Abstract：
:The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(butadiene)-b-poly(ethylene glycol) (PBD-PEO), as emulsifiers. The size, stability and cell viability was investigated for all stabilized emulsions. Three emulsions stabilized with either lipids or PBD-PEO were subsequently tested in vivo as a CT blood pool contrast agent in mice. While the lipid-stabilized emulsions turned out unstable in vivo, polymer-stabilized emulsions performed well in vivo. In blood, a contrast enhancement of 220 Hounsfield Units (HU) was measured directly after intravenous administration of 520 mg I/kg. The blood circulation half-life of a PBD-PEO stabilized emulsion was approximately 3 h and no noticeable in vivo toxicity was observed. These results show the potential of above emulsions for use as blood pool agents in contrast enhanced CT imaging.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
de Vries A,Custers E,Lub J,van den Bosch S,Nicolay K,Grüll Hdoi
10.1016/j.biomaterials.2010.04.056subject
Has Abstractpub_date
2010-09-01 00:00:00pages
6537-44issue
25eissn
0142-9612issn
1878-5905pii
S0142-9612(10)00572-7journal_volume
31pub_type
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