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The effects of a functionally-graded scaffold and bone marrow-derived mononuclear cells on steroid-induced femoral head osteonecrosis.

Abstract：

:Osteonecrosis of the femoral head (ONFH) is a debilitating disease that may progress to femoral head collapse and subsequently, degenerative arthritis. Although injection of bone marrow-derived mononuclear cells (BMMCs) is often performed with core decompression (CD) in the early stage of ONFH, these treatments are not always effective in prevention of disease progression and femoral head collapse. We previously described a novel 3D printed, customized functionally-graded scaffold (FGS) that improved bone growth in the femoral head after CD in a normal healthy rabbit, by providing structural and mechanical guidance. The present study demonstrates similar results of the FGS in a rabbit steroid-induced osteonecrosis model. Furthermore, the injection of BMMCs into the CD decreased the osteonecrotic area in the femoral head. Thus, the combination of FGS and BMMC provides a new therapy modality that may improve the outcome of CD for early stage of ONFH by providing both enhanced biological and biomechanical cues to promote bone regeneration in the osteonecrotic area.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Maruyama M,Nabeshima A,Pan CC,Behn AW,Thio T,Lin T,Pajarinen J,Kawai T,Takagi M,Goodman SB,Yang YP

doi

10.1016/j.biomaterials.2018.09.030

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

39-46

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(18)30667-7

journal_volume

187

pub_type

杂志文章

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