Abstract:
:The aim of the present study was to evaluate the potential of acellular dermal matrix as a carrier for delivery of stem cells to the site of soft tissue defect in a murine skin injury model and to determine the potential of stem cells delivered via such an approach to successfully engraft, survive and differentiate locally. We showed that adipose-derived stem cells delivered via this matrix survived after in vivo engraftment, spontaneously differentiated along vascular endothelial, fibroblastic and epidermal epithelial lineages and significantly improved wound healing. Furthermore, an organ survey for transplanted cells showed no evidence of a systemic distribution beyond the cutaneous wound site, indicating that the adipose-derived stem cell-dermal matrix construct provides a novel and effective method for anatomically focused cellular therapy. In conclusion, stem cell-seeded dermal matrix is an effective means for targeted in vivo cell delivery for enhanced soft tissue regeneration.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Altman AM,Matthias N,Yan Y,Song YH,Bai X,Chiu ES,Slakey DP,Alt EUdoi
10.1016/j.biomaterials.2007.11.026subject
Has Abstractpub_date
2008-04-01 00:00:00pages
1431-42issue
10eissn
0142-9612issn
1878-5905pii
S0142-9612(07)00956-8journal_volume
29pub_type
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