The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel.

abstract：:Wounded tissues and cells may be treated with growth factors and specific genes for the purpose of tissue repair and regeneration. To deliver specific genes into tissues and cells, this study presents the use of fabricated poly (DL-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) complexed with the cationic polymer...

journal_title：Biomaterials

authors： Park JS,Yang HN,Woo DG,Jeon SY,Park KH

更新日期：2013-01-01 00:00:00

abstract：:Photosensitizers with aggregation-induced emission (AIE) characteristics are of great interest for cancer theranostics involving both fluorescence imaging and photodynamic therapy (PDT). However, in the purpose of clinical trials of PDT, the development of prominent drug delivery systems for boosting the PDT efficienc...

journal_title：Biomaterials

authors： Li Y,Wu Q,Kang M,Song N,Wang D,Tang BZ

更新日期：2020-02-01 00:00:00

abstract：:The biopolymer DNA allows to create nanoscale, biocompatible structures, which can be designed in a target-specific and stimuli-responsive manner. DNA carrier systems with these characteristics hold a great potential for nanomedical applications, such as for the treatment of inflammatory diseases. Here we used a DNA-b...

journal_title：Biomaterials

authors： Sellner S,Kocabey S,Zhang T,Nekolla K,Hutten S,Krombach F,Liedl T,Rehberg M

更新日期：2017-07-01 00:00:00

abstract：:Microcomputed tomography (micro-CT) is increasingly being used to analyze the three-dimensional structure and architecture of microvascular networks. Therefore we have evaluated a micro-CT analysis of VEGF-induced vessel ingrowth into a porous polyurethane scaffold through comparison with analyses by CD31 immunohistoc...

journal_title：Biomaterials

authors： Schmidt C,Bezuidenhout D,Beck M,Van der Merwe E,Zilla P,Davies N

更新日期：2009-10-01 00:00:00

abstract：:Cutaneous melanoma is an increasingly common and potentially lethal malignancy of melanocytes, the melanin producing cells normally located in the basal layer of the skin epidermis. Despite major advances in cancer chemotherapeutics and immunotherapy, the success in treating metastatic melanoma remains poor. The notio...

journal_title：Biomaterials

authors： Chandrasekaran S,DeLouise LA

更新日期：2011-12-01 00:00:00

abstract：:To develop artificial materials for prolonged use in the vascular system, the complicated process of surface-induced thrombosis needs to be better understood. Steroidal hormones have a profound role in thrombosis and haemostasis, although adequate studies are not available to demonstrate their part in the thromboembol...

journal_title：Biomaterials

authors： Sharma CP,Chandy T

更新日期：1989-11-01 00:00:00

abstract：:This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a control group. The c...

journal_title：Biomaterials

authors： Thorwarth M,Schultze-Mosgau S,Wehrhan F,Kessler P,Srour S,Wiltfang J,Andreas Schlegel K

更新日期：2005-10-01 00:00:00

abstract：:To avoid the overheating effect of excitation light and improve the efficacy of photodynamic therapy (PDT) of upconversion nanoplatform, a novel nanoprobe based on 808 nm-excited upconversion nanocomposites (T-UCNPs@Ce6@mSiO2) with low heating effect and deep penetration has been successfully constructed for targeted ...

journal_title：Biomaterials

authors： Zeng L,Pan Y,Zou R,Zhang J,Tian Y,Teng Z,Wang S,Ren W,Xiao X,Zhang J,Zhang L,Li A,Lu G,Wu A

更新日期：2016-10-01 00:00:00

abstract：:A synthetic peptide, Gly-Arg-Gly-Asp-Ser-Pro-Lys (GRGDSPK), which includes the cell-adhesive region of fibronectin, Arg-Gly-Asp (RGD), was covalently bound to a dialdehyde starch (DAS) coating on a polymer surface by reductive amination. The GRGDSPK/DAS-coated surface was characterized by atomic force microscopy (AFM)...

journal_title：Biomaterials

authors： Holland J,Hersh L,Bryhan M,Onyiriuka E,Ziegler L

更新日期：1996-11-01 00:00:00

abstract：:Low molecular weight polyurethanes with sites for metal complexation were synthesized. The -SO(2) and the -COOH groups were incorporated into the polyurethane chain by the reactions of tri-functional monomers, 4,4'-bis(hydroxyphenyl)sulfone and 4,4'-bis(hydroxyphenyl) valeric acid with hexa-methylene di-isocyanate (HM...

journal_title：Biomaterials

authors： Acharya V,Prabha CR,Narayanamurthy C

更新日期：2004-08-01 00:00:00

abstract：:A genetically encoded Förster Resonance Energy Transfer (FRET)-based biosensor that continuously monitors matrix metalloproteinase 9 (MMP-9) activity was developed. MMP-9 is an extracellularly acting endopeptidase with a prominent role in development, learning and memory, cancer metastasis, and stroke. To assess the b...

journal_title：Biomaterials

authors： Stawarski M,Rutkowska-Wlodarczyk I,Zeug A,Bijata M,Madej H,Kaczmarek L,Wlodarczyk J

更新日期：2014-02-01 00:00:00

abstract：:A 29 amino-acid peptide derived from the rabies virus glycoprotein (RVG29) was exploited as a ligand for efficient brain-targeting gene delivery. RVG29 was modified on polyamidoamine dendrimers (PAMAM) through bifunctional PEG, then complexed with DNA, yielding PAMAM-PEG-RVG29/DNA nanoparticles (NPs). The NPs were obs...

journal_title：Biomaterials

authors： Liu Y,Huang R,Han L,Ke W,Shao K,Ye L,Lou J,Jiang C

更新日期：2009-09-01 00:00:00

abstract：:Medical implants used in oral and orthopaedic surgery are mainly produced from titanium. Their biological behaviour, e.g. osseointegration, essentially depends on both the chemical composition and the morphology of the surface. Modifications achieved by excimer laser irradiation of titanium samples were investigated i...

journal_title：Biomaterials

authors： Bereznai M,Pelsöczi I,Tóth Z,Turzó K,Radnai M,Bor Z,Fazekas A

更新日期：2003-10-01 00:00:00

abstract：:Current prosthetic small diameter vascular grafts show poor long-term patency rates, leading to the pursuit of a biological alternative. Hyaff-11 is a hyaluronan-based biodegradable polymer developed for tissue-engineering applications. This study aimed to determine whether human vascular endothelial cells attach to H...

journal_title：Biomaterials

authors： Turner NJ,Kielty CM,Walker MG,Canfield AE

更新日期：2004-12-01 00:00:00

abstract：:Targeting delivery system has been widely used in packaging drugs for medical therapies attributed to its high efficiency and efficacy. A Traditional Chinese Medicine (TCM) formula consisting of Herba Epimedii has previously been shown to effectively treat postmenopausal osteoporosis. We have subsequently found that i...

journal_title：Biomaterials

authors： Huang L,Wang X,Cao H,Li L,Chow DH,Tian L,Wu H,Zhang J,Wang N,Zheng L,Yao X,Yang Z,Qin L

更新日期：2018-11-01 00:00:00

abstract：:Bioprosthetic heart valves fail as the result of two simultaneous processes: structural deterioration and calcification. Leaflet deterioration and perforation have been correlated with regions of highest stress in the tissue. The failures have long been assumed to be due to simple mechanical fatigue of the collagen fi...

journal_title：Biomaterials

authors： Ellsmere JC,Khanna RA,Lee JM

更新日期：1999-06-01 00:00:00

abstract：:Decellularized extracellular matrices (ECM) from in vitro cell cultures can serve as in vivo-like matrix scaffolds for modulating cell-ECM interactions. Macromolecular crowding (MMC), the supplementation of synthetic or naturally occurring molecules resulting in excluded volume effects (EVE), has been demonstrated to ...

journal_title：Biomaterials

authors： Prewitz MC,Stißel A,Friedrichs J,Träber N,Vogler S,Bornhäuser M,Werner C

更新日期：2015-12-01 00:00:00

abstract：:The aminohexyl derivative of the copolymer of 2-hydroxyethyl methacrylate and ethylene dimethacrylate (p(HEMA)-Hex) in the form of regular spherical particles was used as a polymeric carrier for chemically sorbed methotrexate (MTX). The effect of the washed p(HEMA)-Hex-MTX carrier on the morphological structure of don...

journal_title：Biomaterials

authors： Horák D,Svec F,Adamyan A,Titova M,Skuba N,Voronkova O,Trostenyuk N,Vishnevskii V,Gumargalieva K

更新日期：1992-01-01 00:00:00

abstract：:This study was designed to examine the adhesion, proliferation, and morphology of chondrocytes on new scaffolds; and to examine these cells histologically for the ability of the chondrocytes to maintain chondrogenic properties after subcutaneous implantation into nude mice. Both 75:25 poly (L-lactide-co-epsilon-caprol...

journal_title：Biomaterials

authors： Honda M,Morikawa N,Hata K,Yada T,Morita S,Ueda M,Kimata K

更新日期：2003-09-01 00:00:00

abstract：:Disruption of peripheral nerves due to trauma is a frequently occurring clinical problem. Gaps in the nerve are bridged by guiding the regenerating nerves along autologous grafts or artificial guides. This review gives an overview on the different methods of nerve repair techniques. Conventional suturing techniques ar...

journal_title：Biomaterials

authors： IJkema-Paassen J,Jansen K,Gramsbergen A,Meek MF

更新日期：2004-04-01 00:00:00

abstract：:We investigated the hypothesis that immobilizing TGF-β1 within fibrin hydrogels may act in synergy with cyclic mechanical stimulation to enhance the properties of vascular grafts. To this end, we engineered a fusion TGF-β1 protein that can covalently anchor to fibrin during polymerization upon the action of factor XII...

journal_title：Biomaterials

authors： Liang MS,Koobatian M,Lei P,Swartz DD,Andreadis ST

更新日期：2013-10-01 00:00:00

abstract：:Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen ...

journal_title：Biomaterials

authors： Kumosa LS,Routh TL,Lin JT,Lucisano JY,Gough DA

更新日期：2014-09-01 00:00:00

abstract：:Local tumor therapy through injectable biodegradable hydrogels with controlled drug release has attracted much attention recently, due to their easy operation, low side effect and efficiency. However, most of the reported therapeutic hydrogel system showed a lack of biodegradation tracking and tumor environment-respon...

journal_title：Biomaterials

authors： Wang M,Chen M,Niu W,Winston DD,Cheng W,Lei B

更新日期：2020-12-01 00:00:00

abstract：:Doxorubicin (DOX)-loaded glycyrrhetinic acid (GA)-modified alginate (ALG) nanoparticles (DOX/GA-ALG NPs) were prepared for targeting therapy of liver cancer. This study focused on the biodistribution of DOX/GA-ALG NPs in Kunming mice as well as their antitumor activity against liver tumors in situ and side effects. Th...

journal_title：Biomaterials

authors： Zhang C,Wang W,Liu T,Wu Y,Guo H,Wang P,Tian Q,Wang Y,Yuan Z

更新日期：2012-03-01 00:00:00

abstract：:This study was undertaken to investigate the relative importance of a hydroxyapatite (HA) coating and the macrotexture of titanium implants to the quality of bony ingrowth and fixation. Various types of titanium cylinders were implanted into the cancellous bone of the intercondylar region of the distal femur of the do...

journal_title：Biomaterials

authors： Hayashi K,Mashima T,Uenoyama K

更新日期：1999-01-01 00:00:00

abstract：:Here, we demonstrated dimethyldioctadecylammonium bromide (DODAB), a cationic lipid, bilayer coated Au nanoparticles (AuNPs) could efficiently deliver two types of plasmid DNA into human embryonic kidney cells (HEK 293) in the presence of serum. The transfection efficiency of AuNPs was about five times higher than tha...

journal_title：Biomaterials

authors： Li P,Li D,Zhang L,Li G,Wang E

更新日期：2008-09-01 00:00:00

abstract：:Matrix anisotropy is important for long term in vivo functionality. However, it is not fully understood how to guide matrix anisotropy in vitro. Experiments suggest actin-mediated cell traction contributes. Although F-actin in 2D displays a stretch-avoidance response, 3D data are lacking. We questioned how cyclic stre...

journal_title：Biomaterials

authors： Foolen J,Deshpande VS,Kanters FM,Baaijens FP

更新日期：2012-10-01 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeat (CRISPR) systems have a wide variety of applications besides precise genome editing. In particular, the CRISPR/dCas9 system can be used to control specific gene expression by CRISPR activation (CRISPRa) or interference (CRISPRi). However, the safety concerns...

journal_title：Biomaterials

authors： Zhang K,Chooi WH,Liu S,Chin JS,Murray A,Nizetic D,Cheng D,Chew SY

更新日期：2020-10-01 00:00:00

abstract：:Metabolic glycoengineering is a powerful technique that can introduce various chemical groups to cellular glycan by treatment of unnatural monosaccharide. Particularly, this technique has enabled many challenging trials for molecular imaging in combination with click chemistry, which provides fast and specific chemica...

journal_title：Biomaterials

authors： Yoon HY,Koo H,Kim K,Kwon IC

更新日期：2017-07-01 00:00:00

abstract：:As radio- and chemotherapy-based cancer treatments affect both tumors and healthy tissue, cancer immunotherapy attempts to specifically enhance the natural immune response to tumor cells. In mouse models of cancer, we tested uniform dimercaptosuccinic acid (DMSA)-coated monodisperse magnetic nanoparticles as a deliver...

journal_title：Biomaterials

authors： Mejías R,Pérez-Yagüe S,Gutiérrez L,Cabrera LI,Spada R,Acedo P,Serna CJ,Lázaro FJ,Villanueva A,Morales Mdel P,Barber DF

更新日期：2011-04-01 00:00:00