caused by fractures or cancer-mediated destruction are debilitating. Chitosan is commonly used in scaffold matrices for bone healing, but rarely as a free drug. We demonstrate that free chitosan promotes osteoblast proliferation and osteogenesis in mesenchymal stem cells, increases osteopontin and collage...

journal_title：Biomaterials

authors： Tan ML,Shao P,Friedhuber AM,van Moorst M,Elahy M,Indumathy S,Dunstan DE,Wei Y,Dass CR

更新日期：2014-09-01 00:00:00

abstract：:The systemic administration of immunosuppressive and anti-inflammatory drugs is routinely employed in organ transplantation to minimize graft rejection and improve graft survival. Localized drug delivery has the potential to improve transplant outcomes by providing sustained exposure to efficacious drug concentrations...

journal_title：Biomaterials

authors： Chang CA,Akinbobuyi B,Quintana JM,Yoshimatsu G,Naziruddin B,Kane RR

更新日期：2018-03-01 00:00:00

abstract：:Barium titanate (BaTiO3; BTO) is ferroelectric and piezoelectric after poling treatment. In this study, the bioactivity of BTO was investigated after a poling treatment by examining the formation of crystal growth on specimen surfaces in vitro. Negatively charged BTO surfaces showed calcium phosphate (Ca-P) crystal gr...

journal_title：Biomaterials

authors： Park YJ,Hwang KS,Song JE,Ong JL,Rawls HR

更新日期：2002-09-01 00:00:00

abstract：:This animal study (domestic pig) examined the bone formation after filling defined defects with autogenous bone or a collagen lyophilisat in combination with Platelet-rich-plasma (PRP) by evaluating bone matrix proteins. Six groups, both materials with and without PRP in two concentrations (+ 1, + 2) were compared to ...

journal_title：Biomaterials

authors： Thorwarth M,Rupprecht S,Falk S,Felszeghy E,Wiltfang J,Schlegel KA

更新日期：2005-05-01 00:00:00

abstract：:The generation of effective tissue engineered bone grafts requires efficient exchange of nutrients and mechanical stimulus. Bioreactors provide a manner in which this can be achieved. We have recently developed a biaxial rotating bioreactor with efficient fluidics through in-silico modeling. Here we investigated its p...

journal_title：Biomaterials

authors： Zhang ZY,Teoh SH,Chong WS,Foo TT,Chng YC,Choolani M,Chan J

更新日期：2009-05-01 00:00:00

abstract：:The polymer poly-N-acetylglucosamine (pGlcNAc) containing fiber material is becoming increasingly important as a topical agent for hemostasis at wound sites. The pGlcNAc polymeric fiber provides hemostasis through redundant mechanisms that include platelet activation for fibrin network formation. The research presente...

journal_title：Biomaterials

authors： Fischer TH,Thatte HS,Nichols TC,Bender-Neal DE,Bellinger AD,Vournakis JN

更新日期：2005-09-01 00:00:00