当前位置： SCI文献检索 > BIOMATERIALS期刊下所有文献 > PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid.

PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid.

Abstract：

:There is a broad interest in the development of nanoparticles (NPs) carrying on their surface carbohydrates such as sialic acids. It is known that these carbohydrates influence the biological and physical properties of biopharmaceutical proteins and living cells. Macromolecular compounds containing these carbohydrates showed an anti-recognition effect, exert an antiviral effect and also are able to be recognized by the cell surface of some kind of cancer cells. Thus, in the present research we performed two different approaches in order to obtain polymeric (poly(D,L-lactide-co-glycolide), PLGA) NPs surface decorated with the sialic acid N-acetylneuraminic acid (Neu5Ac). The first strategy that has been followed is based on the derivatization of the polyester PLGA with the thioderivative of Neu5Ac, starting material for the preparation of the NPs; the second is based on the synthesis of compounds potentially able to insert their lipophilic moiety into the underivatized PLGA NPs during their preparation, and to display their hydrophilic moiety (Neu5Ac) on their surface. The first approach allowed the obtainment of NPs surface decorated with Neu5Ac, as evidenced by ESCA spectroscopy and interaction with the lectin Wheat Germ Agglutinin. Moreover, a formulation of these NPs suitable for in vitro assays showed that they are phagocytosed by human monocytes with an apparently different mechanism with respect of those made of underivatized PLGA. The second strategy led to NPs in which their surface appears to be very different with respect to the NPs obtained following the first strategy, with the carboxylic groups of Neu5Ac markedly shielded. Thus, the new Neu5Ac-modified PLGA polyester represent a useful starting material for the preparation of NPs surface decorated with this sialic acid.

journal_name

Biomaterials

journal_title

Biomaterials

authors

Bondioli L,Costantino L,Ballestrazzi A,Lucchesi D,Boraschi D,Pellati F,Benvenuti S,Tosi G,Vandelli MA

doi

10.1016/j.biomaterials.2010.01.049

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

3395-403

issue

12

eissn

0142-9612

issn

1878-5905

pii

S0142-9612(10)00065-7

journal_volume

31

pub_type

杂志文章

相关文献

BIOMATERIALS文献大全
  • Developing bioactive composite materials for tissue replacement.

    abstract：:A variety of bioactive composites have been investigated over the last two decades as substitute materials for diseased or damaged tissues in the human body. In this paper, the rationale and strategy of developing these composites are given. Major factors influencing the production and performance of bioactive composi...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/s0142-9612(03)00037-1

    authors： Wang M

    更新日期：2003-06-01 00:00:00

  • Surface modification of polycaprolactone with poly(methacrylic acid) and gelatin covalent immobilization for promoting its cytocompatibility.

    abstract：:Polycaprolactone (PCL) membrane was modified by grafting copolymerization of methacrylic acid (MAA) initiated under UV light. The covalent immobilization of gelatin on PCL-g-PMAA surface was consequently performed by using condensing agent, 1-ethyl-3-(3-dimethylamino propyl) carbodiimide hydrochloride. The occurrence ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00247-8

    authors： Zhu Y,Gao C,Shen J

    更新日期：2002-12-01 00:00:00

  • Cell adhesion on phase-separated surface of block copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) and poly(dimethylsiloxane).

    abstract：:We investigated the morphological effect of phase-separated block copolymer surfaces composed of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC) and poly(dimethylsiloxane) (PDMS) on protein adsorption and cell adhesion behavior. We observed three different types of phase-separated surface morphologies by T...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.06.031

    authors： Seo JH,Matsuno R,Takai M,Ishihara K

    更新日期：2009-10-01 00:00:00

  • Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA.

    abstract：:A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using these pol...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.06.021

    authors： Kainthan RK,Gnanamani M,Ganguli M,Ghosh T,Brooks DE,Maiti S,Kizhakkedathu JN

    更新日期：2006-11-01 00:00:00

  • Characterization of a hyaluronic acid-Arg-Gly-Asp peptide cell attachment matrix.

    abstract：:We have developed a method to modify cross-linked hyaluronic acid with peptides containing the Arg-Gly-Asp sequence. The material created by this process is a three-dimensional porous matrix capable of supporting integrin receptor-mediated cell attachment. Peptide density can be controlled by varying the reaction cond...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(96)85911-4

    authors： Glass JR,Dickerson KT,Stecker K,Polarek JW

    更新日期：1996-06-01 00:00:00

  • Quasi-living surface graft polymerization with phosphorylcholine group(s) at the terminal end.

    abstract：:A surface graft polymer with one or two phosphorylcholine (PC) polarheads at the terminus of the growing chain end was prepared by sequential reactions on a glass substrate. The dithiocarbamate group covalently bound to glass surfaces was derivatized with one or two PC groups and then irradiated with ultraviolet light...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(03)00349-1

    authors： Matsuda T,Kaneko M,Ge S

    更新日期：2003-11-01 00:00:00

  • FRET-enabled monitoring of the thermosensitive nanoscale assembly of polymeric micelles into macroscale hydrogel and sequential cognate micelles release.

    abstract：:Thermosensitive "micellar hydrogel" is prepared based on poly(ε-caprolactone-co- 1,4,8-trioxa[4.6]spiro-9-undecanone)-b-poly(ethylene glycol)- b-poly(ε-caprolactone- co-1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) triblock copolymer. Fluorescence resonance energy transfer (FRET) is adopted to explore its assembly (form...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.07.012

    authors： Huang P,Song H,Zhang Y,Liu J,Cheng Z,Liang XJ,Wang W,Kong D,Liu J

    更新日期：2017-11-01 00:00:00

  • Parameters influencing the stealthiness of colloidal drug delivery systems.

    abstract：:Over the last few decades, colloidal drug delivery systems (CDDS) such as nano-structures have been developed in order to improve the efficiency and the specificity of drug action. Their small size permits them to be injected intravenously in order to reach target tissues. However, it is known that they can be rapidly...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/j.biomaterials.2006.03.039

    authors： Vonarbourg A,Passirani C,Saulnier P,Benoit JP

    更新日期：2006-08-01 00:00:00

  • Role of material surfaces in regulating bone and cartilage cell response.

    abstract：:Tissue engineering in vitro and in vivo involves the interaction of cells with a material surface. The nature of the surface can directly influence cellular response, ultimately affecting the rate and quality of new tissue formation. Initial events at the surface include the orientated adsorption of molecules from the...

    journal_title：Biomaterials

    pub_type： 杂志文章,评审

    doi：10.1016/0142-9612(96)85758-9

    authors： Boyan BD,Hummert TW,Dean DD,Schwartz Z

    更新日期：1996-01-01 00:00:00

  • Tissue response to polyanionic collagen: elastin matrices implanted in rat calvaria.

    abstract：:The tissue response to polyanionic collagen matrices, prepared from bovine pericardium and implanted subperiosteally in rat calvaria, was studied. The materials were implanted in 72 male rats (Rattus norvegicus, albinus, Holtzman), randomly divided into four groups: GI-MBP hydrolyzed for 24 h; GII-MBP hydrolyzed for 3...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(02)00292-2

    authors： Rosa FP,Lia RC,de Souza KO,Goissis G,Marcantonio E Jr

    更新日期：2003-01-01 00:00:00

  • Dual carrier-cargo hydrophobization and charge ratio optimization improve the systemic circulation and safety of zwitterionic nano-polyplexes.

    abstract：:While polymeric nano-formulations for RNAi therapeutics hold great promise for molecularly-targeted, personalized medicine, they possess significant systemic delivery challenges including rapid clearance from circulation and the potential for carrier-associated toxicity due to cationic polymer or lipid components. Her...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.11.010

    authors： Jackson MA,Bedingfield SK,Yu F,Stokan ME,Miles RE,Curvino EJ,Hoogenboezem EN,Bonami RH,Patel SS,Kendall PL,Giorgio TD,Duvall CL

    更新日期：2019-02-01 00:00:00

  • Activation of complement C3 by different calcium phosphate powders.

    abstract：:The ability of different calcium phosphate to activate the complement system is studied by crossed immunoelectrophoresis demonstrating conversion of C3 to C3b. Complement consumption is determined by a haemolytic assay CH50. Hydroxyapatite powders after sintering induce a significant conversion of C3 and reduction of ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(83)90007-8

    authors： Klein CP,de Groot K,van Kamp G

    更新日期：1983-07-01 00:00:00

  • Development of next generation adeno-associated viral vectors capable of selective tropism and efficient gene delivery.

    abstract：:Virus-based nanoparticles have shown promise as vehicles for delivering therapeutic genes. However, the rational design of viral vectors that enable selective tropism towards particular types of cells and tissues remains challenging. Here, we explored structural-functional relationships of the adeno-associated virus 2...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.11.066

    authors： Zhang C,Yao T,Zheng Y,Li Z,Zhang Q,Zhang L,Zhou D

    更新日期：2016-02-01 00:00:00

  • In vitro leucocyte adhesion to modified polyurethane surfaces. I. Effect of ionizable functional groups.

    abstract：:To study the effect of ionizable functional groups on the adhesion of leucocytes to surfaces, both poly(ethyleneimine) and poly(acrylic acid) were immobilized on polyurethane films, resulting in the introduction of amine and carboxylic acid groups, respectively. This was confirmed by contact angle measurements and XPS...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(92)90114-4

    authors： Bruil A,Terlingen JG,Beugeling T,van Aken WG,Feijen J

    更新日期：1992-01-01 00:00:00

  • Antibody conjugated supported lipid bilayer for capturing and purification of viable tumor cells in blood for subsequent cell culture.

    abstract：:Interest in the identification and isolation of circulating tumor cells (CTCs) has been growing since the introduction of CTCs as an alternative to the tumor tissue biopsy, which can potentially be important indices for prognosis and cancer treatment. However, the contamination of non-specific binding of normal hemato...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.03.096

    authors： Wu JC,Tseng PY,Tsai WS,Liao MY,Lu SH,Frank CW,Chen JS,Wu HC,Chang YC

    更新日期：2013-07-01 00:00:00

  • A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.

    abstract：:Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt e...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2018.10.014

    authors： Loessner D,Rockstroh A,Shokoohmand A,Holzapfel BM,Wagner F,Baldwin J,Boxberg M,Schmalfeldt B,Lengyel E,Clements JA,Hutmacher DW

    更新日期：2019-01-01 00:00:00

  • A hematoporphyrin-based delivery system for drug resistance reversal and tumor ablation.

    abstract：:Nanotechnology-based drug delivery systems have been intensively investigated, while only a few of them can be used for clinic application. Hematoporphyrin (HP), a major molecule in erythrocyte, has been widely used in photodynamic therapy (PDT). In the present study, polyethylene glycol (PEG) modified hematoporphyrin...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2013.12.004

    authors： Ren Y,Wang R,Liu Y,Guo H,Zhou X,Yuan X,Liu C,Tian J,Yin H,Wang Y,Zhang N

    更新日期：2014-03-01 00:00:00

  • Microwave pumped high-efficient thermoacoustic tumor therapy with single wall carbon nanotubes.

    abstract：:The ultra-short pulse microwave could excite to the strong thermoacoustic (TA) shock wave and deeply penetrate in the biological tissues. Based on this, we developed a novel deep-seated tumor therapy modality with mitochondria-targeting single wall carbon nanotubes (SWNTs) as microwave absorbing agents, which act effi...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2015.10.028

    authors： Wen L,Ding W,Yang S,Xing D

    更新日期：2016-01-01 00:00:00

  • Nanoparticles of cationic amphiphilic cyclodextrins entangling anionic porphyrins as carrier-sensitizer system in photodynamic cancer therapy.

    abstract：:The photodynamic activity of a carrier-sensitizer system consisting of heterotopic colloidal nanoparticles (diameter 100-1000 nm) of a cationic amphiphilic cyclodextrin, heptakis(2-omega-amino-O-oligo(ethylene oxide)-6-hexylthio)-beta-CD (SC6CDNH2) encapsulating the anionic 5,10,15,20-tetrakis(4-sulfonatophenyl)-21H,2...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2006.03.035

    authors： Sortino S,Mazzaglia A,Monsù Scolaro L,Marino Merlo F,Valveri V,Sciortino MT

    更新日期：2006-08-01 00:00:00

  • Combined delivery of heme oxygenase-1 gene and fibroblast growth factor-2 protein for therapeutic angiogenesis.

    abstract：:Ectopic expression of heme oxygenase-1 (HO-1) in ischemic tissue protects the tissue from apoptosis and necrosis and promotes angiogenesis. However, apoptosis and necrosis will decrease HO-1 gene transfection efficacy. We hypothesized that fibroblast growth factor-2 (FGF2) would attenuate ischemic damage during the in...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2009.07.058

    authors： Bhang SH,Kim JH,Yang HS,La WG,Lee TJ,Sun AY,Kim GH,Lee M,Kim BS

    更新日期：2009-10-01 00:00:00

  • Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles.

    abstract：:Retinal degeneration impairs the vision of millions in all age groups worldwide. Increasing evidence suggests that the etiology of many retinal degenerative diseases is associated with impairment in biochemical reactions involved in the visual cycle, a metabolic pathway responsible for regeneration of the visual chrom...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.12.019

    authors： Puntel A,Maeda A,Golczak M,Gao SQ,Yu G,Palczewski K,Lu ZR

    更新日期：2015-03-01 00:00:00

  • Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk.

    abstract：:Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poo...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2020.120309

    authors： DiStefano TJ,Shmukler JO,Danias G,Di Pauli von Treuheim T,Hom WW,Goldberg DA,Laudier DM,Nasser PR,Hecht AC,Nicoll SB,Iatridis JC

    更新日期：2020-11-01 00:00:00

  • Effects of topography and composition of titanium surface oxides on osteoblast responses.

    abstract：:To investigate the roles of composition and characteristics of titanium surface oxides in cellular behaviour of osteoblasts, the surface oxides of titanium were modified in composition and topography by anodic oxidation in two kinds of electrolytes, (a) 0.2 M H(3)PO(4), and (b) 0.03 M calcium glycerophosphate (Ca-GP) ...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2003.11.011

    authors： Zhu X,Chen J,Scheideler L,Reichl R,Geis-Gerstorfer J

    更新日期：2004-08-01 00:00:00

  • Carbon nanotube-based substrates for modulation of human pluripotent stem cell fate.

    abstract：:We investigated the biological response of human pluripotent stem cells (hPSCs) cultured on a carbon nanotube (CNT) array-based substrate with the long term goal to direct hPSC germ layer specification for a wide variety of tissue engineering applications. CNT arrays were fabricated using a chemical vapor deposition s...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2014.03.011

    authors： Pryzhkova MV,Aria I,Cheng Q,Harris GM,Zan X,Gharib M,Jabbarzadeh E

    更新日期：2014-06-01 00:00:00

  • Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents.

    abstract：:The objective of this study was to develop radiopaque iodinated emulsions for use as CT blood pool contrast agents. Three hydrophobic iodinated oils were synthesized based on the 2,3,5-triiodobenzoate moiety and formulated into emulsions using either phospholipids or amphiphilic polymers, i.e. Pluronic F68 and poly(bu...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.04.056

    authors： de Vries A,Custers E,Lub J,van den Bosch S,Nicolay K,Grüll H

    更新日期：2010-09-01 00:00:00

  • The role of stiffness of gelatin-hydroxyphenylpropionic acid hydrogels formed by enzyme-mediated crosslinking on the differentiation of human mesenchymal stem cell.

    abstract：:We report the stimulation of neurogenesis and myogenesis of human mesenchymal stem cells (hMSCs) on the surfaces of biodegradable hydrogels with different stiffness. The hydrogels were composed of gelatin-hydroxyphenylpropionic acid (Gtn-HPA) conjugate were formed using the oxidative coupling of phenol moieties cataly...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2010.07.075

    authors： Wang LS,Boulaire J,Chan PP,Chung JE,Kurisawa M

    更新日期：2010-11-01 00:00:00

  • Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis.

    abstract：:CD47, a "don't eat me" signal, is over-expressed on the surface of most tumors that interacts with signal regulatory protein α (SIRPα) on phagocytic cells. By engaging SIRPα, CD47 limits the ability of macrophages to engulf tumor cells, which acts as a major phagocytic barrier. In this study, we developed an exosome-b...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2017.01.004

    authors： Koh E,Lee EJ,Nam GH,Hong Y,Cho E,Yang Y,Kim IS

    更新日期：2017-03-01 00:00:00

  • Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma.

    abstract：:Nitric oxide is a cell signaling molecule that can be a potent inducer of cell death in cancers at elevated concentrations. However, NO is also toxic to normal tissues and chronic exposure at low levels can induce tumor growth. We have designed a polymeric carrier system to deliver nitric oxide locoregionally to tumor...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/j.biomaterials.2012.01.026

    authors： Duan S,Cai S,Yang Q,Forrest ML

    更新日期：2012-04-01 00:00:00

  • Corrosion behavior of titanium nitride coated Ni-Ti shape memory surgical alloy.

    abstract：:Nickel-titanium (NiTi, nitinol) shape memory alloy was nitrided using an original powder immersion reaction assisted coating (PIRAC) method in order to modify its surface properties. PIRAC nitriding method is based on annealing the samples in the atmosphere of highly reactive nitrogen supplied by decomposition of unst...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/s0142-9612(00)00368-9

    authors： Starosvetsky D,Gotman I

    更新日期：2001-07-01 00:00:00

  • Long-term stability in vivo of a thromboresistant heparinized surface.

    abstract：:A surface with covalently bonded heparin was tested in an in vivo model. Heparinized and non-heparinized tubings were inserted in the pig aorta. They were left in place for up to 16 wk. After removal they were analysed for their capacity to take up and inhibit thrombin. A comparison was also made with tubings that had...

    journal_title：Biomaterials

    pub_type： 杂志文章

    doi：10.1016/0142-9612(87)90088-3

    authors： Arnander C,Bagger-Sjöbäck D,Frebelius S,Larsson R,Swedenborg J

    更新日期：1987-11-01 00:00:00