Neural differentiation of pluripotent cells in 3D alginate-based cultures.

abstract：:This study was undertaken to evaluate the role of collagen matrix to enhance platelet-rich plasma (PRP) effects on pro-inflammatory cytokine-induced arthritic model. We have previously demonstrated the highly regenerative roles of PRP to restore disc degeneration and osteoporosis. In this study, PRP modulated by colla...

journal_title：Biomaterials

authors： Wu CC,Chen WH,Zao B,Lai PL,Lin TC,Lo HY,Shieh YH,Wu CH,Deng WP

更新日期：2011-09-01 00:00:00

abstract：:Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be buried inside the random polymer coil and not exposed to b...

journal_title：Biomaterials

authors： Li L,Yang Q,Zhou Z,Zhong J,Huang Y

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Carboplatin, an antineoplastic agent, binds DNA and enhances radiotherapy (RT) effects. Carboplatin-loaded hydrogel (oxidized hyaluronic acid/adipic acid dihydrazide) enables the sustained drug release and facilitates the synergistic effect with RT. PURPOSE:We investigated the effectiveness and convenience ...

journal_title：Biomaterials

authors： Liang HT,Lai XS,Wei MF,Lu SH,Wen WF,Kuo SH,Chen CM,Tseng WI,Lin FH

更新日期：2018-01-01 00:00:00

abstract：:Single-stranded oligonucleotide-conjugated lipids (ssDNA-PEG-lipids) that associate with the cell membrane confer to the cell an artificial adhesive capability via sequence-specific hybridization to complementary oligonucleotides, forming bonds of double stranded oligonucleotides (dsDNA). Such artificial tethers permi...

journal_title：Biomaterials

authors： Hoffecker IT,Takemoto N,Arima Y,Iwata H

更新日期：2015-01-01 00:00:00

abstract：:We have investigated the interface between bone and hydroxyapatite (HA) chronically implanted in man. By light microscopy, HA appeared to bind directly to bone without intervening fibrous tissue. By transmission electron microscopy, two patterns were noted: (1) HA either bound directly to bone; or (2) electron-dense m...

journal_title：Biomaterials

authors： Oguchi H,Ishikawa K,Mizoue K,Seto K,Eguchi G

更新日期：1995-01-01 00:00:00

abstract：:The objective of this study is to develop a carrier for the controlled release of bone morphogenetic protein-2 (BMP-2) suitable for enhancement of the bone regeneration activity. Hydrogels with different water contents were prepared through glutaraldehyde crosslinking of gelatin with an isoelectric point of 9.0 under ...

journal_title：Biomaterials

authors： Yamamoto M,Takahashi Y,Tabata Y

更新日期：2003-11-01 00:00:00

abstract：:A bilayer artificial skin composed of a silicone sheet and a collagen sponge sheet was developed by us in 1986, modifying Yannas and Burke's technique. It was used in experimental animals and clinically, both with success; but the artificial skin was inconvenient for clinical use in terms of disinfection and preservat...

journal_title：Biomaterials

authors： Matsuda K,Suzuki S,Isshiki N,Ikada Y

更新日期：1993-10-01 00:00:00

abstract：:Topographic features can modulate cell behaviours such as proliferation, migration, differentiation and apoptosis. Biochemical mechanotransduction implies the conversion of mechanical forces (e.g. changes in cell spreading and morphology from changing surface topography) into biochemical signal via biomolecules. Still...

journal_title：Biomaterials

authors： Kantawong F,Burgess KE,Jayawardena K,Hart A,Burchmore RJ,Gadegaard N,Oreffo RO,Dalby MJ

更新日期：2009-09-01 00:00:00

abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

journal_title：Biomaterials

authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

更新日期：1996-01-01 00:00:00

abstract：:In vivo and in vitro degradation of high molecular weight poly(L-lactide) used for internal bone fixation has been investigated. Within 3 months as-polymerized, microporous PLLA (Mv = 6.8-9.5 X 10(5] exhibited a massive strength-loss (sigma b = 68-75 MPa to sigma b = 4 MPa) and decrease of Mv (90-95%). At week 39, the...

journal_title：Biomaterials

authors： Leenslag JW,Pennings AJ,Bos RR,Rozema FR,Boering G

更新日期：1987-07-01 00:00:00

abstract：:We recently showed that the highly organized architecture of the corneal stroma could be reproduced using scaffolds consisting of orthogonally aligned multilayers of collagen fibrils prepared using a high magnetic field. Here we show that such scaffolds permit the reconstruction in vitro of human hemi-corneas (stroma ...

journal_title：Biomaterials

authors： Builles N,Janin-Manificat H,Malbouyres M,Justin V,Rovère MR,Pellegrini G,Torbet J,Hulmes DJ,Burillon C,Damour O,Ruggiero F

更新日期：2010-11-01 00:00:00

abstract：:Microfabricated devices possessing magnetic properties are of great utility in bioanalytical microdevices due to their controlled manipulation with external magnets. Current methods for creating magnetic microdevices yield a low-transparency material preventing light microscopy-based inspection of biological specimens...

journal_title：Biomaterials

authors： Gach PC,Sims CE,Allbritton NL

更新日期：2010-11-01 00:00:00

abstract：:The engineering of living tissues in vivo requires new concepts in cell culture technology. In contrast to conventional cell cultures, the development of tissues depends on a three-dimensional arrangement of cells and the formation or synthesis of an appropriate extracellular matrix. Special emphasis is given to the m...

journal_title：Biomaterials

authors： Sittinger M,Bujia J,Rotter N,Reitzel D,Minuth WW,Burmester GR

更新日期：1996-02-01 00:00:00

abstract：:Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have designed a polymeric carrier system to deliver nitric oxide locoregionally to tumor...

journal_title：Biomaterials

authors： Duan S,Cai S,Yang Q,Forrest ML

更新日期：2012-04-01 00:00:00

abstract：:In the stem-cell niche, the extracellular matrix (ECM) serves as a structural support that additionally provides stem cells with signals that contribute to the regulation of stem-cell function, via reciprocal interactions between cells and components of the ECM. Recently, cell-derived ECMs have emerged as in vitro cel...

journal_title：Biomaterials

authors： Ragelle H,Naba A,Larson BL,Zhou F,Prijić M,Whittaker CA,Del Rosario A,Langer R,Hynes RO,Anderson DG

更新日期：2017-06-01 00:00:00

abstract：:Angiogenesis is a complex multistage process involving multiple factors and numerous cells. The use of the Chorioallantoic Membrane (CAM) assay is well documented as a method to investigate angiogenesis. This technique is ideal for screening samples, but requires an objective analysis technique. The angiogenic respons...

journal_title：Biomaterials

authors： Oates M,Chen R,Duncan M,Hunt JA

更新日期：2007-09-01 00:00:00

abstract：:Si, Mg-substituted hydroxyapatites, alone and co-substituted, have been prepared to obtain biomaterials having an improved biocompatibility. From FT-IR, XRD and ICP analyses, it was confirmed that single phases of hydroxyapatite substituted by Si alone or co-substituted by Si, Mg. The XRD data indicated the absence of...

journal_title：Biomaterials

authors： Kim SR,Lee JH,Kim YT,Riu DH,Jung SJ,Lee YJ,Chung SC,Kim YH

更新日期：2003-04-01 00:00:00

abstract：:The biophysical properties of extracellular matrices (ECM) are known to regulate cell behavior, however decoupling cell behavior changes due to the relative contributions of material microstructure versus biomechanics or nutrient permeability remains challenging, especially within complex, multi-material matrices. We ...

journal_title：Biomaterials

authors： Dubbin K,Robertson C,Hinckley A,Alvarado JA,Gilmore SF,Hynes WF,Wheeler EK,Moya ML

更新日期：2020-08-01 00:00:00

abstract：:Current synthetic vascular grafts possess a significant mechanical mismatch compared to the native vasculature and do not permit endothelialization; both of these deficiencies contribute to the relatively high rate of failure of many synthetic grafts. In this communication, we report the modification of polyurethane (...

journal_title：Biomaterials

authors： Chuang TW,Masters KS

更新日期：2009-10-01 00:00:00

abstract：:Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for ...

journal_title：Biomaterials

authors： Song R,Zhang M,Liu Y,Cui Z,Zhang H,Tang Z,Chen X,Wu H,Yao Z,He M,Bu W

更新日期：2018-08-01 00:00:00

abstract：:Novel acid-base reaction cements have been developed for use as controlled release formulations. Many new ones have been discovered and assessed; these include those which are capable of releasing copper, cobalt or selenium singly or in combination. A selection was made of the most suitable formulations for this purpo...

journal_title：Biomaterials

authors： Prosser HJ,Wilson AD,Groffman DM,Brookman PJ,Allen WM,Gleed PT,Manston R,Sansom BF

更新日期：1986-03-01 00:00:00

abstract：:An oxidizing treatment of carbon fibres in boiling nitric acid leads to significant changes in the chemical state of their surface. As a result of the chemical treatment on a hydrophobic carbon surface, hydrophilic domains are formed and phenolic, carbonyl and carboxyl groups appear. In this work the intensity of phag...

journal_title：Biomaterials

authors： Czajkowska B,Błazewicz M

更新日期：1997-01-01 00:00:00

abstract：:We studied three different types of scaffolds, encapsulating bone morphogenetic protein-2 (BMP-2) plasmid, in terms of their performances in bone regeneration in nude mice. The plasmid was loaded into fibrous matrices in three different ways: coating of naked DNA (Group A) or DNA/chitosan nanoparticles (Group B) onto ...

journal_title：Biomaterials

authors： Nie H,Ho ML,Wang CK,Wang CH,Fu YC

更新日期：2009-02-01 00:00:00

abstract：:Chitosan-silica xerogel hybrid membranes were fabricated using a sol-gel process and their potential applications in guided bone regeneration (GBR) were investigated in terms of their in vitro cellular activity and in vivo bone regeneration ability. TEM observation revealed that the silica xerogel was dispersed in the...

journal_title：Biomaterials

authors： Lee EJ,Shin DS,Kim HE,Kim HW,Koh YH,Jang JH

更新日期：2009-02-01 00:00:00

abstract：:A simple approach to the mechanical modulation of layer-by-layer (LbL) films is through manipulation of the film assembly. Here, we report results based on altering the salt concentration during film assembly and its effect on film rigidity. Based on changes in film rigidity, cell adhesion characteristics and transfec...

journal_title：Biomaterials

authors： Blacklock J,Vetter A,Lankenau A,Oupický D,Möhwald H

更新日期：2010-09-01 00:00:00

abstract：:The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric animal-plant tissues during dermal regeneration. In this work,...

journal_title：Biomaterials

authors： Chávez MN,Schenck TL,Hopfner U,Centeno-Cerdas C,Somlai-Schweiger I,Schwarz C,Machens HG,Heikenwalder M,Bono MR,Allende ML,Nickelsen J,Egaña JT

更新日期：2016-01-01 00:00:00

abstract：:The nanoscale materials properties of bone apatite crystals have been implicated in breast cancer bone metastasis and their interactions with extracellular matrix proteins are likely involved. In this study, we used geologic hydroxyapatite (HAP, Ca10(PO4)6(OH)2), closely related to bone apatite, to investigate how HAP...

journal_title：Biomaterials

authors： Wu F,Chen W,Gillis B,Fischbach C,Estroff LA,Gourdon D

更新日期：2017-02-01 00:00:00

abstract：:Bioencapsulation involves the envelopment of tissues or biological active substances in semipermeable membranes. Bioencapsulation has been shown to be efficacious in mimicking the cell's natural environment and thereby improves the efficiency of production of different metabolites and therapeutic agents. The field of ...

journal_title：Biomaterials

authors： de Vos P,Bucko M,Gemeiner P,Navrátil M,Svitel J,Faas M,Strand BL,Skjak-Braek G,Morch YA,Vikartovská A,Lacík I,Kolláriková G,Orive G,Poncelet D,Pedraz JL,Ansorge-Schumacher MB

更新日期：2009-05-01 00:00:00

abstract：:B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in specialized regions of lymph nodes and spleens, called germinal cen...

journal_title：Biomaterials

authors： Roh KH,Song HW,Pradhan P,Bai K,Bohannon CD,Dale G,Leleux J,Jacob J,Roy K

更新日期：2018-05-01 00:00:00

abstract：:To maintain enzymatic activity during long-term storage by conjugation with water-soluble 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers (PMPC-COOH) having various molecular weights with a carboxylic group on the terminal, such compounds were synthesized as a polymer modifier using a photoinduced living radic...

journal_title：Biomaterials

authors： Miyamoto D,Watanabe J,Ishihara K

更新日期：2004-01-01 00:00:00