Abstract:
:Non-covalent interactions are often regarded as insufficient to construct macroscopic materials of substantial integrity and cohesion. However, the low binding energy of such reversible interactions can be compensated by increasing their number to work in concert to create strong materials. Here we present the successful development of an injectable, cohesive nanocomposite hydrogel based on reversible bonds between calcium phosphate nanoparticles and bisphosphonate-functionalized hyaluronic acid. These nanocomposites display a capacity for self-healing as well as adhesiveness to mineral surfaces such as enamel and hydroxyapatite. Most importantly, these non-covalently cross-linked composites are surprisingly robust yet biodegradable upon extensive in vitro and in vivo testing and show bone interactive capacity evidenced by bone ingrowth into material remnants. The herein presented method provides a new methodology for constructing nanoscale composites for biomedical applications, which owe their integrity to reversible bonds.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Nejadnik MR,Yang X,Bongio M,Alghamdi HS,van den Beucken JJ,Huysmans MC,Jansen JA,Hilborn J,Ossipov D,Leeuwenburgh SCdoi
10.1016/j.biomaterials.2014.05.003subject
Has Abstractpub_date
2014-08-01 00:00:00pages
6918-29issue
25eissn
0142-9612issn
1878-5905pii
S0142-9612(14)00546-8journal_volume
35pub_type
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