Abstract：
:The tissue response to polyanionic collagen matrices, prepared from bovine pericardium and implanted subperiosteally in rat calvaria, was studied. The materials were implanted in 72 male rats (Rattus norvegicus, albinus, Holtzman), randomly divided into four groups: GI-MBP hydrolyzed for 24 h; GII-MBP hydrolyzed for 36 h; GIII-MBP hydrolyzed for 48 h; GIV-native MBP. The materials were explanted after 15, 30 and 60 days and analyzed by routine histological procedures. Except for group IV (native bovine pericardium), polyanionic collagen from groups GI, GII and GIII showed low inflammatory reaction associated with bone formation, partially or completely integrated to the cranial bone; group GIV was characterized by an intense inflammatory reaction with occasional dystrophic mineralization and with occasional bone formation at 60 days when there was a decrease in the inflammatory reaction. Thus, the MBP from groups I, II and III were biologically compatible, enhancing bone formation with a slight delay at 60 days in GII.
journal_name
Biomaterialsjournal_title
Biomaterialsauthors
Rosa FP,Lia RC,de Souza KO,Goissis G,Marcantonio E Jrdoi
10.1016/s0142-9612(02)00292-2keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
207-12issue
2eissn
0142-9612issn
1878-5905pii
S0142961202002922journal_volume
24pub_type
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